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anti-Trimethylguanosine Synthase 1 (TGS1) Antibodies

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. Additionally we are shipping TGS1 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TGS1 72568 Q8C735
TGS1 96764 Q96RS0
TGS1 312947 P85107
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Top anti-TGS1 Antibodies at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-TGS1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged NCOA6IP is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 8 to 10 Days
$419.83
Details
Human Rabbit Un-conjugated WB TGS1 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 14 Days
$369.79
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged NCOA6IP is approximately 0.3ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 14 Days
$527.15
Details
Human Rabbit Un-conjugated IP, ELISA, WB   20 μg Log in to see 8 to 10 Days
$815.83
Details
Human Rabbit Un-conjugated ELISA, WB   50 μL Log in to see 9 to 11 Days
$313.50
Details

TGS1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine)


Human , ,
,
,
Rat (Rattus)


Top referenced anti-TGS1 Antibodies

  1. Chicken Polyclonal TGS1 Primary Antibody for WB - ABIN2783564 : Fanélus, Desrosiers: Reactive oxygen species generated by thiol-modifying phenylarsine oxide stimulate the expression of protein L-isoaspartyl methyltransferase. in Biochemical and biophysical research communications 2008 (PubMed)

More Antibodies against TGS1 Interaction Partners

Mouse (Murine) Trimethylguanosine Synthase 1 (TGS1) interaction partners

  1. LIN9 (show LIN9 Antibodies) is essential for proliferation and genome stability of ESCs (show NR2E3 Antibodies) by activating genes with important functions in mitosis and cytokinesis

  2. PIMT (show PCMT1 Antibodies) is expressed in all cells of the E3.5day blastocyst in the mouse.

  3. inactivation of LIN9 (show LIN9 Antibodies), a subunit of DREAM, results in premature senescence, which can be overcome by the SV40 large T (LT) antigen

  4. These experiments provide the first direct genetic evidence for the role of LIN9 (show LIN9 Antibodies) in development and mitotic gene regulation and they suggest that it may function as a haploinsufficient tumor suppressor.

  5. there is a feedback mechanism between ARF (show CDKN2A Antibodies) and Mip130/LIN-9 (show LIN9 Antibodies) in which either the increase of ARF (show CDKN2A Antibodies) or the decrease in Mip130/LIN-9 (show LIN9 Antibodies)

  6. Mutation of BARA/LIN-9 (show LIN9 Antibodies) restores the expression of E2F (show E2F1 Antibodies) target genes in CDK4 (show CDK4 Antibodies) null Mouse Embryo Fibroblasts, indicating that the wild-type protein plays a role in the expression of genes required for the G1/S transition.

  7. Mip (show MIP Antibodies)/LIN-9 (show LIN9 Antibodies) is required for the expression of B-Myb (show MYBL2 Antibodies), and both proteins collaborate in the control of the cell cycle progression via the regulation of S phase and cyclin A (show CCNA2 Antibodies), cyclin B, and CDK1 (show CDK1 Antibodies)

  8. The repressor complex that Mip (show MIP Antibodies)/LIN-9 (show LIN9 Antibodies) forms with p107 (show RBL1 Antibodies) takes functional precedence over the transcriptional activation linked to the Mip (show MIP Antibodies)/LIN-9 (show LIN9 Antibodies) and B-Myb (show MYBL2 Antibodies) interaction.

  9. Lin-9 (show LIN9 Antibodies) and B-Myb (show MYBL2 Antibodies) were both required for transcription of G(2)/M genes such as Cyclin B1 (show CCNB1 Antibodies) and Survivin (show BIRC5 Antibodies).

  10. Mip130/LIN-9 (show LIN9 Antibodies) contributes to the repression of these E2F (show E2F1 Antibodies)-regulated genes in G0/G1 in mice.

Human Trimethylguanosine Synthase 1 (TGS1) interaction partners

  1. Data highlight the importance of the catalytic activity of PIMT to mediate VEGF effects during endothelial cell migration and tube formation in angiogenesis.

