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anti-Tripartite Motif Containing 5 (TRIM5) Antibodies

The protein encoded by TRIM5 is a member of the tripartite motif (TRIM) family. Additionally we are shipping TRIM5 Proteins (19) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TRIM5 85363 Q9C035
Anti-Mouse TRIM5 TRIM5 667823  
Anti-Rat TRIM5 TRIM5 308906  
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Top anti-TRIM5 Antibodies at antibodies-online.com

Showing 10 out of 151 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-TRIM5 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: PANC1 cell lysate WB Suggested Anti-TRIM5  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: PANC1 cell lysate  TRIM5 is supported by BioGPS gene expression data to be expressed in PANC1 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN184983 staining (1 ug/ml) of Human Brain lysate (RIPA buffer, 35 ug total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. ABIN184983 (1 ug/ml) staining of paraffin embedded Human Tonsil. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining.  A) positive cells next to a secondary follicle, B) positive cells below tonsillar epithelium. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of TRIM5 gamma in human bladder tissue with TRIM5 gamma antibody at 2 μg/ml. Western blot analysis of TRIM5 gamma expression in human bladder (A) and colon (B) cell lysate with TRIM5 gamma antibody at 2 μg /ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemical staining of human stomach using AP30950PU-N at 2 μg/ml. Western blot analysis of TRIM5 alpha expression in human stomach (A), thymus (B), and uterus (C) cell lysate with this product at 2 μg /ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, IF, WB Immunofluorescence of TRIM5 alpha in human breast tissue with this product at 10 μg/ml. Western blot analysis of TRIM5 alpha expression in human stomach (A), thymus (B), and uterus (C) cell lysate with this product at 2 μg /ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of TRIM5 delta in mouse brain tissue with this product at 1 μg/ml. Western blot analysis of TRIM5 delta expression in mouse brain cell lysate with TRAP30953PU-N at 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated IHC, ELISA, WB Figure 1: Immunohistochemical analysis of paraffin-embedded human metastatic adenocarcinoma (A) and stomach adenocarcinoma (B), showing cytoplasmic localization using Trim5α mouse mAb with AEC staining (A) and DAB staining (B) . Figure 2: Western blot analysis using Trim5α mouse mAb against human breast carcinoma tissue lysate. 100 μL Log in to see 3 to 4 Days
$442.20
Details
Human Goat Un-conjugated IHC, ELISA, WB   100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Goat Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated WB TRIM5 Antibody (C-term) (ABIN655693) western blot analysis in NCI-H292 cell line lysates (35 µg/lane). This demonstrates the TRIM5 antibody detected the TRIM5 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details

TRIM5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-TRIM5 Antibodies

  1. Human Polyclonal TRIM5 Primary Antibody for EIA, IHC (p) - ABIN501058 : Reymond, Meroni, Fantozzi, Merla, Cairo, Luzi, Riganelli, Zanaria, Messali, Cainarca, Guffanti, Minucci, Pelicci, Ballabio: The tripartite motif family identifies cell compartments. in The EMBO journal 2001 (PubMed)
    Show all 4 references for ABIN501058

  2. Human Monoclonal TRIM5 Primary Antibody for IHC, ELISA - ABIN969443 : Keckesova, Ylinen, Towers: The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities. in Proceedings of the National Academy of Sciences of the United States of America 2004 (PubMed)
    Show all 3 references for ABIN969443

  3. Human Polyclonal TRIM5 Primary Antibody for EIA, IF - ABIN501054 : Stremlau, Owens, Perron, Kiessling, Autissier, Sodroski: The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys. in Nature 2004 (PubMed)
    Show all 3 references for ABIN501054

  4. Human Polyclonal TRIM5 Primary Antibody for IHC, ELISA - ABIN185553 : Berthoux, Sebastian, Sokolskaja, Luban: Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)

  5. Human Polyclonal TRIM5 Primary Antibody for WB - ABIN2778419 : Yamauchi, Wada, Tanji, Tanaka, Kamitani: Ubiquitination of E3 ubiquitin ligase TRIM5 alpha and its potential role. in The FEBS journal 2008 (PubMed)

More Antibodies against TRIM5 Interaction Partners

Rabbit Tripartite Motif Containing 5 (TRIM5) interaction partners

  1. The Sylvilagus TRIM5 alpha was 91% identical to the Oryctolagus protein.

Human Tripartite Motif Containing 5 (TRIM5) interaction partners

  1. This meta-analysis indicates that TRIM5alpha H43Y polymorphism is associated with a decreased risk of HIV-1 infection in the homozygote comparison and recessive model.

  2. higher-order oligomerization of TRIM5alpha, which is promoted by the interaction with the retroviral capsid, enhances the E3 Ub ligase activity of TRIM5alpha and contributes to its antiretroviral function.

  3. TRIM5alpha requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.

  4. co-immunoprecipitation experiments demonstrate that IE1CORE binds via the coiled-coil domain to PML (show PML Antibodies) and also interacts with TRIM5alpha

  5. TRIM5alpha variations influence transduction efficiency with lentiviral vectors in both human and rhesus CD34 (show CD34 Antibodies)(+) cells in vitro and in vivo.

