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Transmembrane Protein 27 Proteins (TMEM27)

TMEM27 encodes a transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. Additionally we are shipping TMEM27 Antibodies (26) and TMEM27 Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TMEM27 57393 Q9HBJ8
TMEM27 57394 Q9ESG4
TMEM27 57395 Q9ESG3
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Top TMEM27 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$545.60
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,258.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,258.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$731.71
Details

TMEM27 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Transmembrane Protein 27 (TMEM27) Interaction Partners

Human Transmembrane Protein 27 (TMEM27) interaction partners

  1. Tmem27 is present in human serum and its levels are significantly lower in subjects with autoimmune diabetes as compared to healthy individuals.

  2. Bace2 (show BACE2 Proteins) specifically targets Tmem27 and cleaves its extracellular domain, which is then shed from the plasma membrane of pancreatic beta cells.

  3. Tmem27 dimerization is a dynamic process involving Bace2 (show BACE2 Proteins)

  4. Collectrin and ACE2 (show ACE2 Proteins) in renal and intestinal amino acid transport.

  5. Data support a role for TMEM27 in glucose-induced insulin (show INS Proteins) secretion but not in cell proliferation. The finding that its cleavage is not specific to beta cells challenges the current support for its use as a potential beta cell mass biomarker.

  6. Collectrin has a role in amino acid transpor in the kidney [review]

  7. the first human study of the gene TMEM27 and an attempt to shine a light on genotype-phenotype correlation in Turner syndrome patients.

  8. No TMEM27 gene mutations were discovered among 26 patients showing a phenotype resembling Dent's disease

Mouse (Murine) Transmembrane Protein 27 (TMEM27) interaction partners

  1. analysis of the interaction of amino acid transporters B0AT1 (show SLC6A19 Proteins) and B0AT3 with their ancillary protein collectrin

  2. Collectrin is a consequential link between the transport of l-arginine (show GATM Proteins) and endothelial nitric oxide synthase (show NOS3 Proteins) uncoupling in hypertension.

  3. Collectrin and ACE2 (show ACE2 Proteins) in renal and intestinal amino acid transport.

  4. transcriptional hierarchy between HNF-1beta (show HNF1B Proteins) and PKD (show PRKD1 Proteins) (polycystic kidney disease) genes expressed in the primary cilia of collecting duct cells has been suggested, and collectrin is one of such HNF-1beta (show HNF1B Proteins) regulated genes

  5. Tmem27 is a pancreatic beta cell transmembrane protein that regulates cell growth of pancreatic islets

  6. Our data suggest that collectrin is a novel mediator of renal amino acid transport and may provide further insight into the pathogenesis of a number of human disease correlates.

  7. data identify collectrin as a key regulator of renal amino acid uptake

  8. Collectrin has a role in amino acid transpor in the kidney [review]

  9. functional association of mutant B(0)AT1 (show SLC6A19 Proteins) transporters with ACE2 (show ACE2 Proteins) and collectrin in intestine and kidney, respectively, participates in the phenotypic heterogeneity of Hartnup disorder

  10. Collectrin-deficient mice activate a number of adaptive mechanisms to defend energy homeostasis in the setting of ongoing nutrient losses.

TMEM27 Protein Profile

Protein Summary

This gene encodes a transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells.

Gene names and symbols associated with TMEM27

  • transmembrane protein 27 (tmem27)
  • si:dkey-194e6.1 (si:dkey-194e6.1)
  • transmembrane protein 27 (TMEM27)
  • transmembrane protein 27 (Tmem27)
  • 0610008J07Rik protein
  • collectrin protein
  • MGC68634 protein
  • NX-17 protein
  • Nx17 protein
  • tmem27 protein

Protein level used designations for TMEM27

transmembrane protein 27 , kidney-specific membrane protein , collectrin

GENE ID SPECIES
379678 Xenopus laevis
402976 Danio rerio
418622 Gallus gallus
100144643 Xenopus (Silurana) tropicalis
57393 Homo sapiens
57394 Mus musculus
57395 Rattus norvegicus
513188 Bos taurus
611445 Canis lupus familiaris
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