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TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008].. Additionally we are shipping TREML2 Kits (19) and TREML2 Proteins (8) and many more products for this protein.
Showing 10 out of 33 products:
Human Monoclonal TREML2 Primary Antibody for IP - ABIN2662890
Ford, McVicar: TREM and TREM-like receptors in inflammation and disease. in Current opinion in immunology 2009
Show all 5 references for ABIN2662890
Human Monoclonal TREML2 Primary Antibody for FACS - ABIN2662891
Hashiguchi, Kobori, Ritprajak, Kamimura, Kozono, Azuma: Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses. in Proceedings of the National Academy of Sciences of the United States of America 2008
Show all 5 references for ABIN2662891
Mouse (Murine) Monoclonal TREML2 Primary Antibody for FACS - ABIN2663936
Leitner, Klauser, Pickl, Stöckl, Majdic, Bardet, Kreil, Dong, Yamazaki, Zlabinger, Pfistershammer, Steinberger: B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction. in European journal of immunology 2009
Show all 4 references for ABIN2663936
Human Polyclonal TREML2 Primary Antibody for ELISA - ABIN1999043
Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: The DNA sequence and analysis of human chromosome 6. ... in Nature 2003
Show all 4 references for ABIN1999043
Human Polyclonal TREML2 Primary Antibody for WB - ABIN2783949
King, Herrin, Justement: Trem-like transcript 2 is expressed on cells of the myeloid/granuloid and B lymphoid lineage and is up-regulated in response to inflammation. in Journal of immunology (Baltimore, Md. : 1950) 2006
Missense variant in TREML2 protects against Alzheimer's disease.
TLT2 may be involved in the innate immune response based on its expression profile and the fact that it is up-regulated in response to inflammation.
analysis of an interaction between B7-H3 (show CD276 Antibodies) and TLT-2 that preferentially enhances CD8 (show CD8A Antibodies)(+) T cell activation
Data do not point to a role for TREML2 as a receptor for B7-H3 (show CD276 Antibodies).
Thus, our studies identified TLT2 as an engulfment receptor for apoptotic cells.
TLT2 ligation enhances the neutrophil response to the formylated peptide FMLF, leading to increased reactive oxygen species production, degranulation, and chemotaxis
(+) T-cell effector function, possibly by ligation of TLT-2 on tumour-infiltrating CD8 (show CD8A Antibodies)(+) T cells at the local tumour site.
TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003
triggering receptor expressed on myeloid cells-like 2
, triggering receptor expressed on myeloid cells
, trem-like transcript 2 protein
, triggering receptor expressed on myeloid cells-like protein 2
, triggering receptor expressed on myeloid cells-like 2a dominant