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The protein encoded by TNPO3 is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. Additionally we are shipping Transportin 3 Proteins (3) and many more products for this protein.
Showing 10 out of 32 products:
Human Polyclonal TNPO3 Primary Antibody for ELISA, WB - ABIN1003308
Kataoka, Bachorik, Dreyfuss: Transportin-SR, a nuclear import receptor for SR proteins. in The Journal of cell biology 1999
Show all 3 references for ABIN1003308
Human Polyclonal TNPO3 Primary Antibody for EIA, WB - ABIN783568
Lai, Lin, Huang, Tsai, Tarn: A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins. in The Journal of biological chemistry 2000
Show all 2 references for ABIN783568
IRF5 (show IRF5 Antibodies)-TNPO3 genetic variation is associated systemic lupus erythematosus.
Data suggest that the HIV-1 integrase (IN)/transportin-SR2 (TRN-SR2) interaction interface is a potential target for antiviral therapy.
Tnpo3 mutants that are not able to interact with cleavage and polyadenylation specificity factor 6 (show CPSF6 Antibodies) do not facilitate HIV-1 infectivity, suggesting a potential route of pharmacological intervention in the treatment of AIDS.
In skeletal muscle of limb-girdle muscular dystrophy 1F individuals, expression of transportin 3 indicates altered transportin 3 function.
The TNPO3 gene is mapped within the Limb-girdle muscular dystrophy 1F critical interval and its 923-amino acid human gene product is also expressed in skeletal muscle.
a model wherein one monomer of TRN-SR2 is bound to one monomer of RanGTP.
These results suggested that inhibition of HIV-1 by TNPO3-depleted cells requires CPSF6 (show CPSF6 Antibodies).
TNPO3 promotes HIV-1 infectivity indirectly, by shifting the CA-binding protein CPSF6 (show CPSF6 Antibodies) to the nucleus, thus preventing the excessive HIV-1 CA stability that would otherwise result from cytoplasmic accumulation of CPSF6 (show CPSF6 Antibodies).
These results suggest that TNPO3 and cyclophilin A (show PPIA Antibodies) facilitate HIV-1 infection by coordinating proper uncoating of the core in target cells.
Identification of residues in the C-terminal domain of HIV-1 integrase that mediate binding to the transportin-SR2 protein.
The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Two transcript variants encoding different isoforms as well as a noncoding transcript have been found for this gene.
, transportin 3
, importin 12