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anti-Translin (TSN) Antibodies

TSN encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Additionally we are shipping Translin Proteins (13) and Translin Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TSN 7247 Q15631
TSN 22099 Q62348
TSN 60381  
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Top anti-Translin Antibodies at antibodies-online.com

Showing 10 out of 48 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB TSN Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of TSN Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. TSN Antibody (Center) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the TSN antibody detected the TSN protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells, using TSN Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using TSN Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB Immunofluorescence of Translin in human lung tissue with Translin antibody at 20 µg/ml.  Immunohistochemistry of Translin in Human lung tissue with Translin antibody at 5 µg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB TSN Antibody (Center)  western blot analysis in HL-60,Jurkat,K562 cell line mouse spleen tissue lysates (35ug/lane).This demonstrates the TSN antibody detected the TSN protein (arrow). Fluorescent confocal image of Hela cell stained with TSN Antibody(Center).Hela cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with TSN primary antibody (1:25, 1 h at 37℃). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37℃).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃). Nuclei were counterstained with DAPI (blue) (10 µg/ml, 10 min).TSN immunoreactivity is localized to Nucleus and Cytoplasm significantly. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-TSN AntibodyTitration: 1.0 µg/mL  Positive Control: 293T Whole Cell  There is BioGPS gene expression data showing that TSN is expressed in HEK293T 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of Translin staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of Translin expression in MCF7 (A), HeLa (B), HepG2 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p), WB Immunohistochemistry analysis of Translin Antibody in paraffin-embedded human brain tissue. Western blot analysis of Translin Antibody  in extracts from Jurkat cells. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-Fixed, Paraffin-Embedded Human Testis stained with TSN Western blot analysis of extracts from Jurkat cells using TSN Antibody . The lane on the right is treated with the synthesized peptide. 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details

TSN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
,

, , , , ,
Mouse (Murine)


Rat (Rattus)


Top referenced anti-Translin Antibodies

  1. Human Polyclonal TSN Primary Antibody for EIA, IHC (p) - ABIN955319 : Chiaruttini, Vicario, Li, Baj, Braiuca, Wu, Lee, Gardossi, Baraban, Tongiorgi: Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation. in Proceedings of the National Academy of Sciences of the United States of America 2009 (PubMed)
    Show all 3 references for ABIN955319

  2. Human Polyclonal TSN Primary Antibody for EIA, IF - ABIN783484 : Aoki, Suzuki, Sugano, Tasaka, Nakahara, Kuge, Omori, Kasai: A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations. in Nature genetics 1995 (PubMed)
    Show all 2 references for ABIN783484

  3. Human Polyclonal TSN Primary Antibody for IHC, ELISA - ABIN1533915 : Aoki, Inazawa, Takahashi, Nakahara, Kasai: Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein. in Genomics 1997 (PubMed)
    Show all 2 references for ABIN1533915

More Antibodies against Translin Interaction Partners

Fruit Fly (Drosophila melanogaster) Translin (TSN) interaction partners

  1. These studies establish that Trax (show TSNAX Antibodies) adopts the translin fold, possesses catalytic centers essential for C3PO's endoRNase activity and interacts extensively with translin to form an octameric assembly.

  2. Drosophila translin exhibits a stable dimeric state that assembles into a suboctameric (tetramer/hexamer) form and fails (show AK3 Antibodies) to bind ssDNA and RNA targets

  3. A translin null mutant was generated and a trax (show TSNAX Antibodies) nonsense mutation was isolated. Translin is essential for stabilizing its interaction with trax (show TSNAX Antibodies).

  4. Drosophila translin may have roles in neuronal development and behavior analogous to that of mouse translin.

  5. Results suggest that the oligomeric status of translin critically influences the DNA binding properties of translin proteins.

  6. an RNAi regulator that we term C3PO (component 3 promoter of RISC (show SCPEP1 Antibodies)), a complex of Translin and Trax (show TSNAX Antibodies) was purified; C3PO is a Mg2 (show MCOLN1 Antibodies)+-dependent endoribonuclease that promotes RISC (show SCPEP1 Antibodies) activation by removing siRNA passenger strand cleavage products

Human Translin (TSN) interaction partners

  1. These findings indicate that miRNA depletion in dicer (show DICER1 Antibodies) deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX.

  2. this study argues against a mechanism by which translin octamers may "dissociate and reassemble" upon RNA binding and report a novel "open"-barrel structure of human translin revealing a feasible DNA/RNA entryway into the cavity.

  3. The selectivity of PLCbeta toward certain genes lies in the rate at which the RNA is hydrolyzed by C3PO.

  4. The data demonstrates that the configuration of translin and translin-RNA complexes in solution is a dimer of tetramers, which undergoes conformational transitions.

