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anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) Antibodies

TREM2 encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. Additionally we are shipping TREM2 Kits (18) and TREM2 Proteins (13) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TREM2 54209 Q9NZC2
TREM2 83433 Q99NH8
TREM2 301227  
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Top anti-TREM2 Antibodies at antibodies-online.com

Showing 10 out of 176 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Goat Un-conjugated EIA, WB Sstaining of Mouse Liver lysate using Anti-TREM2 antibody at 0.3 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated EIA, WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Goat Un-conjugated IHC (p) 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rat Un-conjugated FACS Detection of TREM-2 in THP-1 Human Cell Line by Flow Cytometry. THP-1 human acute monocytic leukemia cell line was stained with Rat Anti-Human/Mouse TREM-2 Monoclonal Antibody. Detection of TREM-2 in Human Mature Dendritic Cells by Flow Cytometry. Human mature dendritic cells were stained with Rat Anti-Human/Mouse TREM-2 Monoclonal Antibody. 100 μg Log in to see 8 to 9 Days
$294.00
Details
Human Mouse Un-conjugated ELISA, SimWes, WB Simple Western: TREM-2 Antibody (2B5) [NBP1-07101] - Simple Western lane view shows a specific band for TREM-2 in 0.5 mg/ml of MCF-7 lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. Western Blot: TREM-2 Antibody (2B5) [NBP1-07101] - Cell lysates of HeLa, MCF7, LNCaP and mouse brain (30ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human TREM2 (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated FACS, IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human gastritis labeled with Anti-TREM2 Polyclonal Antibody, unconjugated (ABIN749678)  at 1: 200 followed by incubation with conjugated secondary antibody and DAB staining Human colon carcinoma lysate 30ug, probed (ABIN749678) at 1:200 overnight in 4 °C. Followed by conjugation to the secondary antibody at 1:3000 90min in 37 °C. Predicted band size at 25 kDa, and observed band size at 30kDa. 100 μL Log in to see 3 to 7 Days
$307.45
Details
Human Goat Un-conjugated FACS, ICC, WB TREM-2 in Human Dendritic Cells. TREM-2 was detected in immersion fixed immature human dendritic cells using Goat Anti-Human TREM-2 Antigen Affinity-purified Polyclonal Antibody. Specific staining was localized to cytoplasm. Detection of Human TREM-2 by Western Blot. Western blot shows lysates of THP-1 human acute monocytic leukemia cell line. PVDF membrane was probed with 0.2 ug/mL of Goat Anti-Human TREM-2 Antigen Affinity-purified Polyclonal Antibody. This experiment was conducted under reducing conditions. 100 μg Log in to see 8 to 9 Days
$378.00
Details
Mouse Rat Un-conjugated EIA, IP   0.1 mg Log in to see 6 to 8 Days
$423.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details

TREM2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-TREM2 Antibodies

  1. Human Monoclonal TREM2 Primary Antibody for FACS - ABIN4900550 : Wu, Byers, Jin, Agapov, Alexander-Brett, Patel, Cella, Gilfilan, Colonna, Kober, Brett, Holtzman: TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. in The Journal of experimental medicine 2015 (PubMed)
    Show all 2 references for ABIN4900550

  2. Human Monoclonal TREM2 Primary Antibody for ELISA, SimWes - ABIN449602 : Roussos, Katsel, Fam, Tan, Purohit, Haroutunian: The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia. in Alzheimer's & dementia : the journal of the Alzheimer's Association 2015 (PubMed)
    Show all 2 references for ABIN449602

  3. Human Monoclonal TREM2 Primary Antibody for EIA, WB - ABIN336080 : NDiaye, Branda, Branda, Nevarez, Colonna, Lowell, Hamerman, Seaman: TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. in The Journal of cell biology 2009 (PubMed)
    Show all 2 references for ABIN336080

  4. Mouse (Murine) Monoclonal TREM2 Primary Antibody for EIA, IP - ABIN1109326 : Koga, Inui, Inoue, Kim, Suematsu, Kobayashi, Iwata, Ohnishi, Matozaki, Kodama, Taniguchi, Takayanagi, Takai: Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. in Nature 2004 (PubMed)

  5. Human Polyclonal TREM2 Primary Antibody for FACS, IF (p) - ABIN749678 : Satoh, Kawana, Yamamoto, Ishida, Saito, Arima: A survey of TREM2 antibodies reveals neuronal but not microglial staining in formalin-fixed paraffin-embedded postmortem Alzheimer's brain tissues. in Alzheimer's research & therapy 2014 (PubMed)

  6. Mouse (Murine) Polyclonal TREM2 Primary Antibody for EIA, WB - ABIN615905 : Takahashi, Prinz, Stagi, Chechneva, Neumann: TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis. in PLoS medicine 2007 (PubMed)

More Antibodies against TREM2 Interaction Partners

Human Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. silencing TREM-2 downregulated the expression levels of Bcl2 (show BCL2 Antibodies) and PCNA (show PCNA Antibodies), and upregulated the expression levels of Bax (show BAX Antibodies) and caspase-3 (show CASP3 Antibodies) in renal cell carcinoma (show MOK Antibodies) cells. Depletion of TREM-2 inactivated PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway through increasing the expression of PTEN (show PTEN Antibodies). TREM-2 acts as an oncogene (show RAB1A Antibodies) in the development of renal cell carcinoma (show MOK Antibodies) and can be considered as a novel therapeutic factor in the treatment of renal cell carcinoma (show MOK Antibodies).

