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Tripartite Motif Containing 24 Proteins (TRIM24)

The protein encoded by TRIM24 mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. Additionally we are shipping TRIM24 Antibodies (110) and TRIM24 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRIM24 8805 O15164
TRIM24 21848 Q64127
Rat TRIM24 TRIM24 500084  
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Top TRIM24 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His tag,DYKDDDDK Tag Recombinant TRIM24 (862-980) protein gel. TRIM24 (862-980) protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 100 μg Log in to see 1 to 2 Days
$460.83
Details

TRIM24 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)

Top referenced TRIM24 Proteins

  1. Human TRIM24 Protein expressed in Wheat germ - ABIN1323631 : Fujimoto, Hamaguchi, Kaji, Matsushita, Ichimura, Kodera, Ishiguro, Ueda-Hayakawa, Asano, Ogawa, Fujikawa, Miyagi, Mabuchi, Hirose, Akimoto, Hatta, Tsutsui, Higashi, Igarashi, Seishima, Hasegawa et al.: Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins. ... in Arthritis and rheumatism 2012 (PubMed)
    Show all 2 references for ABIN1323631

More Proteins for Tripartite Motif Containing 24 (TRIM24) Interaction Partners

Human Tripartite Motif Containing 24 (TRIM24) interaction partners

  1. TRIM24 regulate resistance to Gefitinib via Akt (show AKT1 Proteins) pathway in non-small cell lung cancer cells.

  2. TRIM24 is overexpressed in human bladder cancer and facilitates bladder cancer growth and invasion, possibly through NF-kappaB (show NFKB1 Proteins) and AKT (show AKT1 Proteins) signaling pathways.

  3. functions as an oncogene (show RAB1A Proteins) in colorectal carcinogenesis

  4. A role for TRIM24 in breast tumorigenesis through reprogramming of glucose metabolism in human mammary epithelial cells, further supporting TRIM24 as a viable therapeutic target in breast cancer.

  5. our study shows that TRIM24 is overexpressed in human gastric cancer and accelerates cell growth as well as induce chemoresistance

  6. Our results suggest that TRIM24 might serve as a potential prognostic marker and therapeutic target for the management of malignant gliomas.

  7. Study shows that TRIM24 is destabilized by ATM (show ATM Proteins)-mediated phosphorylation of TRIM24S768 in response to DNA damage, which disrupts TRIM24-p53 (show TP53 Proteins) interactions and promotes the degradation of TRIM24.

  8. Overexpression of TRIM24 is associated with the onset and progress of human hepatocellular carcinoma.

  9. Upon TRIM24 silencing, the proliferation of HNSCC cells was notably inhibited due to the induction of apoptosis.

  10. TRIM24 plays an important role in NSCLC progression

Mouse (Murine) Tripartite Motif Containing 24 (TRIM24) interaction partners

  1. data identify a previously unappreciated Trim24-dependent requirement for IL-1R expression on TH2 cells and an important nonredundant role for T-cell-intrinsic Trim24 in TH2-mediated allergy and antihelminth immunity

  2. Trim24 repressed VL30-class endogenous retroviruses retrotransposons

  3. These results identify Trim24 as a novel negative regulator of the IFN/STAT (show STAT1 Proteins) pathway and suggest that this repression through Rara (show RARA Proteins) inhibition may prevent liver cancer.

  4. Somatic hepatocyte-specific inactivation of TRIM24, TRIM28 (show TRIM28 Proteins), or TRIM33 (show TRIM33 Proteins) all promote hepatocellular carcinoma in a cell-autonomous manner in mice.

  5. TRIM24 regulates AR-mediated transcription in collaboration with TIP60 (show KAT5 Proteins) and BRD7 (show BRD7 Proteins).

  6. TIF1alpha-chromatin association is direct and involves DNA and nucleosome interactions mediated by the bromodomain

  7. These studies indicate that TIF1alpha is a factor that modulates the expression of a set of genes during the first wave of genome activation in the mouse embryo.

  8. The results not only provide genetic evidence that Trim24 and Rara (show RARA Proteins) co-regulate hepatocarcinogenesis in an antagonistic manner but also suggest that aberrant activation of Rara (show RARA Proteins) is deleterious to liver homeostasis.

  9. TIF1alpha-null mutant pathological phenotype supports the hypothesis that aging is promoted by increased activity of the vitamin D signaling pathway

TRIM24 Protein Profile

Protein Summary

The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with TRIM24

  • tripartite motif-containing 24 (TRIM24)
  • tripartite motif-containing 24 (trim24)
  • tripartite motif containing 24 (TRIM24)
  • tripartite motif containing 24 (trim24)
  • tripartite motif-containing 24 (Trim24)
  • A130082H20Rik protein
  • AI447469 protein
  • D430004I05Rik protein
  • hTIF1 protein
  • ptc6 protein
  • rnf82 protein
  • tf1a protein
  • tif1 protein
  • TIF1-alpha protein
  • Tif1a protein
  • TIF1alpha protein
  • TRIM24 protein

Protein level used designations for TRIM24

tripartite motif-containing 24 , transcriptional intermediary factor 1 alpha , tripartite motif containing 24 , E3 ubiquitin-protein ligase TRIM24 , RING finger protein 82 , TIF1-alpha , transcription intermediary factor 1-alpha , transcriptional intermediary factor 1 , E3 ubiquitin-protein ligase Trim24 , transcriptional intermediary factor 1, alpha , tripartite motif-containing protein 24 , Ab2-427

GENE ID SPECIES
418106 Gallus gallus
463762 Pan troglodytes
537246 Bos taurus
710229 Macaca mulatta
100158542 Xenopus (Silurana) tropicalis
100348283 Oryctolagus cuniculus
100548578 Meleagris gallopavo
100558013 Anolis carolinensis
100597413 Nomascus leucogenys
8805 Homo sapiens
495130 Xenopus laevis
21848 Mus musculus
500084 Rattus norvegicus
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