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The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Additionally we are shipping Translocation Protein 1 Proteins (7) and Translocation Protein 1 Kits (4) and many more products for this protein.
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Human Polyclonal TLOC1 Primary Antibody for EIA, IHC (p) - ABIN954706
Jung, Kindich, Kamradt, Jung, Müller, Schulz, Engers, Unteregger, Stöckle, Zimmermann, Wullich: Genomic and expression analysis of the 3q25-q26 amplification unit reveals TLOC1/SEC62 as a probable target gene in prostate cancer. in Molecular cancer research : MCR 2006
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Human Polyclonal TLOC1 Primary Antibody for EIA, IF - ABIN1450053
Deshaies, Schekman: SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum. in The Journal of cell biology 1990
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Human Polyclonal TLOC1 Primary Antibody for ICC, IF - ABIN4352423
Jadhav, McKenna, Johnson, High, Sinning, Pool: Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation. in Nature communications 2015
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these studies identify TLOC1 and SKIL (show SKIL Antibodies) as driver genes at 3q26 and more broadly suggest that cooperating genes may be coamplified in other regions with somatic copy number gain.
Sec62 overproduction significantly correlates with reduced non-small lung cancer patient survival.
Phosphorylation of Sec63 (show SEC63 Antibodies) by CK2 (show CSNK2A1 Antibodies) enhanced its binding to Sec62
Silencing the SEC62 gene inhibits post-translational transport of small presecretory proteins into endoplasmic reticulum.
the Sec62-dependent translocation pathway serves as a fail-safe mechanism to ensure efficient secretion of small proteins and provides cells with an opportunity to regulate secretion of small proteins independent of the signal recognition particle pathway
These results revealed that cyclin B1 (show CCNB1 Antibodies) and Sec62 may be candidate biomarkers and potential therapeutic targets for HBV-related HCC (show FAM126A Antibodies) recurrence after surgery.
The results indicate that SEC62 represents a potential candidate oncogene (show RAB1A Antibodies) in the amplified 3q region in cases of non-small cell lung cancer.
Our data indicate a crucial function of Sec62 in the response to thapsigargin-induced endoplasmic reticulum stress.
after silencing of SEC62 the cell migration and the invasive potential of the cells was blocked or at least dramatically reduced while cell viability was hardly affected. SEC62 gene may indeed be considered a target gene in the therapy of various tumors
The gene TLOC1/SEC62 revealed the highest frequency (50%) of copy number gains in the prostate cancer and was found to be up-regulated at the mRNA level.
Interaction of ribosomes and Sec62 with the core Sec61 (show SEC61A1 Antibodies) translocon is mutually exclusive.
The Sec62 protein plays a role in post-translational transport of presecretory proteins into endoplasmic reticulum.
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.
translocation protein 1
, translocation protein SEC62
, uncharacterized protein LOC696989
, hypothetical protein
, membrane protein SEC62, S.cerevisiae, homolog of