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Translin Proteins (TSN)

TSN encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Additionally we are shipping Translin Antibodies (48) and Translin Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TSN 7247 Q15631
TSN 22099 Q62348
Rat TSN TSN 60381  
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Top Translin Proteins at antibodies-online.com

Showing 9 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated Figure annotation denotes ug of protein loaded and % gel used. 100 μg Log in to see 7 to 9 Days
$467.86
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,572.17
Details
Yeast Cricetulus griseus His tag   1 mg Log in to see 56 to 66 Days
$2,572.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,572.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 μg Log in to see 6 to 11 Days
$142.86
Details
Human Un-conjugated   5 μg Log in to see 6 Days
$168.54
Details

TSN Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Translin (TSN) Interaction Partners

Fruit Fly (Drosophila melanogaster) Translin (TSN) interaction partners

  1. These studies establish that Trax (show TSNAX Proteins) adopts the translin fold, possesses catalytic centers essential for C3PO's endoRNase activity and interacts extensively with translin to form an octameric assembly.

  2. Drosophila translin exhibits a stable dimeric state that assembles into a suboctameric (tetramer/hexamer) form and fails (show AK3 Proteins) to bind ssDNA and RNA targets

  3. A translin null mutant was generated and a trax (show TSNAX Proteins) nonsense mutation was isolated. Translin is essential for stabilizing its interaction with trax (show TSNAX Proteins).

  4. Drosophila translin may have roles in neuronal development and behavior analogous to that of mouse translin.

  5. Results suggest that the oligomeric status of translin critically influences the DNA binding properties of translin proteins.

  6. an RNAi regulator that we term C3PO (component 3 promoter of RISC), a complex of Translin and Trax was purified; C3PO is a Mg2+-dependent endoribonuclease that promotes RISC activation by removing siRNA passenger strand cleavage products

Human Translin (TSN) interaction partners

  1. These findings indicate that miRNA depletion in dicer (show DICER1 Proteins) deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX.

  2. this study argues against a mechanism by which translin octamers may "dissociate and reassemble" upon RNA binding and report a novel "open"-barrel structure of human translin revealing a feasible DNA/RNA entryway into the cavity.

  3. The selectivity of PLCbeta toward certain genes lies in the rate at which the RNA is hydrolyzed by C3PO.

  4. The data demonstrates that the configuration of translin and translin-RNA complexes in solution is a dimer of tetramers, which undergoes conformational transitions.

  5. Translin B3 motif, corresponding to TRAX (show TSNAX Proteins) B3 residues, contributes towards its DNA binding activity.

  6. C3PO endonuclease is an asymmetric octamer barrel consisting of six translin and two TRAX (show TSNAX Proteins) subunits which activates RISC by degrading the Ago2 (show EIF2C2 Proteins)-nicked passenger strand of siRNA.

  7. Sedimentation equilibrium studies using fluorescein-labeled single-stranded DNA support a model in which translin forms an annular structure of eight subunits, an oblate ellipsoid that binds single-stranded DNA at chromosomal breakpoints.

  8. study of reactivity of two -SH groups and stidu of proximity of Cys (show DNAJC5 Proteins)-225 residues

  9. At high enough concentrations, translin binds duplex DNA by selectively loading from the free ends, which apparently results in clamping of strands at the duplex ends.

  10. The core protein of HCV can interact with translin protein. This can partly explain the molecular mechanism for hepatocellular carcinoma and lymphoma caused by HCV

Mouse (Murine) Translin (TSN) interaction partners

  1. These findings indicate that miRNA depletion in dicer (show DICER1 Proteins) deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX.

  2. These in vivo and in vitro findings of this study indicated that dendritic trafficking of BDNF (show BDNF Proteins) mRNA can be mediated by both translin-dependent and -independent mechanisms.

  3. trax (show TSNAX Proteins) acts to regulate translin's RNA and DNA binding affinities as part of a cellular RNA trafficking mechanism.

  4. TB-RBP is involved in the posttranscriptional regulation of Gapds (show GAPDHS Proteins) gene expression during spermiogenesis.

  5. TB-RBP-null male mice were fertile and sired offspring but had abnormal seminiferous tubules and reduced sperm counts. Null female mice were subfertile, had reduced litter sizes; analysis of brain RNA from null mice revealed an altered gene expression

  6. TB-RBP-mouse ribonucleoprotein complex transports a group of specific CREM (show CREM Proteins)-regulated mRNAs in mammalian male postmeiotic germ cells.

  7. TB-RBP post-transcriptionally stabilizes TRAX (show TSNAX Proteins) and both proteins are needed for normal cell proliferation

  8. subcellular locations of TB-RBP and TRAX (show TSNAX Proteins) in male germ cells are modulated by the relative ratios of TRAX (show TSNAX Proteins) and TB-RBP

  9. During a search for RNA-induced silencing complex (RISC) proteins that directly interact with small interference RNA, the authors identify TB-RBP in NIH3T3 cell lysate and show that it possesses both single- and double-stranded RNase activities.

  10. These studies have, for the first time, identified both mRNAs and a non-coding RNA as TSN targets expressed during meiosis

Translin (TSN) Protein Profile

Protein Summary

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Translin Proteins (TSN)

  • translin (tsn)
  • translin (TSN)
  • translin (trsn)
  • Translin (Mmah_0686)
  • translin (Tagg_1053)
  • Translin (Igag_0962)
  • translin (Mfer_0716)
  • translin (Desmu_0251)
  • translin (Arcve_1059)
  • translin (Mzhil_0248)
  • translin (Tsn)
  • 2610034C24Rik protein
  • AU040286 protein
  • BCLF-1 protein
  • C3PO protein
  • CG11761 protein
  • Dmel\\CG11761 protein
  • MGC52533 protein
  • RCHF1 protein
  • REHF-1 protein
  • TB-RBP protein
  • TBRBP protein
  • TRSLN protein
  • TSN protein

Protein level used designations for Translin Proteins (TSN)

translin , CG11761-PA , testis-brain RNA binding protein , trsn-PA , Translin , component 3 of promoter of RISC , recombination hotspot associated factor , recombination hotspot-binding protein , testis brain-RNA binding protein , testis/brain RNA-binding protein , testis/brain-RNA-binding protein , translin protein

GENE ID SPECIES
380118 Xenopus laevis
459586 Pan troglodytes
36110 Drosophila melanogaster
8982842 Methanohalophilus mahii DSM 5219
9166084 Thermosphaera aggregans DSM 11486
9716278 Ignisphaera aggregans DSM 17230
9962446 Methanothermus fervidus DSM 2088
10152942 Desulfurococcus mucosus DSM 2162
10394172 Archaeoglobus veneficus SNP6
10821850 Methanosalsum zhilinae DSM 4017
7247 Homo sapiens
22099 Mus musculus
60381 Rattus norvegicus
509943 Bos taurus
395955 Gallus gallus
100689410 Cricetulus griseus
100189807 Pongo abelii
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