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Trimethylguanosine Synthase 1 (TGS1) ELISA Kits

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. Additionally we are shipping TGS1 Antibodies (20) and TGS1 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse TGS1 TGS1 72568 Q8C735
Anti-Human TGS1 TGS1 96764 Q96RS0
Anti-Rat TGS1 TGS1 312947 P85107
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More ELISA Kits for TGS1 Interaction Partners

Mouse (Murine) Trimethylguanosine Synthase 1 (TGS1) interaction partners

  1. LIN9 (show LIN9 ELISA Kits) is essential for proliferation and genome stability of ESCs (show NR2E3 ELISA Kits) by activating genes with important functions in mitosis and cytokinesis

  2. PIMT (show PCMT1 ELISA Kits) is expressed in all cells of the E3.5day blastocyst in the mouse.

  3. inactivation of LIN9 (show LIN9 ELISA Kits), a subunit of DREAM, results in premature senescence, which can be overcome by the SV40 large T (LT) antigen

  4. These experiments provide the first direct genetic evidence for the role of LIN9 (show LIN9 ELISA Kits) in development and mitotic gene regulation and they suggest that it may function as a haploinsufficient tumor suppressor.

  5. there is a feedback mechanism between ARF and Mip130/LIN-9 (show LIN9 ELISA Kits) in which either the increase of ARF or the decrease in Mip130/LIN-9 (show LIN9 ELISA Kits)

  6. Mutation of BARA/LIN-9 (show LIN9 ELISA Kits) restores the expression of E2F (show E2F1 ELISA Kits) target genes in CDK4 (show CDK4 ELISA Kits) null Mouse Embryo Fibroblasts, indicating that the wild-type protein plays a role in the expression of genes required for the G1/S transition.

  7. Mip (show MIP ELISA Kits)/LIN-9 (show LIN9 ELISA Kits) is required for the expression of B-Myb (show MYBL2 ELISA Kits), and both proteins collaborate in the control of the cell cycle progression via the regulation of S phase and cyclin A (show CCNA2 ELISA Kits), cyclin B, and CDK1 (show CDK1 ELISA Kits)

  8. The repressor complex that Mip (show MIP ELISA Kits)/LIN-9 (show LIN9 ELISA Kits) forms with p107 (show RBL1 ELISA Kits) takes functional precedence over the transcriptional activation linked to the Mip (show MIP ELISA Kits)/LIN-9 (show LIN9 ELISA Kits) and B-Myb (show MYBL2 ELISA Kits) interaction.

  9. Lin-9 (show LIN9 ELISA Kits) and B-Myb (show MYBL2 ELISA Kits) were both required for transcription of G(2)/M genes such as Cyclin B1 (show CCNB1 ELISA Kits) and Survivin (show BIRC5 ELISA Kits).

  10. Mip130/LIN-9 (show LIN9 ELISA Kits) contributes to the repression of these E2F (show E2F1 ELISA Kits)-regulated genes in G0/G1 in mice.

Human Trimethylguanosine Synthase 1 (TGS1) interaction partners

  1. Data highlight the importance of the catalytic activity of PIMT to mediate VEGF effects during endothelial cell migration and tube formation in angiogenesis.

  2. PIMT (show PCMT1 ELISA Kits) was identified as a key player responsible for glycated low density lipoproteins induced vascular endothelial cell apoptosis.

  3. isoforms of the PIMT/Tgs1 protein with an RNA methyltransferase domain function both in the nucleus and in the cytoplasm

  4. The protein L-isoaspartyl (D-aspartyl) methyltransferase (PIMT (show PCMT1 ELISA Kits)) is an enzyme that recognizes and repairs the abnormal L-isoaspartyl residues in proteins.

  5. Interaction of PIMT (show PCMT1 ELISA Kits) with transcriptional coactivators CBP (show CREBBP ELISA Kits), p300 (show EP300 ELISA Kits), and PBP (show DOCK3 ELISA Kits) differential role in transcriptional regulation.

  6. proteasome maturation constitutes a mechanism regulating Tgs1 (show LIN9 ELISA Kits) function by generating Tgs1 (show LIN9 ELISA Kits) species with different substrate specificities, subcellular localizations, and functions.

  7. These results highlight that PIMT (show PCMT1 ELISA Kits) expression is regulated by ROS (show ROS1 ELISA Kits) and could primarily act as an antioxidant enzyme.

  8. present a biochemical characterization of the human Tgs1 (show LIN9 ELISA Kits) guanine-N2 methyltransferase reaction and identify individual amino acids required for methyltransferase activity in vitro and in vivo

  9. m(7)GpppA binds via its adenosine moiety to the structurally conserved adenosylmethionine-binding pocket. The m(7) guanosine is unbound. The crystallized TGS1 (show LIN9 ELISA Kits) fragment is catalytically inactive, but a fragment that is 17 AAs (show FGD1 ELISA Kits) longer exhibits activity.

  10. The crystal structure of the substrate bound methyltransferase domain as well as mutagenesis studies provide insight into the catalytic mechanism of TGS1 (show LIN9 ELISA Kits).

TGS1 Antigen Profile

Antigen Summary

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation (By similarity).

Gene names and symbols associated with TGS1

  • trimethylguanosine synthase 1 (TGS1) antibody
  • trimethylguanosine synthase homolog (LOC100339300) antibody
  • lin-9 homolog (C. elegans) (Lin9) antibody
  • trimethylguanosine synthase 1 (tgs1) antibody
  • trimethylguanosine synthase 1 (Tgs1) antibody
  • trimethylguanosine synthase homolog (S. cerevisiae) (Tgs1) antibody
  • 2700022J23Rik antibody
  • AA537062 antibody
  • AA545216 antibody
  • Bara antibody
  • D4Ertd800e antibody
  • Ncoa6ip antibody
  • Pimt antibody
  • PIPMT antibody
  • TGS antibody
  • TGS1 antibody

Protein level used designations for TGS1

trimethylguanosine synthase homolog , TUDOR gene similar 1 protein , mLin-9 , protein lin-9 homolog , type I interferon receptor beta chain-associated protein , CLL-associated antigen KW-2 , PRIP-interacting protein PIPMT , PRIP-interacting protein with methyltransferase domain , PRIP-interacting protein with methyltransferase motif , SEREX-defined , cap-specific guanine-N2 methyltransferase , hepatocellular carcinoma-associated antigen 137 , nuclear receptor coactivator 6 interacting protein , nuclear receptor coactivator 6-interacting protein , trimethylguanosine synthase , PIMT , PIPMT

GENE ID SPECIES
695339 Macaca mulatta
100067973 Equus caballus
100218284 Taeniopygia guttata
100339300 Oryctolagus cuniculus
72568 Mus musculus
96764 Homo sapiens
444119 Xenopus laevis
421126 Gallus gallus
477885 Canis lupus familiaris
312947 Rattus norvegicus
116940 Mus musculus
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