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anti-Transmembrane Protein 173 (TMEM173) Antibodies

Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Additionally we are shipping TMEM173 Proteins (10) and TMEM173 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TMEM173 340061 Q86WV6
TMEM173 72512 Q3TBT3
TMEM173 498840  
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Top anti-TMEM173 Antibodies at antibodies-online.com

Showing 10 out of 115 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-TMEM173 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB TM173 Antibody (C-term) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. TM173 Antibody (C-term) IHC analysis in formalin fixed and paraffin embedded breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TM173 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, FACS, WB TM173 Antibody (C-term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Western blot analysis of TM173 Antibody (C-term) in mouse spleen tissue lysates (35 µg/lane). TM173 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IF, WB Immunocytochemistry of MPYS in A20 cells with MPYSat 5 μg/ml. Western blot analysis of MPYS in A-20 cell lysate with AP30565PU-N MPYS antibody at 1 µg/ml (A) and 2 μg/ml (B). 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB Host: Rabbit  Target Name: Tmem173  Sample Tissue: Rat Spleen lysates  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated FACS, WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated IHC (p), WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details

TMEM173 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-TMEM173 Antibodies

  1. Human Polyclonal TMEM173 Primary Antibody for EIA, FACS - ABIN955253 : Sun, Li, Chen, Chen, You, Zhou, Zhou, Zhai, Chen, Jiang: ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. in Proceedings of the National Academy of Sciences of the United States of America 2009 (PubMed)
    Show all 4 references for ABIN955253

  2. Human Polyclonal TMEM173 Primary Antibody for WB - ABIN2783202 : Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ... in Genome research 2004 (PubMed)
    Show all 4 references for ABIN2783202

  3. Human Polyclonal TMEM173 Primary Antibody for EIA, FACS - ABIN955254 : Zhong, Zhang, Lei, Li, Mao, Yang, Wang, Zhang, Shu: The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. in Immunity 2009 (PubMed)
    Show all 2 references for ABIN955254

  4. Human Polyclonal TMEM173 Primary Antibody for EIA, IF - ABIN500288 : Zhong, Yang, Li, Wang, Li, Diao, Lei, He, Zhang, Tien, Shu: The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. in Immunity 2008 (PubMed)
    Show all 2 references for ABIN500288

More Antibodies against TMEM173 Interaction Partners

Human Transmembrane Protein 173 (TMEM173) interaction partners

  1. Studies suggest that the transmembrane protein 173 (STING) pathway is the main innate immune pathway involved in sensing of tumors, and its endogenous activation in APCs (show APCS Antibodies) leads to subsequent T cell priming against tumor-associated antigens.

  2. A STING-dependent, cGAS-independent pathway important for full interferon (show IFNA Antibodies) production and antiviral control of enveloped RNA viruses.

  3. Studies indicate that the STING (stimulator of interferon (show IFNA Antibodies) genes)-controlled innate immune pathway has provided insight for treating autoinflammatory disease and cancer.

  4. This study demonstrates that E2 proteins of high risk human papillomavirus reduce STING and IFN-kappa transcription.

  5. Results reveal a critical role of STING in regulating dsDNA-triggered activation of the JAK1 (show JAK1 Antibodies)-STAT1 (show STAT1 Antibodies) signaling in B cells and highlight the close associations of STING low-expression with JAK1 (show JAK1 Antibodies)-STAT1 (show STAT1 Antibodies) signaling in systemic lupus erythematosus B cells.

  6. Data identifies a single amino acid change in STING that leads to its constitutive activation of downstream signaling, by increasing its propensity to dimerize and associate with TBK1 (show TBK1 Antibodies).

  7. findings demonstrate a novel regulatory circuit in which STING and TBK1 (show TBK1 Antibodies) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A (show PPM1A Antibodies) dephosphorylates STING and TBK1 (show TBK1 Antibodies)

  8. STING(sv) inhibited the activity of the interferon (show IFNA Antibodies) (IFN)-beta (show IFNB1 Antibodies) promoter.

