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TMED10 is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. Additionally we are shipping TMED10 Proteins (6) and many more products for this protein.
Showing 10 out of 117 products:
Human Polyclonal TMED10 Primary Antibody for EIA, IHC (p) - ABIN500992
Selkoe: The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. in Trends in cell biology 1999
Show all 4 references for ABIN500992
Human Polyclonal TMED10 Primary Antibody for EIA, IHC (p) - ABIN500990
Chen, Hasegawa, Schmitt-Ulms, Kawarai, Bohm, Katayama, Gu, Sanjo, Glista, Rogaeva, Wakutani, Pardossi-Piquard, Ruan, Tandon, Checler, Marambaud, Hansen, Westaway, St George-Hyslop, Fraser: TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. in Nature 2006
Show all 3 references for ABIN500990
Chicken Polyclonal TMED10 Primary Antibody for WB - ABIN2787806
Dolcini, Dunys, Sevalle, Chen, Guillot-Sestier, St George-Hyslop, Fraser, Checler: TMP21 regulates Abeta production but does not affect caspase-3, p53, and neprilysin. in Biochemical and biophysical research communications 2008
TMP21 modulates cell growth in papillary thyroid cancer cells by inducing autophagy, which may be associated with activation of AMPK (show PRKAA1 Antibodies)/mTOR (show FRAP1 Antibodies) pathway.
Study demonstrates that NleF binds to the human Tmp21 protein and subsequently disrupts intracellular protein (show CKAP2 Antibodies) trafficking.
Data show that the level of p23 expression is critical for neuronal function, and p23 overexpression initiates a cascade in brainstem that leads to severe motor deficits and other neurological problems, culminating in premature death.
Results suggest that Tmp21 is a novel protein that preferentially binds to Beta(2)-microglobulin-free MHC-I heavy chains.
p23 acts as an anchoring protein that retains PKCdelta (show PKCd Antibodies) at the perinuclear region, thus limiting the availability of this kinase for activation in response to stimuli.
Transmembrane protein 23 (show SGMS1 Antibodies) and p24A differentially control G-protein coupled receptor (show ADRA1A Antibodies) trafficking and signaling in astrocytes.
These results demonstrate that p23/Tmp21 acts as an anchor that distinctively modulates compartmentalization of C1 domain-containing proteins, and it plays an essential role in beta2-chimaerin (show CHN1 Antibodies) relocalization.
TMP21, a member of the p24 cargo protein family, is a component of presenilin complexes and differentially regulates gamma-secretase cleavage without affecting epsilon-secretase activity
TMP21 behaves as a regulator of gamma- but not epsilon-cleavages of beta-amyloid precursor protein generated by presenilin-dependent gamma-secretase complex.
p23 is widely distributed throughout the frontal cortex, hippocampus and cerebellum of control and Alzheimer disease (AD)brains; steady-state p23 levels are reduced in the brains of individuals with AD.
These findings suggest that a fraction of p23 (show CDK5R1 Antibodies) enters post-Golgi compartments and may function in the biogenesis and/or quality control of SGs (show SKI Antibodies).
High levels of p23 (show CDK5R1 Antibodies) expression are found in embryonic mouse brain, but the steady-state p23 (show CDK5R1 Antibodies) levels gradually decline after birth to the lower adult level.
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.
transmembrane protein tmp21
, 21 kDa transmembrane trafficking protein
, 21 kDa transmembrane-trafficking protein
, p24 family protein delta-1
, transmembrane emp24 domain-containing protein 10
, transmembrane protein Tmp21
, transmembrane trafficking protein
, integral membrane protein Tmp21-I (p23)
, transmembrane trafficking protein 21
, p24 delta 1
, integral membrane protein p23