  2. PIMT (show PCMT1 Antibodies) was identified as a key player responsible for glycated low density lipoproteins induced vascular endothelial cell apoptosis.

  3. isoforms of the PIMT/Tgs1 protein with an RNA methyltransferase domain function both in the nucleus and in the cytoplasm

  4. The protein L-isoaspartyl (D-aspartyl) methyltransferase (PIMT (show PCMT1 Antibodies)) is an enzyme that recognizes and repairs the abnormal L-isoaspartyl residues in proteins.

  5. Interaction of PIMT (show PCMT1 Antibodies) with transcriptional coactivators CBP (show CREBBP Antibodies), p300 (show EP300 Antibodies), and PBP (show DOCK3 Antibodies) differential role in transcriptional regulation.

  6. proteasome maturation constitutes a mechanism regulating Tgs1 (show LIN9 Antibodies) function by generating Tgs1 (show LIN9 Antibodies) species with different substrate specificities, subcellular localizations, and functions.

  7. These results highlight that PIMT (show PCMT1 Antibodies) expression is regulated by ROS (show ROS1 Antibodies) and could primarily act as an antioxidant enzyme.

  8. present a biochemical characterization of the human Tgs1 (show LIN9 Antibodies) guanine-N2 methyltransferase reaction and identify individual amino acids required for methyltransferase activity in vitro and in vivo

  9. m(7)GpppA binds via its adenosine moiety to the structurally conserved adenosylmethionine-binding pocket. The m(7) guanosine is unbound. The crystallized TGS1 (show LIN9 Antibodies) fragment is catalytically inactive, but a fragment that is 17 AAs (show FGD1 Antibodies) longer exhibits activity.

  10. The crystal structure of the substrate bound methyltransferase domain as well as mutagenesis studies provide insight into the catalytic mechanism of TGS1 (show LIN9 Antibodies).

TGS1 Antigen Profile

Protein Summary

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation (By similarity).

Gene names and symbols associated with TGS1

  • trimethylguanosine synthase 1 (TGS1) antibody
  • trimethylguanosine synthase homolog (LOC100339300) antibody
  • lin-9 homolog (C. elegans) (Lin9) antibody
  • trimethylguanosine synthase 1 (tgs1) antibody
  • trimethylguanosine synthase 1 (Tgs1) antibody
  • trimethylguanosine synthase homolog (S. cerevisiae) (Tgs1) antibody
  • 2700022J23Rik antibody
  • AA537062 antibody
  • AA545216 antibody
  • Bara antibody
  • D4Ertd800e antibody
  • Ncoa6ip antibody
  • Pimt antibody
  • PIPMT antibody
  • TGS antibody
  • TGS1 antibody

Protein level used designations for TGS1

trimethylguanosine synthase homolog , TUDOR gene similar 1 protein , mLin-9 , protein lin-9 homolog , type I interferon receptor beta chain-associated protein , CLL-associated antigen KW-2 , PRIP-interacting protein PIPMT , PRIP-interacting protein with methyltransferase domain , PRIP-interacting protein with methyltransferase motif , SEREX-defined , cap-specific guanine-N2 methyltransferase , hepatocellular carcinoma-associated antigen 137 , nuclear receptor coactivator 6 interacting protein , nuclear receptor coactivator 6-interacting protein , trimethylguanosine synthase , PIMT , PIPMT

GENE ID SPECIES
695339 Macaca mulatta
100067973 Equus caballus
100218284 Taeniopygia guttata
100339300 Oryctolagus cuniculus
72568 Mus musculus
96764 Homo sapiens
444119 Xenopus laevis
421126 Gallus gallus
477885 Canis lupus familiaris
312947 Rattus norvegicus
116940 Mus musculus
Selected quality suppliers for anti-TGS1 (TGS1) Antibodies
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