anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) Antibodies

TREM2 encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. Additionally we are shipping TREM2 Kits (24) and TREM2 Proteins (14) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TREM2 54209 Q9NZC2
TREM2 83433 Q99NH8
TREM2 301227  
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Top anti-TREM2 Antibodies at antibodies-online.com

Showing 10 out of 192 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Goat Un-conjugated EIA, WB Sstaining of Mouse Liver lysate using Anti-TREM2 antibody at 0.3 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated EIA, WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Rabbit Un-conjugated FACS, IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human gastritis labeled with Anti-TREM2 Polyclonal Antibody, unconjugated (ABIN749678)  at 1: 200 followed by incubation with conjugated secondary antibody and DAB staining Human colon carcinoma lysate 30ug, probed (ABIN749678) at 1:200 overnight in 4 °C. Followed by conjugation to the secondary antibody at 1:3000 90min in 37 °C. Predicted band size at 25 kDa, and observed band size at 30kDa. 100 μL Log in to see 3 to 7 Days
$307.45
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rat Un-conjugated FACS Detection of TREM-2 in THP-1 Human Cell Line by Flow Cytometry. THP-1 human acute monocytic leukemia cell line was stained with Rat Anti-Human/Mouse TREM-2 Monoclonal Antibody. Detection of TREM-2 in Human Mature Dendritic Cells by Flow Cytometry. Human mature dendritic cells were stained with Rat Anti-Human/Mouse TREM-2 Monoclonal Antibody. 100 μg Log in to see 8 to 9 Days
$294.00
Details
Human Mouse Un-conjugated ELISA, SimWes, WB Simple Western: TREM-2 Antibody (2B5) [NBP1-07101] - Simple Western lane view shows a specific band for TREM-2 in 0.5 mg/ml of MCF-7 lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. Western Blot: TREM-2 Antibody (2B5) [NBP1-07101] - Cell lysates of HeLa, MCF7, LNCaP and mouse brain (30ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human TREM2 (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Goat Un-conjugated FACS, ICC, WB TREM-2 in Human Dendritic Cells. TREM-2 was detected in immersion fixed immature human dendritic cells using Goat Anti-Human TREM-2 Antigen Affinity-purified Polyclonal Antibody. Specific staining was localized to cytoplasm. Detection of Human TREM-2 by Western Blot. Western blot shows lysates of THP-1 human acute monocytic leukemia cell line. PVDF membrane was probed with 0.2 ug/mL of Goat Anti-Human TREM-2 Antigen Affinity-purified Polyclonal Antibody. This experiment was conducted under reducing conditions. 100 μg Log in to see 8 to 9 Days
$378.00
Details
Mouse Rat Un-conjugated EIA, IP   0.1 mg Log in to see 6 to 8 Days
$423.50
Details
Human Goat Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Goat Un-conjugated IHC, ELISA, WB   100 μg Log in to see 6 to 7 Days
$326.89
Details

TREM2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-TREM2 Antibodies

  1. Human Polyclonal TREM2 Primary Antibody for FACS, ICC - ABIN4899382 : Quan, Cooper, Potter, Roberts, Cheng, Jarvis: TREM-2 binds to lipooligosaccharides of Neisseria gonorrhoeae and is expressed on reproductive tract epithelial cells. in Mucosal immunology 2008 (PubMed)
    Show all 3 references for 4899382

  2. Human Monoclonal TREM2 Primary Antibody for ELISA, SimWes - ABIN449602 : Roussos, Katsel, Fam, Tan, Purohit, Haroutunian: The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia. in Alzheimer's & dementia : the journal of the Alzheimer's Association 2015 (PubMed)
    Show all 2 references for 449602

  3. Human Monoclonal TREM2 Primary Antibody for FACS - ABIN4900550 : Wu, Byers, Jin, Agapov, Alexander-Brett, Patel, Cella, Gilfilan, Colonna, Kober, Brett, Holtzman: TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. in The Journal of experimental medicine 2015 (PubMed)
    Show all 2 references for 4900550

  4. Human Monoclonal TREM2 Primary Antibody for EIA, WB - ABIN336080 : NDiaye, Branda, Branda, Nevarez, Colonna, Lowell, Hamerman, Seaman: TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. in The Journal of cell biology 2009 (PubMed)
    Show all 2 references for 336080

  5. Mouse (Murine) Monoclonal TREM2 Primary Antibody for EIA, IP - ABIN1109326 : Koga, Inui, Inoue, Kim, Suematsu, Kobayashi, Iwata, Ohnishi, Matozaki, Kodama, Taniguchi, Takayanagi, Takai: Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. in Nature 2004 (PubMed)

  6. Mouse (Murine) Polyclonal TREM2 Primary Antibody for EIA, WB - ABIN615905 : Takahashi, Prinz, Stagi, Chechneva, Neumann: TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis. in PLoS medicine 2007 (PubMed)

  7. Human Polyclonal TREM2 Primary Antibody for FACS, IF (p) - ABIN749678 : Satoh, Kawana, Yamamoto, Ishida, Saito, Arima: A survey of TREM2 antibodies reveals neuronal but not microglial staining in formalin-fixed paraffin-embedded postmortem Alzheimer's brain tissues. in Alzheimer's research & therapy 2014 (PubMed)

More Antibodies against TREM2 Interaction Partners

Human Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. SNPs involved in pathways related to virus cellular entry and vesicular trafficking were overrepresented, suggesting that cerebrospinal fluid soluble TREM2 levels could be an informative phenotype for Alzheimer disease

  2. Rare coding variants of TREM2 may play an important role in AD in Han Chinese.

  3. These data demonstrate that cerebrospinal fluid soluble TREM2 levels are increased in the early symptomatic phase of Alzheimer's disease, probably reflecting a corresponding change of the microglia activation status in response to neuronal degeneration.

