Tropomodulin 1 Proteins (TMOD1)

TMOD1 encodes a member of the tropomodulin family. Additionally we are shipping Tropomodulin 1 Antibodies (64) and Tropomodulin 1 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TMOD1 7111 P28289
TMOD1 21916 P49813
TMOD1 25566  
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Top Tropomodulin 1 Proteins at

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days

TMOD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Tropomodulin 1 (TMOD1) Interaction Partners

Human Tropomodulin 1 (TMOD1) interaction partners

  1. The mutation reduced binding affinity for both Lmod2 (show LMOD2 Proteins) and Tmod1. The effect of the K15N mutation on Tpm1.1 binding to Lmod2 (show LMOD2 Proteins) and Tmod1 provides a molecular rationale for the development of familial dilated cardiomyopathies .

  2. Study highlighted a novel TMOD1-mediated link between NF-kappaB (show NFKB1 Proteins) activation and MMP13 (show MMP13 Proteins) induction, which accounts in part for the NF-kappaB (show NFKB1 Proteins)-dependent malignant phenotype of TNBC.

  3. Tmod1 and Tmod3 (show TMOD3 Proteins) showed somewhat different tropomyosin (show TPM2 Proteins)-binding site utilization.

  4. The structures and biochemical analysis of structure-inspired mutants showed that one Tmod molecule interacts with three actin subunits at the pointed end, while also contacting two tropomyosin (show TPM2 Proteins) molecules on each side of the filament.

  5. Tropomyosin (show TPM2 Proteins) requires an intact N-terminal coiled coil to interact with this protein

  6. levels of TM1 (show TPM2 Proteins), TM2 (show TPM2 Proteins) and TM3 (show TPM1 Proteins) are reduced in human transitional cell carcinoma cells, but significantly upregulated by inhibition of the mitogen-activated protein kinase (show MAPK1 Proteins)-signaling pathway

  7. The N-terminal "KRK ring" may participate in balancing electrostatic force with hydrophobic interaction in dimerization of TM and its binding to E-Tmod.

  8. study identifies several amino acid residues on Tmod-1 that are important for its interaction with TM5 (a nonmuscle TM isoform)

Mouse (Murine) Tropomodulin 1 (TMOD1) interaction partners

  1. distinct F-actin organizations are present in small protrusions versus large paddles. Formation and/or maintenance of large paddle domains depends on a beta2-spectrin-actin network stabilized by Tmod1. alpha-Actinin (show ACTN1 Proteins)-crosslinked F-actin bundles are enhanced in absence of Tmod1, indicating altered cytoskeleton organization.

  2. TMOD1 expression was upregulated significantly (p<0.05) in OSCC.

  3. RNAi depletion of Tmod1 from either wild-type or Tmod4 (show TMOD4 Proteins)(-/-) muscle fibers leads to thin filament elongation by approximately 15%.

  4. The C-terminal extension of Lmod2 (show LMOD2 Proteins) and C terminal of Tmod1 are sufficient to produce a filament nucleator.

  5. Calpain-mediated proteolysis of tropomodulin isoforms TMOD1 and TMOD4 (show TMOD4 Proteins) leads to thin filament elongation in dystrophic skeletal muscle.

  6. Role of Tmod1 protein's leucine rich repeat domain in the formation of neurite-like processes

  7. Tmod1 is involved in a functional synergy critical for regulating lens fiber cell geometry, transparency, and mechanical stiffness.

  8. Tropomodulin 1 constrains fiber cell geometry during elongation and maturation in the lens cortex.

  9. The Tmod1 deletion caused Tmod3 to leave its SR compartment, leading to mislocalization and destabilization of the Tmod3-gamma(cyto)-actin-sAnk1.5 complex.

  10. Tmod1-null mice display a mild anemia with features resembling hereditary spherocytic elliptocytosis.

Tropomodulin 1 (TMOD1) Protein Profile

Protein Summary

This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with Tropomodulin 1 Proteins (TMOD1)

  • tropomodulin 1 (TMOD1)
  • tropomodulin 1 (tmod1)
  • tropomodulin 1 (Tmod1)
  • D9S57E protein
  • E-Tmod protein
  • ETMOD protein
  • si:ch211-288h2.6 protein
  • Tmod protein
  • TMOD1 protein
  • tropomodulin-1 protein

Protein level used designations for Tropomodulin 1 Proteins (TMOD1)

tropomodulin-1 , tropomodulin 1 , tropomodulin-1-like , E-Tmod , e-tropomodulin , erythrocyte tropomodulin , E-Tropomodulin

395883 Gallus gallus
464599 Pan troglodytes
474771 Canis lupus familiaris
715838 Macaca mulatta
100149766 Danio rerio
100316850 Sus scrofa
100397199 Callithrix jacchus
100443166 Pongo abelii
100588809 Nomascus leucogenys
7111 Homo sapiens
21916 Mus musculus
25566 Rattus norvegicus
780784 Bos taurus
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