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Transient Receptor Potential Cation Channel, Subfamily V, Member 4 Proteins (TRPV4)

TRPV4 encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. Additionally we are shipping TRPV4 Antibodies (98) and TRPV4 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRPV4 59341 Q9HBA0
TRPV4 63873 Q9EPK8
Rat TRPV4 TRPV4 66026 Q9ERZ8
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Top TRPV4 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details

TRPV4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
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More Proteins for Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) Interaction Partners

Zebrafish Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) interaction partners

  1. TRPP2 and TRPV4 are mechanosensitive channels in the endocardium.Oscillatory flow modulates mechanosensitive klf2a expression through trpv4 and trpp2 during heart valve development.

  2. TRPP2 utilizes TRPV4 to form a mechano- and thermosensitive molecular sensor in the cilium.

  3. Age-dependence of heat-activated seizure susceptibility mimicks the mRNA expression of TRPV4 and glutamate (show GRIN2A Proteins) receptors.

  4. TRPV4 present in all sensory organs of adult zebrafish.

  5. Study reports cloning of a zebrafish trpv4 cDNA and assaying its expression during embryogenesis; trpv4 is expressed as maternal mRNA in 4-cell embryos and later zygotic expression is first observed in the forming notochord at the one somite stage.

  6. OS-9 (show OS9 Proteins) regulates the secretory transport of TRPV4 and appears to protect TRPV4 subunits from the precocious ubiquitination and ER-associated degradation.

Human Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) interaction partners

  1. Role of endothelial TRPV4 channels in vascular actions of the endocannabinoid, 2-arachidonoylglycerol

  2. the activation of myenteric TRPV4 and the subsequent production of NO by these neurons have the potential to become an important target for the pharmacological treatment of GI disorders with predominant hypermotility symptoms.

  3. these data strongly suggest endogenous TRPV4 channels as a mechanosensor, mediating cyclic stretch-induced realignment of hESC-CMs (show Cd2ap Proteins).

  4. Identify TRPV4 as novel regulator of neutrophil activation and suggest contributions of both parenchymal and neutrophilic TRPV4 in the pathophysiology of acute lung injury.

  5. TRPV4 regulates dynamics of trailing adhesions.

  6. A mutation in TRPV4 results in altered chondrocyte calcium signaling in severe metatropic dysplasia.

  7. Calcium sensitive TRPV4 translocation is associated with the regulation of endothelial response to mechanical stimulation.

  8. The inflammatory cytokine TNF-a (show TNF Proteins) can modulate the activity of the mechanosensitive ion channels TRPA1 (show TRPA1 Proteins) and TRPV4 in odontoblasts via the p38 MAPK (show MAPK14 Proteins) pathway but has differential effects on their expression.

  9. Interaction between the linker, pre-S1, and TRP (show TBPL1 Proteins) domains determines folding, assembly, and trafficking of TRPV1 (show TRPV1 Proteins) and TRPV4 channels.

  10. Neurography revealed a late-onset sensory neuropathy in the father, which was so far not described in TRPV4 neuropathies.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) interaction partners

  1. Aquaporin-mediated fast swelling kinetics play a key role in cell volume regulation (together with TRPV4) and calcium signaling in astrocytes

  2. In subcutaneous adipose tissue, a high fat diet elevated TRPV4, exercise, and exercise plus rutin completely reduced TRPV4 to normal level.

  3. TRPV4 regulates neuronal excitability and social behavior through its activation at the physiological temperature in vivo.

  4. TRPV4-mediated nociceptive information from the peripheral tissue excluding the spinal pathway might be involved the formalin behavioral response during phase I. Only TRPV1 (show TRPV1 Proteins) might regulate the formalin behavioral response in peripheral neuron.

  5. TRPV4 channels regulate tumor angiogenesis by selectively inhibiting tumor endothelial cell proliferation.

  6. Identify TRPV4 as novel regulator of neutrophil activation and suggest contributions of both parenchymal and neutrophilic TRPV4 in the pathophysiology of acute lung injury.

  7. Our findings demonstrate TRPV4 channels to be critical regulators of tumor angiogenesis and represent a novel target for anti-angiogenic and vascular normalization therapies.

  8. GPCR (show GPBAR1 Proteins)-TRPV4 channel interactions comprise a key signalling pathway for the endothelium-dependent regulation of vascular tone.

  9. The findings suggest that signaling through TRPV4, triggered by changes in extracellular matrix stiffness, cooperates with LPS (show TLR4 Proteins)-induced signals to mediate macrophage phagocytic function and lung injury resolution.

  10. Data suggest that blockage of transient receptor potential (TRP) channels TRPA1 (show TRPA1 Proteins), TRPV4 and possibly TRPM8 (show TRPM8 Proteins) may represent a therapeutic option for patients with colonic discomfort and pain.

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) interaction partners

  1. Data indicate a physiologic function of transient receptor potential vanilloid 4 (TRPV4) in the regulation of blood-cerebrospinal fluid barrier (BCSFB) permeability.

  2. Hyposmotic shock-induced TRPV4 channel activation regulates hemichannel-mediated ATP release and Na-K-ATPase (show ATP1A1 Proteins) activity in lens epithelium.

  3. The large amounts of transported calcium and the short signaling ways suggest a potentially important role of TRPV4 in many physiological processes.

  4. TRPV4 is present in articular chondrocytes in swine, and chondrocyte response to hypo-osmotic stress is mediated by this channel, which involves both an extracellular Ca(2 (show CA2 Proteins)+) and intracellular Ca(2 (show CA2 Proteins)+) release.

Cow (Bovine) Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) interaction partners

  1. TRPV4 channels activity in bovine articular chondrocytes are regulated by obesity-associated mediators.

  2. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling.

TRPV4 Protein Profile

Protein Summary

This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TRPV4

  • transient receptor potential cation channel, subfamily V, member 4 (trpv4)
  • transient receptor potential cation channel, subfamily V, member 4 (TRPV4)
  • transient receptor potential cation channel, subfamily V, member 4 (LOC100220808)
  • transient receptor potential cation channel, subfamily V, member 4 (Trpv4)
  • 0610033B08Rik protein
  • CMT2C protein
  • HMSN2C protein
  • Otrpc4 protein
  • SMAL protein
  • SPSMA protein
  • SSQTL1 protein
  • Trp12 protein
  • VR-OAC protein
  • VRL-2 protein
  • VRL2 protein
  • Vroac protein
  • wu:fp52e02 protein

Protein level used designations for TRPV4

transient receptor potential cation channel subfamily V member 4 , transient receptor potential cation channel, subfamily V, member 4 , transient receptor potential cation channel subfamily V member 4-like , OSM9-like transient receptor potential channel 4 , osm-9-like TRP channel 4 , osmosensitive transient receptor potential channel 4 , transient receptor potential protein 12 , vanilloid receptor-like channel 2 , vanilloid receptor-related osmotically activated channel , vanilloid receptor-like protein 2 , vanilloid receptor-related osmotically-activated channel , VR-OAC , transient receptor potential cation channel, subfamily 5, member 4 , vanilloid receptor-related osmotically activated channel (Vroac) , vanilloid receptor-related osmotically activated channel protein

GENE ID SPECIES
557850 Danio rerio
709605 Macaca mulatta
100458589 Pongo abelii
100472561 Ailuropoda melanoleuca
100539676 Meleagris gallopavo
100590720 Nomascus leucogenys
100220808 Taeniopygia guttata
59341 Homo sapiens
63873 Mus musculus
66026 Rattus norvegicus
395427 Gallus gallus
486308 Canis lupus familiaris
100126845 Sus scrofa
540259 Bos taurus
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