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The protein encoded by TMEM195 is a tetrahydrobiopterin- and iron-dependent enzyme that cleaves the ether bond of alkylglycerols. Additionally we are shipping Transmembrane Protein 195 Antibodies (13) and and many more products for this protein.
We identified homozygous and heterozygous mutations of the alkylglycerol monooxygenase (AGMO) gene (MIM 613738) as the likely cause of visceral leishmaniasis relapse in 3 families.
An AGMO mutation was found in a Saudi family underlying primary microcephaly and intellectual disability.
Transmembrane protein 195 has tetrahydrobiopterin-dependent alkylglycerol monooxygenase activity (also known as glyceryl-ether monooxygenase activity, E.C. 126.96.36.199).
These results demonstrate a central role of tetrahydrobiopterin and alkylglycerol monooxygenase in ether lipid metabolism of murine macrophages.
Results suggest a possible mechanism for Alkylglycerol monooxygenase (AGMO) in modulating macrophage platelet-activating factor (PAF (show KIAA0101 ELISA Kits)) production by regulating cellular lyso-PAF (show KIAA0101 ELISA Kits) levels.
The protein encoded by this gene is a tetrahydrobiopterin- and iron-dependent enzyme that cleaves the ether bond of alkylglycerols. Sequence comparisons distinguish this protein as forming a third, distinct class of tetrahydrobiopterin-dependent enzymes. Variations in this gene have been associated with decreased glucose-stimulated insulin response, type 2 diabetes, and susceptibility to intracranial aneurysms.
, transmembrane protein 195