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TRPV5 is a member of the transient receptor family and the TrpV subfamily. Additionally we are shipping TRPV5 Antibodies (73) and TRPV5 Kits (1) and many more products for this protein.
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TRPV5 and TRPV6 (show TRPV6 Proteins) were upregulated with time and passage in culture suggesting that a shift in the phenotype of the cells in monolayer culture alters the expression of these channels.
In Equus caballus, TRPV5 mRNA is highly expressed in the kidney but scarce in the duodenum and heart. Protein expression followed a similar pattern.
beta-gal (show GLB1 Proteins) is present in the pro-urine from where it is thought to stimulate TRPV5 activity.
A novel primary cell model with TRPV5-dependent Ca(2 (show CA2 Proteins)+) transport characteristics was successfully established.
Phosphorylation of beta1-AR by PKA stimulates active Ca(2 (show CA2 Proteins)+)influx through TRPV5.
The expression of TRPV5 channel is regulated by estrogen via estrogen receptor (show ESR1 Proteins) in osteoblasts.
Uromodulin (show UMOD Proteins) upregulates TRPV5 by decreasing caveolin-1 (show CAV1 Proteins) dependent endocytosis of TRPV5.
In colitis in mice, tumor necrosis factor (show TNF Proteins) and interferon-gamma (show IFNG Proteins) reduced expression of Klotho (show KL Proteins), which otherwise would protect TRPV5 from hypersialylation and cytokine-induced TRPV5 endocytosis, UBR4-dependent ubiquitination, degradation, and Ca(2 (show CA2 Proteins)+) wasting.
The TRPV5 S682P mutant is a functionally significant factor in autosomal dominant hypercalciuria.
promoter driven Cre recombinase (show RAG1 Proteins) expression will be useful for inducing DCT2 and CNT specific gene silencing of various channels, pumps, carriers, and receptors
Calcitonin (show CALCA Proteins) augments the renal reabsorptive capacity for Ca(2 (show CA2 Proteins)+). This increase is likely to occur independently of TRPV5.
TrpV5 mediates basal renal calcium absorption in null mutant mice lacking calcium channel beta3 subunits (CaVbeta3) and multimeric calcium channel entry via distal convoluted renal tubules.
The alterations may lead to misfolding of TRPV5, reduction in translocation of the channel to the plasma membrane and/or impaired Ca(2 (show CA2 Proteins)+) transport function of the channel, and ultimately disrupt TRPV5-mediated Ca(2 (show CA2 Proteins)+) reabsorption.
These findings indicate that the A563T variation induces structural, dynamical, and electrostatic changes in the TRPV5 pore, providing structural insight into the functional alterations associated with the A563T variation.
Data found that a TRPV5 polymorphism (rs4236480) was observed to be associated with stone multiplicity of calcium nephrolithiasis, as the risk of stone multiplicity was higher in patients with the TT+CT genotype than in patients with the CC genotype
High TRPV5 expression is aassociated with adenoma of parathyroid glands.
Klotho (show KL Proteins) up-regulates TRPV5 from both the inside and outside of cells.
Decreased expression of TRPV5 is associated with non-small cell lung cancer.
Upregulating the expression of TRPV5 can be utilized to manipulate transmembrane Ca2 (show CA2 Proteins)+ transport, and may serve as an alternative for the treatment of Ca2 (show CA2 Proteins)+ balance-related diseases.
These results suggest that TRPV5 and TRPV6 (show TRPV6 Proteins) are crucial gates controlling cadmium and zinc levels in the human body.
these data showed that TRPV5/TRPV6 (show TRPV6 Proteins) in human lymphocytes are functionally active, and their activity is associated with proliferative status of blood cells.
Data indicate that transient receptor potential vanilloid type 5 (TRPV5) plasma membrane retention is regulated via lipid rafts.
mutation of a pore helix residue glutamate-535 to glutamine (E535Q) enhances the sensitivity of the channel to inhibition by extracellular protons
Results suggest that intracellular acidification directly inhibits TRPV5 by causing a conformational change(s) leading to a decrease of open probability of TRPV5 as well as of the single-channel conductance.
Activation of the CaR stimulates TRPV5-mediated Ca(2+) influx via a PMA-insensitive PKC isoform pathway.
This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.
transient receptor potential cation channel, subfamily V, member 5
, epithelial calcium channel 1
, transient receptor potential cation channel subfamily V member 5
, calcium transport protein 2
, osm-9-like TRP channel 3
, calcium transporter 2