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Transmembrane Channel-Like 8 Proteins (TMC8)

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. Additionally we are shipping TMC8 Antibodies (62) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TMC8 147138 Q8IU68
Rat TMC8 TMC8 688276  
TMC8 217356 Q7TN58
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Top TMC8 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

TMC8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Transmembrane Channel-Like 8 (TMC8) Interaction Partners

Human Transmembrane Channel-Like 8 (TMC8) interaction partners

  1. Findings suggest that SNPs in EVER2 may be involved in the development of premalignant skin lesions that harbour beta-HPV, perhaps giving rise to SCC (show CYP11A1 Proteins) tumours that have lost beta-HPV gene expression during progression.

  2. TMC6/EVER1 (show TMC6 Proteins) and TMC8/EVER2 are known to be involved in the development of EV.

  3. A common genetic variation in TMC8 is associated with high-risk HPV infection and head and neck squamous cell carcinoma etiology.

  4. We found a possible correlation between the EVER2 TT genotype and the development of AK, suggesting a potential role of this polymorphism in the development of AK.

  5. EV is also a rare autosomal recessive genodermatosis involving susceptibility to human papillomavirus (HPV) infections and squamous cell carcinoma, caused in most cases by homozygous mutations in EVER1 (show TMC6 Proteins) or EVER2.

  6. TMC8 was found to be localized in the endoplasmic reticulum (ER), where it inhibited receptor mediated Ca(2 (show CA2 Proteins)+) release, activation of Ano1 (show ANO1 Proteins) and volume regulated LRRC8 (show LRRC8A Proteins)-related Cl(-) currents.

  7. Expression of both EVER1 (show TMC6 Proteins) and EVER2 in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed by latent membrane protein 1-activated NF-kappaB (show NFKB1 Proteins) signaling.

  8. Loss of the HPV-infection resistance EVER2 protein impairs NF-kappaB (show NFKB1 Proteins) signaling pathways in keratinocytes.

  9. Ever2 interacts with the N-terminal domain of TRADD (show TRADD Proteins), impairs the recruitment of TRAF2 (show TRAF2 Proteins) and RIPK1 (show RIPK1 Proteins) and promotes apoptosis.

  10. EVER2-deficient patients display mild T-cell abnormalities: a significant increase of memory CD4 (show CD4 Proteins)+ and effector memory CD8 (show CD8A Proteins)+ T cells, a bias of the T cell receptor Valphabeta and Vgammadelta repertoires and an increase of skin-homing CD4 (show CD4 Proteins)+ T-cell subsets.

TMC8 Protein Profile

Protein Summary

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs.

Gene names and symbols associated with TMC8

  • transmembrane channel-like 8 (TMC8)
  • transmembrane channel-like 8 (Tmc8)
  • transmembrane channel-like gene family 8 (Tmc8)
  • EV2 protein
  • Ever2 protein
  • EVIN2 protein
  • mFLJ00400 protein

Protein level used designations for TMC8

transmembrane channel-like 8 , FLJ00400 protein-like , transmembrane channel-like protein 8-like , epidermodysplasia verruciformis 2 , epidermodysplasia verruciformis protein 2 , transmembrane channel-like protein 8 , uncharacterized protein LOC688276 , epidermodysplasia verruciformis protein 2 homolog

GENE ID SPECIES
483342 Canis lupus familiaris
513813 Bos taurus
100031099 Monodelphis domestica
100443950 Pongo abelii
100478575 Ailuropoda melanoleuca
100596943 Nomascus leucogenys
100615612 Pan troglodytes
147138 Homo sapiens
688276 Rattus norvegicus
217356 Mus musculus
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