  9. Cyclic GMP (show NT5C2 Antibodies)-AMP (show APRT Antibodies), but not its linkage isomers, adopts an organized free-ligand conformation that resembles the STING-bound conformation and pays low entropy and enthalpy costs in converting into the active conformation.

  10. stimulation of STING-dependent IRF3 (show IRF3 Antibodies) activation by UV is due to apoptotic signaling-dependent disruption of ULK1 (Unc51 (show ULK1 Antibodies)-like kinase 1), a pro-autophagic protein that negatively regulates STING

Mouse (Murine) Transmembrane Protein 173 (TMEM173) interaction partners

  1. Data show that the formation of a tripartite ribosomal protein S6 kinase 1 (S6K1 (show RPS6KB1 Antibodies))-STING membrane protein-TANK-binding kinase 1 (TBK1 (show TBK1 Antibodies)) complex was necessary for the activation of interferon regulatory factor-3 (IRF3 (show IRF3 Antibodies)).

  2. Sting protein role in the innate immune response and interferon (show IFNA Antibodies)-stimulated genes response pathway

  3. required for chitosan-mediated enhancement of antigen specific Th1 (show HAND1 Antibodies) and immunoglobulin G2 responses following vaccination

  4. in vitro activation of the AIM2 (show AIM2 Antibodies) inflammasome in murine macrophages and dendritic cells leads to reduced activation of the STING pathway, in part through promoting caspase-1 (show CASP1 Antibodies)-dependent cell death.

  5. A STING-dependent, cGAS-independent pathway important for full interferon (show IFNA Antibodies) production and antiviral control of enveloped RNA viruses.

  6. the G37S mutation of RNaseH2 led to increased expression of interferon (show IFNA Antibodies)-stimulated genes dependent on the cGAS-STING signaling pathway.

  7. enforced activation of STING by intratumoral injection of cyclic dinucleotide GMP (show NT5C2 Antibodies)-AMP (show TMPRSS5 Antibodies) (cGAMP), potently enhanced antitumor CD8 (show CD8A Antibodies) T responses.

  8. Results reveal a critical role of STING in regulating dsDNA-triggered activation of the JAK1 (show JAK1 Antibodies)-STAT1 (show STAT1 Antibodies) signaling in B cells and highlight the close associations of STING low-expression with JAK1 (show JAK1 Antibodies)-STAT1 (show STAT1 Antibodies) signaling in systemic lupus erythematosus B cells.

  9. findings demonstrate a novel regulatory circuit in which STING and TBK1 (show TBK1 Antibodies) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A (show PPM1A Antibodies) dephosphorylates STING and TBK1 (show TBK1 Antibodies)

  10. c-di-GMP (show NT5C2 Antibodies) comprehensively regulated both HSPCs and their niche cells through an innate immune sensor, STING, thereby inducing entry into the cell cycle and mobilization of HSPCs

Pig (Porcine) Transmembrane Protein 173 (TMEM173) interaction partners

TMEM173 Antigen Profile

Protein Summary

Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.

Gene names and symbols associated with TMEM173

  • transmembrane protein 173 (TMEM173) antibody
  • transmembrane protein 173 (Tmem173) antibody
  • 2610307O08Rik antibody
  • ERIS antibody
  • Mita antibody
  • MPYS antibody
  • NET23 antibody
  • RGD1562552 antibody
  • STING antibody

Protein level used designations for TMEM173

transmembrane protein 173 , N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner , endoplasmic reticulum IFN stimulator , endoplasmic reticulum interferon stimulator , hMITA , hSTING , mediator of IRF3 activation , mitochondrial mediator of IRF3 activation , stimulator of interferon genes protein , MMITA , mSTING , Stimulator of interferon genes protein , mitochondrial transmembrane protein 173

GENE ID SPECIES
606815 Canis lupus familiaris
462107 Pan troglodytes
694353 Macaca mulatta
100459760 Pongo abelii
340061 Homo sapiens
72512 Mus musculus
533661 Bos taurus
768990 Gallus gallus
100217389 Sus scrofa
498840 Rattus norvegicus
Selected quality suppliers for anti-TMEM173 (TMEM173) Antibodies
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