  2. TREM2 expression is significantly upregulated in human masticatory mucosa during wound healing

  3. this study shows that activation of TREM-2 may restrain h-MSC (show MSC Antibodies) immune activation and promote differentiation for tissue repair

  4. The TREM family members are also considered to involve in Alzheimer's disease (AD) and cerebrospinal fluid (CSF (show CSF2 Antibodies)) soluble form of TREM2 (sTREM2) levels has also been associated with respond to progression of disease.

  5. Study provides evidence that TREM2 mRNA is upregulated in the human hippocampus affected by Alzheimer's disease (AD). Findings also suggest that 5hmC may play a role in regulating TREM2 mRNA expression in AD hippocampus.

  6. The study suggests that TREM2 may work as an oncogene (show RAB1A Antibodies) and a new effective therapeutic target for glioma treatment.

  7. CSF (show CSF2 Antibodies) concentrations of soluble TREM2 are higher in Alzheimer's disease than in controls

  8. Variant p.R47H of TREM2 was not associated with Parkinson's disease

  9. Our results corroborate and extend previous findings, concluding that the variant rs75932628-T (p.R47H) in TREM2 is not a risk factor for leucoaraiosis or Parkinson's disease in the Han Chinese population.

  10. the minor T allele at TREM2 (p.R47H, rs75932628) showed nominally significant association with AD risk (OR 5 5.73, 95% CI 5 1.80-18.25, P 5 .0232), whereas no significant association for risk of frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS), and Parkinson's disease.

Mouse (Murine) Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. This study showed that TREM-2 deficiency restricts the inflammatory response, thereby decreasing organ damage and mortality.

  2. TREM2 attenuates tau kinase activity through restriction of neuroinflammation, and thus protects against tau pathology.

  3. TREM2 is involved in prion (show PRNP Antibodies)-induced microglial activation but does not noticeably modulate the pathogenesis of experimental prion (show PRNP Antibodies) infections.

  4. These findings provide a novel interpretation of Brucella intracellular growth through inhibition of NO production produced by TREM-2-mediated activated macrophages.

  5. TREM-1 (show TREM1 Antibodies)/TREM-3 macrophage expression improved host defense against Klebsiella-derived pneumosepsis, whereas TREM-2 did not have a role.

  6. These findings place TREM2 as a key regulator of microglia activation in vivo in response to tissue damage

  7. TREM-2 has a protective effect on inflammatory response of endotoxin-induced acute lung injury in mice.

  8. results support a role of DAP12 (show TYROBP Antibodies) in stabilizing TREM2-CTF (show NFIA Antibodies), thereby protecting against excessive pro-inflammatory responses.

  9. Corpus callosum microglia normally expand with age, but aged Trem2(-/-) mice had fewer microglia with an abnormal morphology which failed to amplify transcripts indicative of activation, phagocytosis, and lipid catabolism in response to myelin damage.

  10. Data (including data from studies using knockout mice) suggest that TREM2 is expressed on alveolar macrophages and lung mucosa and plays role innate immunity during pneumococcal pneumonia; knockout of TREM2 increases phagocytosis and survival.

TREM2 Antigen Profile

Protein Summary

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with TREM2

  • triggering receptor expressed on myeloid cells 2 (TREM2) antibody
  • triggering receptor expressed on myeloid cells 2 (trem2) antibody
  • triggering receptor expressed on myeloid cells 2 (LOC100228399) antibody
  • triggering receptor expressed on myeloid cells 2 (Trem2) antibody
  • TREM-2 antibody
  • TREM-A1 antibody
  • TREM-B1 antibody
  • TREM2 antibody
  • Trem2a antibody
  • Trem2b antibody
  • Trem2c antibody

Protein level used designations for TREM2

triggering receptor expressed on myeloid cells 2 , triggering receptor expressed on monocytes 2 , triggering receptor expressed on myeloid cells 2a , triggering receptor expressed on myeloid cells 2b , triggering receptor expressed on myeloid cells 2c

GENE ID SPECIES
419920 Gallus gallus
748470 Pan troglodytes
100126214 Xenopus (Silurana) tropicalis
100228399 Taeniopygia guttata
719740 Macaca mulatta
54209 Homo sapiens
83433 Mus musculus
301227 Rattus norvegicus
608965 Canis lupus familiaris
100737974 Sus scrofa
506467 Bos taurus
Selected quality suppliers for anti-TREM2 (TREM2) Antibodies
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