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Triosephosphate Isomerase 1 Proteins (TPI1)

TPI1 encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Additionally we are shipping Triosephosphate Isomerase 1 Antibodies (74) and Triosephosphate Isomerase 1 Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Human TPI1 TPI1 7167 P60174
Mouse TPI1 TPI1 21991 P17751
Rat TPI1 TPI1 24849 P48500
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Top Triosephosphate Isomerase 1 Proteins at antibodies-online.com

Showing 10 out of 142 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Mesocricetus auratus His tag   1 mg Log in to see 56 to 66 Days
$2,449.33
Details
Yeast Methanosarcina His tag   1 mg Log in to see 56 to 66 Days
$2,553.83
Details
Yeast Methanothermus His tag   1 mg Log in to see 56 to 66 Days
$2,553.83
Details
Yeast Caldivirga maquilingensis His tag   1 mg Log in to see 56 to 66 Days
$2,563.00
Details
Yeast Methanopyrus kandleri His tag   1 mg Log in to see 56 to 66 Days
$2,566.67
Details
Yeast Methanobacteriaceae His tag   1 mg Log in to see 56 to 66 Days
$2,566.67
Details

TPI1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced Triosephosphate Isomerase 1 Proteins

  1. Human TPI1 Protein expressed in Escherichia coli (E. coli) - ABIN667249 : Maquat, Chilcote, Ryan: Human triosephosphate isomerase cDNA and protein structure. Studies of triosephosphate isomerase deficiency in man. in The Journal of biological chemistry 1985 (PubMed)
    Show all 2 references for ABIN667249

  2. Human TPI1 Protein expressed in Wheat germ - ABIN1323426 : Yang, Xiao, Zhang, Li, Zhang, Li, Chen, Zhu, Sun, Liu, Chen: Identification of tumor antigens in human lung squamous carcinoma by serological proteome analysis. in Journal of proteome research 2007 (PubMed)

More Proteins for Triosephosphate Isomerase 1 (TPI1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Triosephosphate Isomerase 1 (TPI1) interaction partners

  1. our findings are the first to identify, to our knowledge, a functional synaptic defect in TPI deficiency derived from molecular changes in the TPI dimer interface.

  2. TPI sugarkill can be genetically complemented by TPI encoding a catalytically inactive enzyme.

  3. Mutation of wasted away, a recessive, hypomorphic mutation of triosephosphate isomerase (Tpi), highlights the essential protective role of triosephosphate isomerase.

Pig (Porcine) Triosephosphate Isomerase 1 (TPI1) interaction partners

  1. Sperm TPI content and amounts of GPX5 in seminal plasma may be used as quality markers of boar sperm.

Human Triosephosphate Isomerase 1 (TPI1) interaction partners

  1. our findings are the first to identify, to our knowledge, a functional synaptic defect in TPI deficiency derived from molecular changes in the TPI dimer interface.

  2. Polyvinylpyrrolidone stabilised silver nanoparticles (60 nM; 2-6 nm diameter) selectively inhibited PfTIM with a 7-fold decrease in enzyme catalytic efficiency (K(cat)/K(m)) over hTIM.

  3. results suggest amyloid-beta oligomers induce neuronal death by triggering methylglyoxal(MG) production; increased release of MG is a direct consequence of triosephosphate isomerase nitrotyrosination due to amyloid-beta peptide action at the 2 tyrosines associated with the catalytic center

  4. TPI-PEP (show PAEP Proteins) co-crystal structure, demonstrating that PEP (show PAEP Proteins) directly binds into the catalytic pocket of TPI.

  5. Data suggest that exchange reactions during gluconeogenesis catalyzed by triose-phosphate isomerase and transaldolase (show TALDO1 Proteins) do not differ between subjects with type 2 diabetes and control subjects under fasting or hyperglycemic conditions.