  4. link three genetic risk factors for Alzheimer's disease and reveal a possible mechanism by which mutant TREM2 increases risk of AD

  5. Microglia in Alzheimer's disease (AD) patients carrying TREM2 risk variants and TREM2-deficient mice with AD-like pathology have abundant autophagic vesicles, as do TREM2-deficient macrophages under growth-factor limitation or endoplasmic reticulum (ER) stress. Study concludes that TREM2 enables microglial responses during AD by sustaining cellular energetic and biosynthetic metabolism.

  6. TREM2 deficiency may disrupt the formation of a neuroprotective microglia barrier that regulates amyloid compaction and insulation

  7. flow cytometry analyses indicated significantly lower surface expression of T66M TREM2 variant than wild type or other TREM2 variants

  8. silencing TREM-2 downregulated the expression levels of Bcl2 (show BCL2 Antibodies) and PCNA (show PCNA Antibodies), and upregulated the expression levels of Bax (show BAX Antibodies) and caspase-3 (show CASP3 Antibodies) in renal cell carcinoma (show MOK Antibodies) cells. Depletion of TREM-2 inactivated PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway through increasing the expression of PTEN (show PTEN Antibodies). TREM-2 acts as an oncogene (show RAB1A Antibodies) in the development of renal cell carcinoma (show MOK Antibodies) and can be considered as a novel therapeutic factor in the treatment of renal cell carcinoma (show MOK Antibodies).

  9. TREM2 expression is significantly upregulated in human masticatory mucosa during wound healing

  10. this study shows that activation of TREM-2 may restrain h-MSC (show MSC Antibodies) immune activation and promote differentiation for tissue repair

Mouse (Murine) Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. TREM2 and TREML2 (show TREML2 Antibodies) play opposite roles in microglia activation.

  2. Our study suggests that Vps35 (show vps35 Antibodies)/retromer is responsible for recycling of Trem2 in the regulation of microglial function such as proinflammatory responses, whereas R47H mutation impairs Trem2 trafficking, which might contribute to Alzheimer disease.

  3. Microglia in Alzheimer's disease (AD) patients carrying TREM2 risk variants and TREM2-deficient mice with AD-like pathology have abundant autophagic vesicles, as do TREM2-deficient macrophages under growth-factor limitation or endoplasmic reticulum (ER) stress. Study concludes that TREM2 enables microglial responses during AD by sustaining cellular energetic and biosynthetic metabolism.

  4. This study demonstrate a critical role of TREM2-mediated Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway in microglial viability and suggest that modulating this pathway therapeutically may help to combat the impaired microglial survival.

  5. Triggering receptor expressed on myeloid cells 2 (TREM2) is an immunoglobulin-like receptor of the TREM family and is expressed on activated macrophages, immature dendritic cells, osteoclasts, and microglia.

  6. TREM2 deficiency may disrupt the formation of a neuroprotective microglia barrier that regulates amyloid compaction and insulation

  7. TREM2 deficiency has opposing effects on Alzheimer's disease-related pathologies at early and late stages of disease progression.

  8. TREM2 protects from Alzheimer's disease by enabling microglia to surround and alter Abeta (show APP Antibodies) plaque structure, thereby limiting neuritic damage.

  9. Recent studies have revealed that activated microglia in the spinal dorsal horn exacerbate neuropathic pain, which has suggested that suppression of microglial activity should be considered as a therapeutic target. However, only a few molecules have been identified as regulators of microglial activity. In this study, we focused on a receptor complex of TREM2 and DAP12 (show TYROBP Antibodies), both of which are expressed by microglia and have bee

  10. The authors demonstrate that a TREM2 loss-of-function mutation causes brain-wide metabolic alterations pointing toward a possible function of microglia in regulating brain glucose metabolism.

TREM2 Antigen Profile

Protein Summary

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with TREM2

  • triggering receptor expressed on myeloid cells 2 (TREM2) antibody
  • triggering receptor expressed on myeloid cells 2 (trem2) antibody
  • triggering receptor expressed on myeloid cells 2 (LOC100228399) antibody
  • triggering receptor expressed on myeloid cells 2 (Trem2) antibody
  • TREM-2 antibody
  • TREM-A1 antibody
  • TREM-B1 antibody
  • TREM2 antibody
  • Trem2a antibody
  • Trem2b antibody
  • Trem2c antibody

Protein level used designations for TREM2

triggering receptor expressed on myeloid cells 2 , triggering receptor expressed on monocytes 2 , triggering receptor expressed on myeloid cells 2a , triggering receptor expressed on myeloid cells 2b , triggering receptor expressed on myeloid cells 2c

GENE ID SPECIES
419920 Gallus gallus
748470 Pan troglodytes
100126214 Xenopus (Silurana) tropicalis
100228399 Taeniopygia guttata
719740 Macaca mulatta
54209 Homo sapiens
83433 Mus musculus
301227 Rattus norvegicus
608965 Canis lupus familiaris
100737974 Sus scrofa
506467 Bos taurus
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