  6. TRIM5 acts as a selective autophagy receptor. Based on direct sequence-specific recognition, TRIM5 delivered its cognate cytosolic target, a viral capsid protein, for autophagic degradation. Thus, our study establishes that TRIMs can function both as regulators of autophagy and as autophagic cargo receptors, and reveals a basis for selective autophagy in mammalian cells.

  7. TRIM5alpha and TRIM22 (show TRIM22 Antibodies) have differential transcriptional regulation and distinct anti-HIV roles according to infection phase.

  8. In conclusion, association with microtubules and the translocation activity of dynein motor complexes are required to achieve efficient retrovirus restriction by TRIM5alpha.

  9. Data report that markers in two TRIMs, TRIM5 and TRIM22 (show TRIM22 Antibodies) and a marker in BST2 (show BST2 Antibodies), associated statistically with the risk of getting MS.

  10. Our data indicate that although the RhTRIMe7-CypA (show PPIA Antibodies) isoform does not appear to restrict HIV-1, it may act as a negative modulator of TRIM (show TRAT1 Antibodies) family proteins, presumably by competitive inhibition

Rhesus Monkey Tripartite Motif Containing 5 (TRIM5) interaction partners

  1. Mutations in gag and pol are associated with escape of HIV-1 from rhTrim5alpha.

  2. These studies provide direct evidence that ubiquitin conjugation to rhTRIM5alpha-containing complexes is required for inhibition of HIV-1 Reverse Transcription and Capsid Destabilization.

  3. These results confirm that the SUMO machinery is involved in TRIM5alpha-mediated retroviral restriction, and demonstrate that TRIM5alpha is a SUMO 1 (show SUMO1 Antibodies) and SUMO 2 (show SUMO2 Antibodies) substrate.

  4. These data show that there could be some distinct HIV-1 capsid patterns to confer significant resistance to rhesus TRIM5-alpha.

  5. Authors found that TRIM5alpha restriction significantly delayed disease progression and improved the survival rate of simian immunodeficiency virus-infected macaques.

  6. Analysis of TRIM genotype revealed a potential role for TRIM in disease development in the central nervous system. 5 of 5 animals with the permissive TRIM5alpha genotype (TRIMQ/Q) progressed to Simian Immunodeficiency Virus Encephalitis. In contrast, 2 animals with the restrictive TRIM5alpha genotype (TRIMTFP/TFP) did not show neurologic signs, nor did they develop SIVE.

  7. Rhesus TRIM5alpha acts as an autophagic receptor to restrict HIV-1 through autophagic degradation.

  8. In conclusion, the TRIM5alpha sumoylation site appears to modulate the E3 ubiquitin ligase activities of the adjacent RING domain, promoting K63-linked ubiquitin chains at the expense of auto-ubiquitylation which is probably K48-linked.

  9. The antiparallel organization of the NtD regions of Fv1 and Trim5alpha dimers correctly positions C-terminal specificity and N-terminal effector domains and facilitates stable binding to adjacent capsid hexamers in viral cores.

  10. Taken together, it is likely that rhTRIM5alpha cytoplasmic bodies are involved in recruiting components of the ubiquitin-proteasome system to coordinate proteasomal destruction of a viral or cellular protein(s) during restriction of HIV-1.

Chimpanzee Tripartite Motif Containing 5 (TRIM5) interaction partners

  1. TRIM5alpha protein functionally resembled human TRIM5alpha, potently restricting infection by N-tropic murine leukemia virus (N-MLV) and moderately restricting human immunodeficiency virus type 1 (HIV-1) infection

  2. SPRY domain of TRIM5alpha showed higher nonsynon/synonymous substitution ratios than the non-SPRY domain, indicating that the adaptive evolution of TRIM5alpha might be a strategy developed in defending retrovirus infection during primate evolution.

TRIM5 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with TRIM5

  • tripartite motif-containing 5 (TRIM5) antibody
  • tripartite motif containing 5 (TRIM5) antibody
  • tripartite motif-containing 5 (Trim5) antibody
  • EG667823 antibody
  • Gm8833 antibody
  • RGD1304579 antibody
  • RNF88 antibody
  • TRIM5 antibody
  • TRIM5alpha antibody

Protein level used designations for TRIM5

tripartite motif-containing 5 , TRIM5alpha , tripartite motif-containing 5 alpha , tripartite motif-containing protein 5 , tri-partite motif protein 5 , ring finger protein 88 , tripartite motif containing 5 transcript variant iota , tripartite motif containing 5 transcript variant kappa , tripartite motif protein TRIM5 , tripartite motif-containing protein 5 isoform alpha , TRIM5 alpha

GENE ID SPECIES
100126072 Oryctolagus cuniculus
100126714 Papio anubis
100302544 Felis catus
85363 Homo sapiens
574288 Macaca mulatta
100984455 Pan paniscus
100137088 Pongo abelii
503563 Pan troglodytes
667823 Mus musculus
308906 Rattus norvegicus
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