  6. we review the relationship between modified TPI and Alzheimer disease (AD), highlighting the relevance of this protein in AD pathology

  7. study found promoter SNPs of CKB (show CHKB Proteins) and TPI1 were weakly associated with schizophrenia;in addition, IFNG (show IFNG Proteins) polymorphisms were associated with schizophrenia; results suggest that IFNG (show IFNG Proteins) and proteins affected by IFNG (show IFNG Proteins) may play a role in the pathogenesis of schizophrenia

  8. [Review] The activity of glycolytic enzyme TPI reveals a mechanistic link between energy metabolism and age-related proteostatic dysfunction which can suppress generation of altered proteins that characterize the aged phenotype in cells and tissues.

  9. A patient with triosephosphate isomerase-deficiency was found to be homozygous for a Val231Met mutation.

  10. structural changes rather than abnormal catalysis may play an important role in the clinical manifestations of TPI deficiency; the postulated high aggregation ability of the unstable Glu104Asp mutant would lead to more serious symptoms

Mouse (Murine) Triosephosphate Isomerase 1 (TPI1) interaction partners

  1. TPI interacts with Tau protein in a normal, nondisease state as well as in a neurodegenerative state.

  2. Triosephosphate isomerase activity-deficient mice show haemolytic anaemia in homozygous condition

Xenopus laevis Triosephosphate Isomerase 1 (TPI1) interaction partners

  1. data indicate that Tipin (show TIPIN Proteins)/Tim1/And1 (show WDHD1 Proteins) form a complex that links stabilization of replication fork and establishment of sister chromatid cohesion

Triosephosphate Isomerase 1 (TPI1) Protein Profile

Protein Summary

This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with TPI1

  • triosephosphate isomerase-like (LOC100052671)
  • Triose phosphate isomerase (Tpi)
  • triosephosphate isomerase 1 (TPI1)
  • triosephosphate isomerase 1 (tpi1)
  • triosephosphate isomerase (Tpi)
  • triose-phosphate isomerase (tpiA)
  • triose-phosphate isomerase (CNE05000)
  • Triose-phosphate isomerase (Fnod_0738)
  • Triose-phosphate isomerase (Tlet_0996)
  • Triose-phosphate isomerase (Sare_3323)
  • triose-phosphate isomerase (PKH_126640)
  • triose-phosphate isomerase (TPI2)
  • triose-phosphate isomerase (TPI1)
  • Protein TPI-1 (tpi-1)
  • triosephosphate isomerase 1 (Tpi1)
  • triosephosphate isomerase 1 (LOC100348316)
  • AI255506 protein
  • CG2171 protein
  • Dmel\\CG2171 protein
  • GB17473 protein
  • ND14 protein
  • sgk protein
  • TIM protein
  • Tpi protein
  • Tpi-1 protein
  • tpi1 protein
  • TPIS protein
  • wstd protein

Protein level used designations for TPI1

CG2171-PA , CG2171-PB , CG2171-PC , Tpi-PA , Tpi-PB , Tpi-PC , neurodegeneration 14 , sugarkill , triose phosphate isomerase , triosephosphate isomerase , wasted away , triosephosphate isomerase 1 , Triose-phosphate isomerase , triosephoshpate isomerase , triose-phosphate isomerase , TIM , triosephosphate isomerase (TIM, D-glyceraldehyde 3-phosphate ketol-isomerase)

GENE ID SPECIES
100052671 Equus caballus
43582 Drosophila melanogaster
641360 Sus scrofa
706960 Macaca mulatta
714090 Macaca mulatta
100038162 Xenopus (Silurana) tropicalis
100303510 Saccoglossus kowalevskii
726117 Apis mellifera
2780469 Candidatus Protochlamydia amoebophila UWE25
3257746 Cryptococcus neoformans var. neoformans JEC21
5452732 Fervidobacterium nodosum Rt17-B1
5608745 Thermotoga lettingae TMO
5703815 Salinispora arenicola CNS-205
7322077 Plasmodium knowlesi strain H
7444271 Thalassiosira pseudonana CCMP1335
7448577 Thalassiosira pseudonana CCMP1335
174844 Caenorhabditis elegans
7167 Homo sapiens
21991 Mus musculus
477711 Canis lupus familiaris
100157582 Sus scrofa
281543 Bos taurus
24849 Rattus norvegicus
396435 Gallus gallus
100348316 Oryctolagus cuniculus
451799 Pan troglodytes
100172948 Pongo abelii
380168 Xenopus laevis
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