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TMEM165 encodes a predicted transmembrane protein with a perinuclear Golgi-like distribution in fibroblasts. Additionally we are shipping TMEM165 Antibodies (16) and and many more products for this protein.
Decreased expression of several markers of cartilage and bone development suggests that Tmem165 deficiency alters both chondrocyte and osteoblast differentiation.
Data indicate the Golgi protein (show GOLPH3 ELISA Kits) transmembrane protein 165 (TMEM165) as a manganese-sensitive protein in mammalian cells.
This manuscript is a review of the current state of knowledge on TMEM165 deficiencies in Congenital Disorders of Glycosylation as well as new data on function of TMEM165 and some speculative models on TMEM165/Golgi functions are discussed.
Study not only provides novel insights into the molecular causes of glycosylation defects observed in TMEM165-deficient cells but also suggests that TMEM165 is a key determinant for the regulation of Golgi Mn(2+) homeostasis.
Antisense oligonucleotide-mediated pseudoexon skipping used in a Golgi-resident protein, a promising treatment option for a specific TMEM165-congenital disorders of glycosylation.
Congenital Disorders of Glycosylation disease-causing mutations of TMEM165 changes subcellular localization of the protein.
Defects in TMEM165 affect both Ca2 (show CA2 ELISA Kits)+ and pH homeostasis.
we identified TMEM165 (also named TPARL) as a gene involved in congenital disorders of glycosylation (CDG).
The timing, magnitude of TMEM165 expression and its Golgi location supports a role for this Golgi Ca2 (show CA2 ELISA Kits)+/H+ antiporter as a contributor to mammary Golgi calcium transport needs, in addition to the better-characterized roles of SPCA1 (show ATP2C1 ELISA Kits) and 2.
This gene encodes a predicted transmembrane protein with a perinuclear Golgi-like distribution in fibroblasts. Mutations in this gene are associated with the autosomal recessive disorder congenital disorder of glycosylation, type IIk. Knockdown of this gene's expression causes decreased sialylation in HEK cells and suggests this gene plays a role in terminal Golgi glycosylation. Alternative splicing results in multiple transcript variants.
TPA regulated locus
, transmembrane protein 165
, transmembrane protein PT27
, transmembrane protein TPARL
, TPA-regulated locus protein
, transmembrane protein 164
, transmembrane protein PFT27