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TRIB2 encodes one of three members of the Tribbles family. Additionally we are shipping Tribbles Homolog 2 (Drosophila) Antibodies (68) and Tribbles Homolog 2 (Drosophila) Proteins (12) and many more products for this protein.
tissues expressing the highest levels of Xtrb2 were most markedly affected by morpholino knockdown, with perturbation of neural crest and eye development
O-GlcNAcylation of TRIB2 might be critical for diabetes-associated liver cancer.
Tumors from resistant patients expressed the lowest levels of TRIB2. Downregulation of TRIB2 contributes to platin-resistance.
our data show that excess p30 (show CENPV ELISA Kits) cooperated with TRIB2 only in the presence of p42 (show EPB42 ELISA Kits) to accelerate acute myeloid leukaemia (AML (show RUNX1 ELISA Kits)), and the direct interaction and degradation of C/EBPa (show CEBPA ELISA Kits) p42 (show EPB42 ELISA Kits) is required for TRIB2-mediated AML (show RUNX1 ELISA Kits).
miR (show MLXIP ELISA Kits)-206 and miR (show MLXIP ELISA Kits)-140, as tumor suppressors, induced lung adenocarcinoma cell death and inhibited cell proliferation by modifying oncogenic TRIB2 promoter activity through p-Smad3 (show SMAD3 ELISA Kits).
Studied effect of TRIB2 SNP on the expression of genes involved in adaptive thermogenesis using messenger RNAs prepared from adipose tissues of Japanese adults. Of the five thermogenic genes, DIO2 (show DIO2 ELISA Kits), CIDEA (show CIDEA ELISA Kits), PPARGC1A (show PPARGC1A ELISA Kits), and PRDM16 (show PRDM16 ELISA Kits) showed significantly higher transcript levels in SAT of individuals with the AA genotype relative to those with the AT + TT genotype.
Data show that TRIB2-mediated degradation of CDC25C (show CDC25C ELISA Kits) is associated with lysine-48-linked CDC25C (show CDC25C ELISA Kits) polyubiquitination driven by the TRIB2 kinase-like domain.
High TRIB2 reinforces the oncogenic transcriptional program controlled by the TAL1 (show TAL1 ELISA Kits) complex in T-cell acute lymphoblastic leukemia.
Studies suggest that pseudo-kinase family of tribbles (show TRIB1 ELISA Kits) (TRIB) proteins TRIB1 (show TRIB1 ELISA Kits), TRIB2 and TRIB3 (show TRIB3 ELISA Kits) play roles in pathogenesis of rheumatoid arthritis (RA) and osteoarthritis.
Studies suggest that pseudo-kinase family of tribbles (show TRIB1 ELISA Kits) (TRIB) proteins TRIB1 (show TRIB1 ELISA Kits), TRIB2 and TRIB3 (show TRIB3 ELISA Kits) were involved in the pathogenesis of inflammation.
Studies suggest that tribbles homolog 2 (Drosophila) protein (TRIB2) as a meaningful biomarker to both diagnose and stage melanoma.
The absence of a change in hypocretin (show OX ELISA Kits) cell populations suggested that factors other than anti-TRIB2 antibody play a part in the loss of hypocretin (show OX ELISA Kits) neurons in narcolepsy. The increased anti-TRIB2 antibody after the destruction of hypocretin (show OX ELISA Kits) neurons suggest that anti-TRIB2 antibody in narcolepsy patients is the consequence rather than the inciting cause of hypocretin (show OX ELISA Kits) cell destruction.
These data indicate that Trib2 has a complex role in the pathogenesis of Notch (show NOTCH1 ELISA Kits)-driven T-ALL, which may vary between different T-ALL subtypes.
TRIB1 (show TRIB1 ELISA Kits) and TRIB3 (show TRIB3 ELISA Kits) are more strongly expressed than TRIB2 in cumulus cells (CC) surrounding oocytes from preovulatory follicles than in CC of immature ones.
we identify the contribution of dysregulated C/EBPalpha (show CEBPA ELISA Kits) and E2F1 (show E2F1 ELISA Kits) to elevated Trib2 expression and leukemic cell survival
Trib2 transduced hematopoietic stem cells developed acute myeloid leukemia (show BCL11A ELISA Kits).
Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients.
Data identify Tribbles homolog 2 as an oncogene (show RAB1A ELISA Kits) that induces acute myelogenous leukemia through a mechanism involving inactivation of C/EBPalpha (show CEBPA ELISA Kits).
describe suppression of adipocyte differentiation by TRBs Trib1 (show TRIB1 ELISA Kits), Trib2, Trib3 (show TRIB3 ELISA Kits)
Mice reconstituted with HSC (show FUT1 ELISA Kits) cotransduced with HoxA9 (show HOXA9 ELISA Kits) and Trib2 had accelerated onset of AML (show RUNX1 ELISA Kits) compared to either gene alone
Linkage of Meis1 (show MEIS1 ELISA Kits) leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3 (show CCL3 ELISA Kits).
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
tribbles homolog 2 (Drosophila)
, tribbles homolog 2-like
, tribbles homolog 2
, serine/threonine protein kinase
, tribbles-like protein 2