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The protein encoded by TRIM8 is a member of the tripartite motif (TRIM) family. Additionally we are shipping TRIM8 Antibodies (45) and TRIM8 Proteins (4) and many more products for this protein.
Our study provides evidences that TRIM8 may participate in the carcinogenesis and progression of glioma and that the transcriptional repression of TRIM8 might have potential value for predicting poor prognosis in glioma patients.
These findings provide the first mechanistic link between TRIM8 and the drug resistance of clear cell Renal Cell Carcinoma
Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene (show RAB1A ELISA Kits), is involved in positive regulation of TNF (show TNF ELISA Kits) induced NF-kappaB (show NFKB1 ELISA Kits) pathway.
TRIM8 is a p53 (show TP53 ELISA Kits) direct target gene that induces p53 (show TP53 ELISA Kits) stabilization and promotes the degradation of MDM2 (show MDM2 ELISA Kits) protein.
Tripartite motif 8 (TRIM8) modulates TNFalpha (show TNF ELISA Kits)- and IL-1beta (show IL1B ELISA Kits)-triggered NF-kappaB (show NFKB1 ELISA Kits) activation by targeting TAK1 (show MAP3K7 ELISA Kits) for K63-linked polyubiquitination.
TRIM8 modulates translocation of phosphorylated STAT3 into the nucleus through interaction with Hsp90beta and consequently regulates transcription of Nanog in embryonic stem cells.
These findings indicate that TRIM8 enhances the STAT3 (show STAT3 ELISA Kits)-dependent signal pathway by inhibiting the function of PIAS3 (show PIAS3 ELISA Kits).
interacts with SOCS-1 (show SOCS1 ELISA Kits)
Gerp transcribes interferon-gamma (show IFNG ELISA Kits) in epithelial and lymphoid cells and is expressed almost ubiquitously in tissues.
Among genes correlated to nodal metastatic progression, we verified in vitro that NM23-H3 reduced cell motility and TRIM8 were a growth suppressor.
TRIM8 has pro-inflammatory effect on Pseudomonas aeruginosa -induced keratitis
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes.
glioblastoma expressed ring finger protein
, glioblastoma-expressed RING finger protein
, probable E3 ubiquitin-protein ligase TRIM8
, ring finger protein 27
, tripartite motif protein TRIM8
, tripartite motif-containing 8
, tripartite motif-containing protein 8
, tripartite motif protein 8