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The protein encoded by TRIM25 is a member of the tripartite motif (TRIM) family. Additionally we are shipping TRIM25 Proteins (5) and TRIM25 Kits (1) and many more products for this protein.
Showing 10 out of 125 products:
Human Polyclonal TRIM25 Primary Antibody for BCA - ABIN2666116
Gack, Kirchhofer, Shin, Inn, Liang, Cui, Myong, Ha, Hopfner, Jung: Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction. in Proceedings of the National Academy of Sciences of the United States of America 2008
Show all 4 references for ABIN2666116
Human Polyclonal TRIM25 Primary Antibody for EIA, IF - ABIN501046
Inoue, Orimo, Hosoi, Kondo, Toyoshima, Kondo, Ikegami, Ouchi, Orimo, Muramatsu: Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein. in Proceedings of the National Academy of Sciences of the United States of America 1994
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Human Polyclonal TRIM25 Primary Antibody for EIA, IF - ABIN501044
Orimo, Inoue, Minowa, Tominaga, Tomioka, Sato, Kuno, Hiroi, Shimizu, Suzuki, Noda, Muramatsu: Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein gene, which is a direct target of estrogen receptor alpha. in Proceedings of the National Academy of Sciences of the United States of America 1999
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TRIM25 plays an additional role in RIG-I (show DDX58 Antibodies)/MDA5 (show IFIH1 Antibodies) signaling other than RIG-I (show DDX58 Antibodies) ubiquitination via activation of NF-kappaB (show NFKB1 Antibodies).
Data show that TRIM25 enhances p53 (show TP53 Antibodies) and Mdm2 (show MDM2 Antibodies) abundance by preventing their proteasomal degradation. At the same time, TRIM25 inhibits p53 (show TP53 Antibodies)'s transcriptional activity and dampens the response to DNA damage.
The PR-2B DENV-2 produced increased levels of subgenomic flavivirus RNA (sfRNA) relative to genomic RNA during replication. PR-2B sfRNA showed sequence dependent binding to and prevention of tripartite motif 25 (TRIM25) deubiquitylation, which is critical for sustained and amplified retinoic acid-inducible gene 1 (show RARRES3 Antibodies) (RIG-I (show DDX58 Antibodies))-induced type I interferon (show IFNA Antibodies) expression.
Trim25 binds to the conserved terminal loop (CTL) of pre-let-7 and activates TuT4 (show ZCCHC11 Antibodies), allowing for more efficient Lin28a (show LIN28A Antibodies)-mediated uridylation.
Our data uncovers a previously unknown functional link between gp78 (show AMFR Antibodies) and TRIM25 and provides mechanistic insight into gp78 (show AMFR Antibodies)-mediated protein ubiquitylation.
Data indicate ubiquitin-specific protease 15 (USP15 (show USP15 Antibodies)) as a critical regulator of the tripartite motif protein 25 (TRIM25)- and RNA sensor retinoic acid-inducible gene-I (RIG-I (show DDX58 Antibodies))-mediated antiviral immune response
In controls, RNF125 (show RNF125 Antibodies) is the highest expressed gene, whereas in HIV infection progressors, RIG-I (show DDX58 Antibodies) is either the highest expressed gene or is expressed similarly to RNF125 (show RNF125 Antibodies) and TRIM25.
Study reports that RLR (show DHX58 Antibodies) activation triggers MAVS (show MAVS Antibodies) ubiquitination on lysine 7 and 10 by the E3 ubiquitin ligase (show MUL1 Antibodies) TRIM25 and marks it for proteasomal degradation concomitantly with downstream signaling.
14-3-3epsilon is essential for the stable interaction of RIG-I (show DDX58 Antibodies) with TRIM25, which facilitates RIG-I (show DDX58 Antibodies) ubiquitination and initiation of innate immunity against hepatitis C virus and other pathogenic RNA viruses.
EFP mediates estrogen-induced ATBF1 (show ZFHX3 Antibodies) protein degradation in breast cancer cells.
Two key residues (Asp (show C3 Antibodies)(488) and Trp (show TYRP1 Antibodies)(621)) in the TRIM25 B30.2 domain are critical for binding to the RIG-I (show DDX58 Antibodies) CARDs.
Two well-known E3 ubiquitin ligases, Trim25 (also called Efp) and Trim71 (show TRIM71 Antibodies) (also called Lin41 (show TRIM71 Antibodies)), are validated as RNA-binding proteins, revealing a potential link between RNA biology and protein-modification pathways.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.
tripartite motif-containing 25
, E3 ubiquitin/ISG15 ligase TRIM25
, tripartite motif containing 25
, RING finger protein 147
, estrogen-responsive finger protein
, tripartite motif protein TRIM25
, tripartite motif-containing protein 25
, ubiquitin/ISG15-conjugating enzyme TRIM25
, zinc finger protein 147 (estrogen-responsive finger protein)
, zinc finger protein-147
, tripartite motif protein 25
, zinc finger protein 147