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The protein encoded by TM4SF1 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Additionally we are shipping TM4SF1 Proteins (3) and many more products for this protein.
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Human Polyclonal TM4SF1 Primary Antibody for IHC (p), WB - ABIN656640
Wang, Bao, Zhang, Cui, Shi: Transmembrane-4-L-six-family-1, a potential predictor for poor prognosis, overexpressed in human glioma. in Neuroreport 2015
High TM4SF1 expression is associated with esophageal cancer.
Replacement of the transmembrane 4 L six family protein TM4SF1 or TM4SF4 C-terminus with that of TM4SF5 increased spheroids growth, transwell migration, and invasive dissemination from spheroids in 3D collagen gels.
Results indicate that the expression of transmembrane 4 L6 family member 1 (TM4SF1) is higher in pancreatic cancer tissues and pancreatic cancer cell lines than controls.
Results show that TM4SF1 expression is elevated in colorectal cancer (CRC (show CALR Antibodies)), and associated with tumor stage and lymph node metastasis. Also, miR (show MLXIP Antibodies)-9 directly targeted its binding site in the TM4SF1 3'-UTR (show UTS2R Antibodies), which has a critical role in regulating CRC (show CALR Antibodies) cell migration. and invasion. Furthermore, miR (show MLXIP Antibodies)-9 regulated cell motility via suppressing
The findings suggest that TM4SF1 is a surface membrane antigen that is highly expressed in pancreatic cancer cells and increases the chemoresistance to gemcitabine. TM4SF1 may be a promising target to overcome the chemoresistance of pancreatic cancer.
TM4SF1 overexpression significantly contributed MDA-MB-231 cell migration but decreased apoptotic cells
Study shows that TM4SF1 expression is associated with better prognosis in pancreatic cancer. Its loss contributes to the invasion and migration of pancreatic cancer cells.
We found that miR (show MLXIP Antibodies)-203 was significantly downregulated in OSF (show OSTF1 Antibodies) tissues compared to that in normal buccal mucosa tissues, and that miR (show MLXIP Antibodies)-203 negatively regulated secreted SFRP4 (show SFRP4 Antibodies) and positively regulated TM4SF1
These findings validate TM4SF1 as an attractive candidate for cancer therapy with antibody-bound toxins that have the capacity to react with either cytoplasmic or nuclear targets in tumor cells or tumor-associated vascular endothelium.
TM4SF1 is a small plasma membrane glycoprotein (show CD86 Antibodies) that regulates cell motility and proliferation, and possibly a new vascular therapeutic target in cancer
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.
transmembrane 4 L six family member 1
, transmembrane 4 superfamily member 1
, transmembrane 4 L6 family member 1
, membrane component chromosome 3 surface marker 1
, membrane component, chromosome 3, surface marker 1
, tumor-associated antigen L6
, Tumor-associated antigen L6 homolog
, 12A8 target antigen
, L6 antigen
, membrane component chromosome 3 surface marker 1 homolog
, membrane component, surface marker 1