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The protein encoded by TRIM24 mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. Additionally we are shipping TRIM24 Proteins (7) and TRIM24 Kits (1) and many more products for this protein.
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Human Monoclonal TRIM24 Primary Antibody for IF, IHC (p) - ABIN563797
Kikuchi, Okumura, Tsukiyama, Watanabe, Miyajima, Tanaka, Imamura, Hatakeyama: TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells. in Biochimica et biophysica acta 2009
Show all 3 references for ABIN563797
Human Polyclonal TRIM24 Primary Antibody for WB - ABIN2780554
Yondola, Hearing: The adenovirus E4 ORF3 protein binds and reorganizes the TRIM family member transcriptional intermediary factor 1 alpha. in Journal of virology 2007
Human Polyclonal TRIM24 Primary Antibody for IHC, ELISA - ABIN184911
Thénot, Henriquet, Rochefort, Cavaillès: Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. in The Journal of biological chemistry 1997
TRIM24 is overexpressed in human bladder cancer and facilitates bladder cancer growth and invasion, possibly through NF-kappaB (show NFKB1 Antibodies) and AKT (show AKT1 Antibodies) signaling pathways.
functions as an oncogene (show RAB1A Antibodies) in colorectal carcinogenesis
A role for TRIM24 in breast tumorigenesis through reprogramming of glucose metabolism in human mammary epithelial cells, further supporting TRIM24 as a viable therapeutic target in breast cancer.
our study shows that TRIM24 is overexpressed in human gastric cancer and accelerates cell growth as well as induce chemoresistance
Our results suggest that TRIM24 might serve as a potential prognostic marker and therapeutic target for the management of malignant gliomas.
Study shows that TRIM24 is destabilized by ATM (show ATM Antibodies)-mediated phosphorylation of TRIM24S768 in response to DNA damage, which disrupts TRIM24-p53 (show TP53 Antibodies) interactions and promotes the degradation of TRIM24.
Overexpression of TRIM24 is associated with the onset and progress of human hepatocellular carcinoma.
Upon TRIM24 silencing, the proliferation of HNSCC cells was notably inhibited due to the induction of apoptosis.
TRIM24 plays an important role in NSCLC progression
These results suggest that E4-ORF3 (show ASZ1 Antibodies) targets proteins for relocalization through a loosely homologous sequence dependent on accessibility.
data identify a previously unappreciated Trim24-dependent requirement for IL-1R expression on TH2 cells and an important nonredundant role for T-cell-intrinsic Trim24 in TH2-mediated allergy and antihelminth immunity
Trim24 repressed VL30-class endogenous retroviruses retrotransposons
These results identify Trim24 as a novel negative regulator of the IFN/STAT (show STAT1 Antibodies) pathway and suggest that this repression through Rara (show RARA Antibodies) inhibition may prevent liver cancer.
Somatic hepatocyte-specific inactivation of TRIM24, TRIM28 (show TRIM28 Antibodies), or TRIM33 (show TRIM33 Antibodies) all promote hepatocellular carcinoma in a cell-autonomous manner in mice.
TRIM24 regulates AR-mediated transcription in collaboration with TIP60 (show KAT5 Antibodies) and BRD7 (show BRD7 Antibodies).
TIF1alpha-chromatin association is direct and involves DNA and nucleosome interactions mediated by the bromodomain
These studies indicate that TIF1alpha is a factor that modulates the expression of a set of genes during the first wave of genome activation in the mouse embryo.
The results not only provide genetic evidence that Trim24 and Rara (show RARA Antibodies) co-regulate hepatocarcinogenesis in an antagonistic manner but also suggest that aberrant activation of Rara (show RARA Antibodies) is deleterious to liver homeostasis.
TIF1alpha-null mutant pathological phenotype supports the hypothesis that aging is promoted by increased activity of the vitamin D signaling pathway
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
tripartite motif-containing 24
, transcriptional intermediary factor 1 alpha
, tripartite motif containing 24
, E3 ubiquitin-protein ligase TRIM24
, RING finger protein 82
, transcription intermediary factor 1-alpha
, transcriptional intermediary factor 1
, E3 ubiquitin-protein ligase Trim24
, transcriptional intermediary factor 1, alpha
, tripartite motif-containing protein 24