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The protein encoded by TIMM23 is part of a complex located in the inner mitochondrial membrane that mediates the transport of transit peptide-containing proteins across the membrane. Additionally we are shipping Translocase of Inner Mitochondrial Membrane 23 Homolog (Yeast) Antibodies (31) and Translocase of Inner Mitochondrial Membrane 23 Homolog (Yeast) Kits (11) and many more products for this protein.
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Heterozygote Tim23 knockout mice exhibit a reduced lifespan and defective mitochondrial import.
The interaction of presequence peptides with Tim23 intermembrane space domain is weakened in presence of Ca2 (show CA2 Proteins)+ ion, which implicates that Ca2 (show CA2 Proteins)+ ion may play an important role in the protein import by TIM23 complex.
Modulating the sorting of nuclear-encoded proteins into mitochondria, mediated by the TIM23 complex, proves therapeutic in both yeast and patient-derived cells exhibiting ATP synthase deficiency.
Three distinct Tim23 complexes, namely, B1, B2, and A, are involved in the maintenance of normal mitochondrial function.
GST pull-down experiments and tryptophan fluorescence indicated that there is no interaction between Tim23IMS and Tim50IMS
MCJ functions as J co-chaperone of the human TIM23 pre-protein translocase.
Study establishes an unexpected molecular link between the TIM23 transport machinery and assembly of respiratory-chain complexes that regulate mitochondrial protein (show COX6B2 Proteins) synthesis in response to their assembly state.
The non-bound hydrophilic domain of the human Tim23 is in a molten globule configuration with marginal stability, existing as a dimer.
The protein encoded by this gene is part of a complex located in the inner mitochondrial membrane that mediates the transport of transit peptide-containing proteins across the membrane. Multiple transcript variants, one protein-coding and others not protein-coding, have been found for this gene.
mitochondrial import inner membrane translocase subunit Tim23
, translocase of inner mitochondrial membrane 23 homolog
, putative mitochondrial import inner membrane translocase subunit Tim23B