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Tripeptidyl Peptidase II (Tpp2) ELISA Kits

Tpp2 encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. Additionally we are shipping Tpp2 Antibodies (13) and Tpp2 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human Tpp2 Tpp2 7174 P29144
Anti-Mouse Tpp2 Tpp2 22019 Q64514
Anti-Rat Tpp2 Tpp2 81815 Q64560
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More ELISA Kits for Tpp2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Tripeptidyl Peptidase II (Tpp2) interaction partners

  1. Previously unknown differences between TPP II orthologues and subtilisin as well as features that might be conserved within the entire family of subtilisin-like serine peptidases.

  2. a systematic kinetic analysis of wild type Drosophila melanogaster TPPII and five point mutants of the double-Glu (show SLC2A1 ELISA Kits)-motif (E312/E343) involving natural substrates were performed.

  3. The structure suggests a model for activation of TPP II involving the relocation of a flexible loop and a repositioning of the active-site serine, coupling it to holocomplex assembly and active-site sequestration.

  4. The 150 kDa subunits of TPPII form a superstructure composed of 2 segmented & twisted (show POMT2 ELISA Kits) strands. Each strand is 12.5 nm in width & composed of 11 segments that enclose a central channel.

  5. the unique spindle form of the holo-complex of TPP II represents an assembly motif stabilizing a highly active state

Arabidopsis thaliana Tripeptidyl Peptidase II (Tpp2) interaction partners

  1. The purification and characterization of tripeptidyl peptidase II from Arabidopsis thaliana is reported.

Human Tripeptidyl Peptidase II (Tpp2) interaction partners

  1. Novel interactions of TPPII, p53 (show TP53 ELISA Kits), and SIRT7 (show SIRT7 ELISA Kits) presented in this study might contribute to the knowledge of the regulatory effects of these proteins on apoptotic pathways and to the understanding mechanisms of aging and lifespan regulation.

  2. TPP2 mediates many important cellular functions by controlling ERK1 (show MAPK3 ELISA Kits) and ERK2 (show MAPK1 ELISA Kits) phosphorylation.

  3. Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with TPP2 deficiency have been described in two consanguineous siblings.

  4. Study found that autosomal recessive TPP2 mutations cause recurrent infections, autoimmunity, and neurodevelopmental delay in humans.

  5. TPPII, MYBBP1A (show MYBBP1A ELISA Kits) and CDK2 (show CDK2 ELISA Kits) form a protein-protein interaction network.

  6. Previously unknown differences between TPP II orthologues and subtilisin as well as features that might be conserved within the entire family of subtilisin-like serine peptidases.

  7. Study showed that overexpression of Tripeptidyl peptidase II (TPP2) occurs frequently during oral carcinogenesis and might be associated with the progression of Oral Squamous Cell Carcinoma (OSCC) via Spindle Assembly Checkpoint(SAC (show ADCY10 ELISA Kits)) activation.

  8. obtained a 3D structure of the human TPPII

  9. Current knowledge about TPPII with a focus on structural aspects.

  10. Results suggest an important function of TPPII in the maintenance of viral growth and may have implications for anti-viral therapy.

Mouse (Murine) Tripeptidyl Peptidase II (Tpp2) interaction partners

  1. Data indicate that TPPII can regulate sperm maturation by modulating intracellular Ca(2 (show CA2 ELISA Kits)+) stores via the type 3 RyR (show RYR1 ELISA Kits).

  2. Previously unknown differences between TPP II orthologues and subtilisin as well as features that might be conserved within the entire family of subtilisin-like serine peptidases.

  3. Tripeptidyl peptidase II is crucial for nucleoprotein epitope generation during major histocompatibility complex class I complex viral antigen processing both in the presence and absence of lactacystin-sensitive proteasome action.

  4. TPPII is not generally required for the production of major histocompatibility class I-restricted peptides, but presentation of some peptides can be negatively affected by TPPII.

  5. Data show that mice that were homozygous for an insertion in the Tpp2 locus were embryonic lethal and Tpp2 heterozygous mutants were lean compared with wild-type littermates, although food intake was normal.

  6. The data suggest a moderate, predominantly destructive role of TPPII in class I Ag processing.

  7. TPPII is important for maintaining normal cellular and systemic physiology, which may be relevant for potential therapeutic applications of TPPII inhibitors

  8. These results do not support a generally important role of TPPII for viability and proliferation of transformed cells or their p53 (show TP53 ELISA Kits)-mediated DNA damage response.

  9. These data indicate that while TPPII contributes to the trimming of peptides with very long N-terminal extensions, TPPII is not essential for generating most MHC class I-presented peptides or for stimulating CTL responses to several Ags (show GLA ELISA Kits) in vivo.

Tpp2 Antigen Profile

Antigen Summary

This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase\; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class.

Gene names and symbols associated with Tpp2

  • tripeptidyl-peptidase II (TppII) antibody
  • tripeptidyl peptidase II (TPP2) antibody
  • tripeptidyl peptidase II (tpp2) antibody
  • tripeptidyl peptidase ii (AaeL_AAEL007174) antibody
  • tripeptidyl peptidase ii (AaeL_AAEL009516) antibody
  • tripeptidyl peptidase ii (AaeL_AAEL010192) antibody
  • tripeptidyl peptidase II (LOC100359134) antibody
  • tripeptidyl peptidase II (Tpp2) antibody
  • anon-WO0118547.127 antibody
  • CG3991 antibody
  • DKFZp468E2313 antibody
  • Dmel\\CG3991 antibody
  • dTPP II antibody
  • dTPPII antibody
  • l(2)k14301 antibody
  • MGC83244 antibody
  • T13K14.10 antibody
  • T13K14_10 antibody
  • TPP-2 antibody
  • TPP2 antibody
  • TPP II antibody
  • TppII antibody
  • tripeptidyl peptidase ii antibody

Protein level used designations for Tpp2

CG3991-PA , CG3991-PD , TppII-PA , TppII-PD , Tripeptidyl-peptidase II , tripeptidyl peptidase II , tripeptidylpeptidase II , tripeptidyl peptidase ii , tripeptidyl-peptidase 2 , TPP-II , tripeptidyl aminopeptidase , tripeptidyl-peptidase II

GENE ID SPECIES
36444 Drosophila melanogaster
428020 Gallus gallus
443806 Xenopus laevis
827833 Arabidopsis thaliana
5568882 Aedes aegypti
5572106 Aedes aegypti
5572975 Aedes aegypti
100101674 Xenopus (Silurana) tropicalis
100172493 Pongo abelii
100359134 Oryctolagus cuniculus
100552517 Anolis carolinensis
7174 Homo sapiens
22019 Mus musculus
81815 Rattus norvegicus
526052 Bos taurus
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