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TM7SF4 encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. Additionally we are shipping and many more products for this protein.
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TM7SF4 plays an essential role in regulating cell cycle progression in breast cancer.
The EP in TKA differed from EP in aseptically failed THA by lower CCL3 (show CCL3 Antibodies) and DC-STAMP mRNA and protein expression. EP of all studied inflammatory and osteoclastogenic molecules were similar in knee and hip OA.
Rs62620995 in the TM7SF4 gene was found to have a marginal association with Paget's disease of bone in the French-Canadian population.
DC-STAMP inhibition by RNA interference consequently suppressed fusion and bone resorption of human osteoclasts.
An interaction between OS9 (show OS9 Antibodies) and DC-STAMP was confirmed by yeast-2-hybrid analysis and cellular colocalization.ER-to-Golgi translocation of DC-STAMP following TLR stimulation in CHO (show COL11A1 Antibodies) cells was demonstrated, involving the DC-STAMP/OS9 (show OS9 Antibodies) interaction. The data indicate that OS9 (show OS9 Antibodies) is critically involved in ER-to-Golgi transport of DC-STAMP, and may be important in both myeloid differentiation and cell fusion.
DC-STAMP is an ITIM-bearing molecule. Based on the 4 distinct patterns of DCSTAMP on human PBMC, it has potential to serve as a susceptible biomarker of psoriasis (Ps) as well as severity marker of Psoriatic Arthritis (PsA (show PLAG1 Antibodies)).
Results show that T cells played a pivotal role in a new in vitro Langhans giant cells (LGCs) formation system, in which DC-STAMP was involved, and occurred via a molecular mechanism that involved CD40 (show CD40 Antibodies)-CD40L (show CD40LG Antibodies) interaction and IFN-gamma (show IFNG Antibodies) secretion.
genetic risk for Paget's disease of bone is associated with variants close to CSF1 (show CSF1 Antibodies), OPTN (show OPTN Antibodies), TM7SF4, and TNFRSF11A (show TNFRSF11A Antibodies) genes
DC-STAMP interacts with ER-resident transcription factor LUMAN (show CREB3 Antibodies) which becomes activated during DC maturation.
The dendritic cell-specific transmembrane protein is a multimembrane-spanning protein preferentially expressed by human DC (hDC (show HDC Antibodies)).
These results suggest that Luman (show CREB3 Antibodies) regulates the multinucleation of osteoclasts by promoting cell fusion of mononuclear osteoclasts through DC-STAMP induction and intracellular distribution during osteoclastogenesis.
miR (show MLXIP Antibodies)-7b inhibits osteoclastogenesis and cell-cell fusion by directly targeting DC-STAMP.
our data indicate that Pin1 (show PIN1 Antibodies) is a determinant of bone mass through the regulation of the osteoclast fusion protein DC-STAMP
Mechanical vibration of osteoclast precursor cells reduces DC-STAMP expression in osteoclast precursor cells.
DC-STAMP, Siglec-15 (show SIGLEC15 Antibodies), Tspan7 (show TSPAN7 Antibodies) and Mst1r (show MST1R Antibodies) expression was downregulated by docosahexaenoic acid, but not eicosapentaenoic acid during osteoclastogenesis in vitro.
Results indicate that NFATc1 (show NFATC1 Antibodies) binding to the DC-STAMP promoter was inhibited by 60.9% with RvE1 treatment.
Strawberry notch (show NOTCH1 Antibodies) homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.
These results suggest that short-term mechanical stress strongly inhibits osteoclastogenesis through the downregulation of DC-STAMP.
Fusogenic mechanisms in macrophage-lineage cells are regulated via OC-STAMP and DC-STAMP.
found that DC-STAMP, a key regulator of osteoclast cell fusion, is a direct target gene of Tal1 (show TAL1 Antibodies) and show that Tal1 (show TAL1 Antibodies) represses DC-STAMP expression by counteracting the activating function of the transcription factors PU.1 and MITF (show MITF Antibodies)
This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants.
transmembrane 7 superfamily member 4
, dendritic cell-specific transmembrane protein
, DC-specific transmembrane protein
, Dendritic cells (DC)-specific transmembrane protein
, IL-4-induced protein
, IL-Four (IL-4) induced
, IL-Four INDuced
, IL-four-induced protein
, dendrocyte-expressed seven transmembrane protein