  5. Translin B3 motif, corresponding to TRAX (show TSNAX Antibodies) B3 residues, contributes towards its DNA binding activity.

  6. C3PO endonuclease is an asymmetric octamer barrel consisting of six translin and two TRAX (show TSNAX Antibodies) subunits which activates RISC (show SCPEP1 Antibodies) by degrading the Ago2 (show EIF2C2 Antibodies)-nicked passenger strand of siRNA.

  7. Sedimentation equilibrium studies using fluorescein-labeled single-stranded DNA support a model in which translin forms an annular structure of eight subunits, an oblate ellipsoid that binds single-stranded DNA at chromosomal breakpoints.

  8. study of reactivity of two -SH groups and stidu of proximity of Cys (show DNAJC5 Antibodies)-225 residues

  9. At high enough concentrations, translin binds duplex DNA by selectively loading from the free ends, which apparently results in clamping of strands at the duplex ends.

  10. The core protein of HCV can interact with translin protein. This can partly explain the molecular mechanism for hepatocellular carcinoma and lymphoma caused by HCV

Mouse (Murine) Translin (TSN) interaction partners

  1. These findings indicate that miRNA depletion in dicer (show DICER1 Antibodies) deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX.

  2. These in vivo and in vitro findings of this study indicated that dendritic trafficking of BDNF (show BDNF Antibodies) mRNA can be mediated by both translin-dependent and -independent mechanisms.

  3. trax (show TSNAX Antibodies) acts to regulate translin's RNA and DNA binding affinities as part of a cellular RNA trafficking mechanism.

  4. TB-RBP is involved in the posttranscriptional regulation of Gapds (show GAPDHS Antibodies) gene expression during spermiogenesis.

  5. TB-RBP-null male mice were fertile and sired offspring but had abnormal seminiferous tubules and reduced sperm counts. Null female mice were subfertile, had reduced litter sizes; analysis of brain RNA from null mice revealed an altered gene expression

  6. TB-RBP-mouse ribonucleoprotein complex transports a group of specific CREM (show CREM Antibodies)-regulated mRNAs in mammalian male postmeiotic germ cells.

  7. TB-RBP post-transcriptionally stabilizes TRAX (show TSNAX Antibodies) and both proteins are needed for normal cell proliferation

  8. subcellular locations of TB-RBP and TRAX (show TSNAX Antibodies) in male germ cells are modulated by the relative ratios of TRAX (show TSNAX Antibodies) and TB-RBP

  9. During a search for RNA-induced silencing complex (RISC (show SCPEP1 Antibodies)) proteins that directly interact with small interference RNA, the authors identify TB-RBP in NIH3T3 cell lysate and show that it possesses both single- and double-stranded RNase activities.

  10. These studies have, for the first time, identified both mRNAs and a non-coding RNA as TSN targets expressed during meiosis

Translin (TSN) Antigen Profile

Protein Summary

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with anti-Translin (TSN) Antibodies

  • translin (tsn) antibody
  • translin (TSN) antibody
  • translin (trsn) antibody
  • Translin (Mmah_0686) antibody
  • translin (Tagg_1053) antibody
  • Translin (Igag_0962) antibody
  • translin (Mfer_0716) antibody
  • translin (Desmu_0251) antibody
  • translin (Arcve_1059) antibody
  • translin (Mzhil_0248) antibody
  • translin (Tsn) antibody
  • 2610034C24Rik antibody
  • AU040286 antibody
  • BCLF-1 antibody
  • C3PO antibody
  • CG11761 antibody
  • Dmel\\CG11761 antibody
  • MGC52533 antibody
  • RCHF1 antibody
  • REHF-1 antibody
  • TB-RBP antibody
  • TBRBP antibody
  • TRSLN antibody
  • TSN antibody

Protein level used designations for anti-Translin (TSN) Antibodies

translin , CG11761-PA , testis-brain RNA binding protein , trsn-PA , Translin , component 3 of promoter of RISC , recombination hotspot associated factor , recombination hotspot-binding protein , testis brain-RNA binding protein , testis/brain RNA-binding protein , testis/brain-RNA-binding protein , translin protein

GENE ID SPECIES
380118 Xenopus laevis
459586 Pan troglodytes
36110 Drosophila melanogaster
8982842 Methanohalophilus mahii DSM 5219
9166084 Thermosphaera aggregans DSM 11486
9716278 Ignisphaera aggregans DSM 17230
9962446 Methanothermus fervidus DSM 2088
10152942 Desulfurococcus mucosus DSM 2162
10394172 Archaeoglobus veneficus SNP6
10821850 Methanosalsum zhilinae DSM 4017
7247 Homo sapiens
22099 Mus musculus
60381 Rattus norvegicus
509943 Bos taurus
395955 Gallus gallus
100689410 Cricetulus griseus
100189807 Pongo abelii
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