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Blocks the elongation and depolymerization of the actin filaments at the pointed end. Additionally we are shipping Tropomodulin 4 Antibodies (35) and Tropomodulin 4 Proteins (5) and many more products for this protein.
RNAi depletion of Tmod1 (show TMOD1 ELISA Kits) from either wild-type or Tmod4(-/-) muscle fibers leads to thin filament elongation by approximately 15%.
Calpain-mediated proteolysis of tropomodulin isoforms TMOD1 (show TMOD1 ELISA Kits) and TMOD4 leads to thin filament elongation in dystrophic skeletal muscle.
Tmod4 localizes to thin filament pointed ends in Tmod1 (show TMOD1 ELISA Kits)-null embryonic muscle
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).
, tropomodulin 4
, skeletal muscle tropomodulin
, skeletal tropomodulin
, actin-capping protein