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May be a survival factor for hippocampal and mesencephalic neurons. Additionally we are shipping TMEFF2 Proteins (8) and TMEFF2 Kits (1) and many more products for this protein.
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Human Monoclonal TMEFF2 Primary Antibody for EIA, IHC (p) - ABIN400860
Afar, Bhaskar, Ibsen, Breinberg, Henshall, Kench, Drobnjak, Powers, Wong, Evangelista, OHara, Powers, DuBridge, Caras, Winter, Anderson, Solvason, Stricker, Cordon-Cardo, Scher, Grygiel, Sutherland et al.: Preclinical validation of anti-TMEFF2-auristatin E-conjugated antibodies in the treatment of prostate cancer. ... in Molecular cancer therapeutics 2004
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Results suggest that TMEFF2 is a brain-enriched endogenous modulator of Abeta (show APP Antibodies) neurotoxicity and an enhancer of alpha-secretase processing of AbetaPP
TMEFF2 regulates the non-canonical activin (show Actbeta Antibodies)/BMP4 (show BMP4 Antibodies) signaling, PI3K (show PIK3CA Antibodies), and Ras/ERK1/2 (show MAPK1/3 Antibodies) pathways.
c-Myc (show MYC Antibodies) contributes to the epigenetic regulation of HPP1 (show NAE1 Antibodies) via the dominant recruitment of HDAC3 (show HDAC3 Antibodies).
TMEFF2 acts as a tumor suppressor in gastric cancer through direct interaction with SHP-1 and can be a potential biomarker of carcinogenesis.
TMEFF2 and SARDH (show SARDH Antibodies) cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells.
Androgen signaling promotes eIF2alpha (show EIF2A Antibodies) phosphorylation and subsequent translation of TMEFF2 via a mechanism that requires uORFs in the 5'-UTR (show UTS2R Antibodies) of TMEFF2.
Methylation of TMEFF2 gene is associated with colorectal neoplasia in ulcerative colitis and Crohn's colitis.
Findings suggest that methylation-associated down-regulation of TMEFF2 gene may be involved in lung tumorigenesis and TMEFF2 methylation can serve as a specific blood-based biomarker for NSCLC.
Several genes expressed at exceptionally high levels were identified associated with early oocyte development, TMEFF2, the Rho-GTPase-activating protein (show STARD13 Antibodies) oligophrenin 1 (OPHN1 (show OPHN1 Antibodies)) and the mitochondrial-encoded ATPase6 (ATP6 (show MT-ATP6 Antibodies)).
TMEFF2 can function to regulate PDGF (show PDGFA Antibodies) signaling; it is hypermethylated and downregulated in glioma and several other cancers
Loss of TMEFF2 is associated with cell migration and invasion leading to prostate cancer.
May be a survival factor for hippocampal and mesencephalic neurons. The shedded form may up-regulate cell proliferation (By similarity).
transmembrane protein with EGF-like and two follistatin-like domains 2
, cancer/testis antigen family 120, member 2
, hyperplastic polyposis protein 1
, transmembrane protein TENB2