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TMPRSS2 encodes a protein that belongs to the serine protease family. Additionally we are shipping TMPRSS2 Kits (14) and TMPRSS2 Proteins (11) and many more products for this protein.
Showing 10 out of 65 products:
Human Polyclonal TMPRSS2 Primary Antibody for EIA, WB - ABIN453423
Gopalan, Leversha, Satagopan, Zhou, Al-Ahmadie, Fine, Eastham, Scardino, Scher, Tickoo, Reuter, Gerald: TMPRSS2-ERG gene fusion is not associated with outcome in patients treated by prostatectomy. in Cancer research 2009
Show all 2 references for ABIN453423
Human Polyclonal TMPRSS2 Primary Antibody for EIA, WB - ABIN453424
Hofer, Kuefer, Maier, Herkommer, Perner, Demichelis, Paiss, Vogel, Rubin, Hoegel: Genome-wide linkage analysis of TMPRSS2-ERG fusion in familial prostate cancer. in Cancer research 2009
Show all 2 references for ABIN453424
Human Polyclonal TMPRSS2 Primary Antibody for ELISA, WB - ABIN449738
Tomlins, Laxman, Dhanasekaran, Helgeson, Cao, Morris, Menon, Jing, Cao, Han, Yu, Wang, Montie, Rubin, Pienta, Roulston, Shah, Varambally, Mehra, Chinnaiyan: Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer. in Nature 2007
Studies showed that urinary TMPRSS2:ERG (show ERG Antibodies) transcripts seem to be indicative of Prostate cancer aggressiveness upon biopsy. [review]
Aspirin was associated with a significant reduction in the relative risk of TMPRSS2:ERG (show ERG Antibodies) (T2E )fusion positive, but not T2E negative
the type II transmembrane serine protease (show TMPRSS11E Antibodies) TMPRSS2 was able to activate hemagglutinin (show HA Antibodies) for cell entry indicating that bat (show BAAT Antibodies) influenza A virus can utilize human proteases for hemagglutinin (show HA Antibodies) activation.
The relatively low rate of ERG (show ERG Antibodies)-positive prostatic intraepithelial neoplasia counts in favor of the limited role of chimeric transcript TMPRSS2/ERG (show ERG Antibodies) in the differential diagnosis of prostatic intraepithelial neoplasia
TMPRSS2 isoform 1 is expressed in viral target cells.
The TMPRSS2-ERG (show ERG Antibodies) Gene Fusion Blocks XRCC4 (show XRCC4 Antibodies)-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP (show COL11A2 Antibodies) Inhibition
The potential for TMPRSS2:ERG (show ERG Antibodies) gene fusion, detected by IHC, to modify the role of PTEN (show PTEN Antibodies) loss in lethal progression of prostate cancer.
Results indicate that PTEN (show PTEN Antibodies) loss occurs in cooperation with TMPRSS2-ERG fusion in prostate cancer and the majority of the samples harbor TMPRSS2-ERG fusion as well as PTEN (show PTEN Antibodies) gene deletion.
Elucidation of ERG (show ERG Antibodies) regulation of ABEs in castration-resistant prostate cancer (CRPC) may help to stratify TMPRSS2-ERG fusion-positive prostate cancer patients in the clinic for anti-androgen receptor (show AR Antibodies)-driven therapies.
these data show that the androgen-driven events causing TMPRSS2-ERG (show ERG Antibodies) fusions and other rearrangements of androgen-dependent genes in prostate epithelial cells of young patients preferentially lead to low-grade (and not high-grade) prostate cancer.
Genetic inhibition of TMPRSS2-ERG (show ERG Antibodies) junction oncogene (show RAB1A Antibodies) in prostate cancer by means of siRNA has strong antineoplastic effect in a mouse model and in vitro.
The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis
TMPRSS2 as a host cell factor essential for viral spread and pathogenesis of mono-basic H1N1 and H3N2 influenza A viruses.
These results demonstrate that TMPRSS2 expression is essential for influenza A virus replication in vivo.
These data demonstrate that TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 and H1N1 influenza virus in mice.
Loss of TMPRSS2 serine protease (show F2 Antibodies) activity does not influence fertility, reduce survival, result in prostate hyperplasia or carcinoma, or alter prostatic luminal epithelial cell regrowth following castration and androgen replacement.
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, serine protease 10
, transmembrane protease serine 2
, plasmic transmembrane protein X