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anti-Transmembrane Channel-Like 1 (TMC1) Antibodies

TMC1 is considered a member of a gene family predicted to encode transmembrane proteins. Additionally we are shipping TMC1 Proteins (6) and TMC1 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TMC1 117531 Q8TDI8
TMC1 361739  
TMC1 13409 Q8R4P5
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Top anti-TMC1 Antibodies at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Reactivity Host Conjugate Application Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Sheep Un-conjugated IHC, WB 100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated ELISA, WB 50 μL Log in to see 9 to 11 Days
$313.50
Details
Human Rabbit Un-conjugated ELISA, WB 50 μL Log in to see 16 to 21 Days
$714.29
Details
Human Rabbit Un-conjugated 50 μL Log in to see 9 to 19 Days
$417.00
Details
Mouse Rabbit Un-conjugated WB 100 μL Log in to see 9 to 19 Days
$448.47
Details

TMC1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human
,

Rat (Rattus)


Mouse (Murine)
,

Top referenced anti-TMC1 Antibodies

  1. Human Polyclonal TMC1 Primary Antibody for IHC, WB - ABIN351009 : Carninci, Kasukawa, Katayama, Gough, Frith, Maeda, Oyama, Ravasi, Lenhard, Wells, Kodzius, Shimokawa, Bajic, Brenner, Batalov, Forrest, Zavolan, Davis, Wilming, Aidinis, Allen, Ambesi-Impiombato et al.: The transcriptional landscape of the mammalian genome. ... in Science (New York, N.Y.) 2005 (PubMed)
    Show all 7 references for ABIN351009

  2. Human Polyclonal TMC1 Primary Antibody for IHC, WB - ABIN351044 : Humphray, Oliver, Hunt, Plumb, Loveland, Howe, Andrews, Searle, Hunt, Scott, Jones, Ainscough, Almeida, Ambrose, Ashwell, Babbage, Babbage, Bagguley, Bailey, Banerjee, Barker, Barlow, Bates, Beasley et al.: DNA sequence and analysis of human chromosome 9. ... in Nature 2004 (PubMed)
    Show all 7 references for ABIN351044

  3. Human Polyclonal TMC1 Primary Antibody for IHC, WB - ABIN351041 : Keresztes, Mutai, Heller: TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. in BMC genomics 2003 (PubMed)
    Show all 7 references for ABIN351041

  4. Human Polyclonal TMC1 Primary Antibody for IHC, WB - ABIN351040 : Kurima, Yang, Sorber, Griffith: Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. in Genomics 2003 (PubMed)
    Show all 7 references for ABIN351040

More Antibodies against TMC1 Interaction Partners

Human Transmembrane Channel-Like 1 (TMC1) interaction partners

  1. a novel TMC1 mutation in exon 20, c.1979C>T, p.P660L, which segregated with prelingual autosomal recessive sensorineural hearing loss, was found.

  2. there is hypo-functional TMC1 mechanotransduction channel activity and other even less damaging variants of TMC1 may be associated with more common mild-to-severe sensorineural hearing loss.

  3. TMC1 has been identified as the causative gene in a six-generation Chinese family with autosomal dominant hearing loss.

  4. The first mutation in the TMC1 gene in the Moroccan population causing non-syndromic hearing loss.

  5. The novel compound heterozygous mutant alleles of TMC1 identified in this study were responsible for the autosomal recessive non-syndromic hearing loss in this Tibetan Chinese family.

  6. one heterozygous, non-synonymous variant was detected, with the SNP causing an amino acid substitution in TMC1 in a Polish family with hearing impairment

  7. TMC1 mutations disrupt hair cell mechanoelectrical transduction and are responsible for DFNA36 and DFNB7/B11. [Review Article]

  8. TMC1 is expressed in the hair cells in inner ear.

  9. Description of the spectrum of mutations in TMC1 in 374 families with autosomal recessive, non-syndromic hearing loss from India.

  10. hearing loss in this family was caused by novel compound heterozygous mutations in TMC1

Mouse (Murine) Transmembrane Channel-Like 1 (TMC1) interaction partners

  1. TMC1 and TMC2 are components of the stereocilia mechanoelectrical transduction channel complex.

  2. The results suggest that a major component of channel adaptation is regulated by changes in intracellular Ca(2 (show CA2 Antibodies)+).

  3. This study demonstrated that the M412K point mutation in TMC1 of Beethoven mice leads to a reduced Ca2 (show CA2 Antibodies)+ permeability, more so in Tmc1Bth/Bth than in Tmc1Bh/+, and conductance of the MET channel of Mouse Outer Hair Cells.

  4. gene augmentation with Tmc1 or Tmc2 is well suited for further development as a strategy for restoration of auditory function in deaf patients who carry TMC1 mutations

  5. During the first postnatal week, we observed a normal mechanotransducer current in hair cells lacking Tmc1 or Tmc2; however, in the absence of both isoforms, we recorded a large MT current that was phase-shifted 180 degrees .

  6. This study demonstrate TMC1 is components of hair cell transduction channels and contribute to permeation properties.

  7. Tmc1 is expressed in mouse vestibular & cochlear hair cells near the stereocilia tips. Deletion of Tmc1 & Tmc2 causes deafness. Restoration of Tmc1 rescues mechanotransduction.

  8. Tmc1 was present within the endoplasmic reticulum as an integral membrane protein containing six transmembrane domains and cytosolic N- and C-termini.

TMC1 Antigen Profile

Protein Summary

This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown\; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness.

Gene names and symbols associated with TMC1

  • transmembrane channel-like 1 (TMC1) antibody
  • transmembrane channel-like 1 (LOC100359097) antibody
  • transmembrane channel-like 1 (Tmc1) antibody
  • transmembrane channel-like gene family 1 (Tmc1) antibody
  • 4933416G09Rik antibody
  • Beethoven antibody
  • Bth antibody
  • CWEA1 antibody
  • DFNA36 antibody
  • DFNB7 antibody
  • DFNB11 antibody
  • dn antibody

Protein level used designations for TMC1

transmembrane channel-like protein 1 , transmembrane channel-like 1 , transmembrane channel-like protein 1-like , transmembrane cochlear-expressed protein 1 , transmembrane, cochlear expressed, 1 , transmembrane channel-like gene family 1 , deafness protein , transmembrane, cochlear expressed 1

GENE ID SPECIES
427255 Gallus gallus
472952 Pan troglodytes
484168 Canis lupus familiaris
538406 Bos taurus
704827 Macaca mulatta
100359097 Oryctolagus cuniculus
100445594 Pongo abelii
100516949 Sus scrofa
100581932 Nomascus leucogenys
117531 Homo sapiens
361739 Rattus norvegicus
13409 Mus musculus
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