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Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane (By similarity). Additionally we are shipping Translocase of Inner Mitochondrial Membrane 50 Homolog (S. Cerevisiae) Antibodies (43) and Translocase of Inner Mitochondrial Membrane 50 Homolog (S. Cerevisiae) Kits (11) and many more products for this protein.
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A knockout mutant of the Arabidopsis TIM50 gene showed a reduction in hypocotyl length. TIM50 knockout caused enlargement and deformation of the mitochondrial structure and a reduction in intracellular ATP levels.
TIM50 has a role in regulating cell proliferation and apoptosis through decreasing mitochondrial membrane potential in breast cancer cell
the interaction of divalent metal ions with the intermembrane space domain of Tim50 (Tim50(IMS)) and the interaction of presequence peptides with Tim50(IMS) in presence of Ca(2 (show CA2 Proteins)+) ion was investigated.
The far-UV CD spectra of Tim50(IMS) in native and denatured states revealed that the protein has a significantly folded secondary structure consisted of alpha-helixes and beta-sheets.
Tim50 regulates 3betaHSD2 expression and activity, representing a new role for translocases in steroidogenesis.
TIM50, was upregulated in a non-small cell lung carcinoma cell line (H1299) that expressed the p53 (show TP53 Proteins) mutants R175H and R273H compared to cells lacking p53 (show TP53 Proteins).
Tim50 is important for both mitochondrial function and early neuronal development
Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with coilin (show COIL Proteins), snRNPs, and SMN (show STMN1 Proteins)
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane (By similarity).
potential mitochondrial presequence translocase guide protein
, mitochondrial import inner membrane translocase subunit TIM50
, translocase of inner mitochondrial membrane 50 homolog
, Tim50-like protein
, homolog of yeast Tim50