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Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. Additionally we are shipping Trefoil Factor 2 Kits (45) and Trefoil Factor 2 Proteins (35) and many more products for this protein.
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Data show the important functions of TFF2 in the gastric mucus barrier, mucus epithelia, immune system, central nervous system, and during fertilization. It has been shown to interact with the gastric mucin MUC6 (show MUC6 Antibodies). [Review]
These findings suggest that the rs184432 and rs225359 polymorphisms in TFF1 (show TFF1 Antibodies) have protective effects for GC and contribute to the development of GC in Korean individuals.
We reproducibly associate higher expression of the ligand-receptor axis of TFF2 and CXCR4 (show CXCR4 Antibodies) with BRAF (show BRAF Antibodies) V600E-mutant colon cancer
protease-activated receptor 4 (show F2RL3 Antibodies) and Trefoil factor 2 are expressed in human colorectal cancer
The structural features of the N-linked N,N'-di-N-acetyllactosediamine-inducing determinant on human TFF2 are discussed.
Human TTF2 (show FOXE1 Antibodies) is a lectin that binds alpha-GlcNAc-capped mucin 6 (show MUC6 Antibodies) g with antibiotic activity against Helicobacter pylori.
Significantly higher levels of TFF2 were in patients with Multiple Organ Dysfunction Syndrome.
There is an association between TFF2 and TFF3 (show TFF3 Antibodies) polymorphisms and risk of atrophic gastritis and gastric cancer in Chinese people.
Human gastric TFF2 peptide contains an N-linked fucosylated N,N'-diacetyllactosediamine (LacdiNAc) oligosaccharide
this study indicated that Sp3 (show SP3 Antibodies) was a major regulator of TFF2 expression.
Low intestinal TFF2 expression was measured at early maturation stages. Weaning, however, was associated with a distinct response of increased TFF2 expression, indicating an important role in enhancing mucosal integrity.
Splenic TFF2 is released by vagally modulated memory T cells to suppress expansion of myeloid-derived suppressor cells (MDSC) through CXCR4 (show CXCR4 Antibodies). TFF2 is important to the anti-inflammatory reflex arc (show NOL3 Antibodies) and has an essential role in arresting MDSC proliferation.
hnRNP A1 (show HNRNPA1 Antibodies) improves intestinal injury in anti-CD3 (show CD3E Antibodies) antibody-induced enteritis mice through the upregulation of TFF2, which regulates apoptosis and enhances epithelial restoration
Overexpressing Tff2 in cultured cells reduced doubling time in vitro and rapidly increased xenograft tumor size in vivo
Epithelial TFF2 is an important endogenous regulator of gut (show GUSB Antibodies) mucosal homeostasis that can modulate immune and epithelial compartments.
The Tff2 gene is expressed in the hypothalamus and is regulated by food intake. Knockout mice are leaner (show CACNA1A Antibodies) and have reduced fat mass compared to wild-type.
The increased expression of endogenous TFF2 in response to chronic allergic inflammation is insufficient to prevent the progression of airway inflammation and remodeling in a model of chronic allergic airways disease.
TFF2 functions as a regulator of intestinal homeostasis that suppresses Toxoplasma gondii-driven type 1 inflammation.
TFF2 (trefoil factor 2), an epithelial cell-derived repair molecule, is needed for the control of lung injury caused by the hookworm parasite Nippostrongylus brasiliensis and for type 2 immunity after infection.
results suggest that during retinal cell death periods, requiring a tightly regulated balance between cell survival and cell death, TFF2 acts pro-proliferative and pro-apoptotic at least in developing mouse retinae cultured in vivo
functional NHE2 (show SLC9A2 Antibodies), but not NHE1 (show SLC9A1 Antibodies), is essential for mouse gastric epithelial restitution and TFFs activate epithelial repair via NHE2 (show SLC9A2 Antibodies)
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.
trefoil factor 2
, trefoil factor 2 (spasmolytic protein 1)
, trefoil factor family peptide 2
, spasmolytic polypeptide
, spasmolytic protein 1
, pancreatic spasmolytic polypeptide
, spasmolytic peptide
, spasmolytic peptide 1
, spasmolytic polypeptide 1
, P-domain peptide
, TFF p4.1
, putative gastrointestinal growth factor xP4