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Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Additionally we are shipping TMEM173 Proteins (10) and TMEM173 Kits (4) and many more products for this protein.
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Human Polyclonal TMEM173 Primary Antibody for WB - ABIN2783202
Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ... in Genome research 2004
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Human Polyclonal TMEM173 Primary Antibody for EIA, FACS - ABIN955253
Sun, Li, Chen, Chen, You, Zhou, Zhou, Zhai, Chen, Jiang: ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. in Proceedings of the National Academy of Sciences of the United States of America 2009
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Human Polyclonal TMEM173 Primary Antibody for EIA, IF - ABIN500288
Zhong, Yang, Li, Wang, Li, Diao, Lei, He, Zhang, Tien, Shu: The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. in Immunity 2008
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Human Polyclonal TMEM173 Primary Antibody for EIA, FACS - ABIN955254
Zhong, Zhang, Lei, Li, Mao, Yang, Wang, Zhang, Shu: The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. in Immunity 2009
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Studies suggest that the transmembrane protein 173 (STING) pathway is the main innate immune pathway involved in sensing of tumors, and its endogenous activation in APCs (show APCS Antibodies) leads to subsequent T cell priming against tumor-associated antigens.
A STING-dependent, cGAS-independent pathway important for full interferon (show IFNA Antibodies) production and antiviral control of enveloped RNA viruses.
Studies indicate that the STING (stimulator of interferon (show IFNA Antibodies) genes)-controlled innate immune pathway has provided insight for treating autoinflammatory disease and cancer.
This study demonstrates that E2 proteins of high risk human papillomavirus reduce STING and IFN-kappa transcription.
Results reveal a critical role of STING in regulating dsDNA-triggered activation of the JAK1 (show JAK1 Antibodies)-STAT1 (show STAT1 Antibodies) signaling in B cells and highlight the close associations of STING low-expression with JAK1 (show JAK1 Antibodies)-STAT1 (show STAT1 Antibodies) signaling in systemic lupus erythematosus B cells.
Data identifies a single amino acid change in STING that leads to its constitutive activation of downstream signaling, by increasing its propensity to dimerize and associate with TBK1 (show TBK1 Antibodies).
findings demonstrate a novel regulatory circuit in which STING and TBK1 (show TBK1 Antibodies) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A (show PPM1A Antibodies) dephosphorylates STING and TBK1 (show TBK1 Antibodies)
STING(sv) inhibited the activity of the interferon (show IFNA Antibodies) (IFN)-beta (show IFNB1 Antibodies) promoter.
Cyclic GMP (show NT5C2 Antibodies)-AMP (show APRT Antibodies), but not its linkage isomers, adopts an organized free-ligand conformation that resembles the STING-bound conformation and pays low entropy and enthalpy costs in converting into the active conformation.
stimulation of STING-dependent IRF3 (show IRF3 Antibodies) activation by UV is due to apoptotic signaling-dependent disruption of ULK1 (Unc51 (show ULK1 Antibodies)-like kinase 1), a pro-autophagic protein that negatively regulates STING
Data show that the formation of a tripartite ribosomal protein S6 kinase 1 (S6K1 (show RPS6KB1 Antibodies))-STING membrane protein-TANK-binding kinase 1 (TBK1 (show TBK1 Antibodies)) complex was necessary for the activation of interferon regulatory factor-3 (IRF3 (show IRF3 Antibodies)).
Sting protein role in the innate immune response and interferon (show IFNA Antibodies)-stimulated genes response pathway
required for chitosan-mediated enhancement of antigen specific Th1 (show HAND1 Antibodies) and immunoglobulin G2 responses following vaccination
in vitro activation of the AIM2 (show AIM2 Antibodies) inflammasome in murine macrophages and dendritic cells leads to reduced activation of the STING pathway, in part through promoting caspase-1 (show CASP1 Antibodies)-dependent cell death.
the G37S mutation of RNaseH2 led to increased expression of interferon (show IFNA Antibodies)-stimulated genes dependent on the cGAS-STING signaling pathway.
enforced activation of STING by intratumoral injection of cyclic dinucleotide GMP (show NT5C2 Antibodies)-AMP (show TMPRSS5 Antibodies) (cGAMP), potently enhanced antitumor CD8 (show CD8A Antibodies) T responses.
c-di-GMP (show NT5C2 Antibodies) comprehensively regulated both HSPCs and their niche cells through an innate immune sensor, STING, thereby inducing entry into the cell cycle and mobilization of HSPCs
Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
transmembrane protein 173
, N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
, endoplasmic reticulum IFN stimulator
, endoplasmic reticulum interferon stimulator
, mediator of IRF3 activation
, mitochondrial mediator of IRF3 activation
, stimulator of interferon genes protein
, Stimulator of interferon genes protein
, mitochondrial transmembrane protein 173