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TRIB2 encodes one of three members of the Tribbles family. Additionally we are shipping Tribbles Homolog 2 (Drosophila) Proteins (12) and many more products for this protein.
Showing 10 out of 65 products:
Human Monoclonal TRIB2 Primary Antibody for IHC (p), RNAi - ABIN565396
Wang, Zhang, Weng, Qiao, Ma, Xiao, Yu, Pan, Sun et al.: Impaired phosphorylation and ubiquitination by p70 S6 kinase (p70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promote tribbles homolog 2 (TRIB2) stability and carcinogenic property in ... in The Journal of biological chemistry 2013
Show all 3 references for ABIN565396
Chicken Polyclonal TRIB2 Primary Antibody for WB - ABIN2786174
Lin, Lee, Hung, Li, Yang-Yen, Yen: Survival factor withdrawal-induced apoptosis of TF-1 cells involves a TRB2-Mcl-1 axis-dependent pathway. in The Journal of biological chemistry 2007
tissues expressing the highest levels of Xtrb2 were most markedly affected by morpholino knockdown, with perturbation of neural crest and eye development
High TRIB2 reinforces the oncogenic transcriptional program controlled by the TAL1 (show TAL1 Antibodies) complex in T-cell acute lymphoblastic leukemia.
Studies suggest that pseudo-kinase family of tribbles (show TRIB1 Antibodies) (TRIB) proteins TRIB1 (show TRIB1 Antibodies), TRIB2 and TRIB3 (show TRIB3 Antibodies) play roles in pathogenesis of rheumatoid arthritis (RA) and osteoarthritis.
Studies suggest that pseudo-kinase family of tribbles (show TRIB1 Antibodies) (TRIB) proteins TRIB1 (show TRIB1 Antibodies), TRIB2 and TRIB3 (show TRIB3 Antibodies) were involved in the pathogenesis of inflammation.
Studies suggest that tribbles homolog 2 (Drosophila) protein (TRIB2) as a meaningful biomarker to both diagnose and stage melanoma.
Studies indicate that the molecular interactions that take place between tribbles homolog 2 (Drosophila) protein (TRIB2) and factors involved in the ubiquitin proteasome system (UPS) are varied and have differential downstream effects.
Studies indicate that small molecules can reveal rate-limiting signalling outputs and functions of pseudo-kinase family of tribbles (show TRIB1 Antibodies) (TRIB) proteins TRIB1 (show TRIB1 Antibodies), TRIB2 and TRIB3 (show TRIB3 Antibodies) in cells and intact organisms, serving as guides for the development of new drugs.
Studies show that TRIB1 (show TRIB1 Antibodies) and TRIB2 are highly expressed in molecularly-defined sub-types of acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)).
Studies show a remarkable reduction in tribbles (show TRIB1 Antibodies) 2 protein (Trib2) expression during oocyte maturation whereas tribbles (show TRIB1 Antibodies) 1 protein (Trib1 (show TRIB1 Antibodies)) and tribbles 3 (show TRIB3 Antibodies) protein (Trib3 (show TRIB3 Antibodies)) expression was significantly increased during this process.
The results suggest that TRIB2 is a meaningful biomarker reflecting diagnosis and progression of melanoma, as well as predicting clinical response to chemotherapy.
Data suggest that TRB2 exhibits metal-independent autophosphorylation activity, low affinity ATP binding/hydrolysis, and a conserved catalytic lysine residue in the active site (rather than the asparagine in many metal-dependent kinases).
TRIB1 (show TRIB1 Antibodies) and TRIB3 (show TRIB3 Antibodies) are more strongly expressed than TRIB2 in cumulus cells (CC) surrounding oocytes from preovulatory follicles than in CC of immature ones.
we identify the contribution of dysregulated C/EBPalpha (show CEBPA Antibodies) and E2F1 (show E2F1 Antibodies) to elevated Trib2 expression and leukemic cell survival
Trib2 transduced hematopoietic stem cells developed acute myeloid leukemia (show BCL11A Antibodies).
Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients.
Data identify Tribbles homolog 2 as an oncogene (show RAB1A Antibodies) that induces acute myelogenous leukemia through a mechanism involving inactivation of C/EBPalpha (show CEBPA Antibodies).
describe suppression of adipocyte differentiation by TRBs Trib1 (show TRIB1 Antibodies), Trib2, Trib3 (show TRIB3 Antibodies)
Mice reconstituted with HSC (show FUT1 Antibodies) cotransduced with HoxA9 (show HOXA9 Antibodies) and Trib2 had accelerated onset of AML (show RUNX1 Antibodies) compared to either gene alone
Linkage of Meis1 (show MEIS1 Antibodies) leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3 (show CCL3 Antibodies).
These results suggest that Trb2 plays minimal roles during kidney and mouse development.
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
tribbles homolog 2 (Drosophila)
, tribbles homolog 2-like
, tribbles homolog 2
, serine/threonine protein kinase
, tribbles-like protein 2