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anti-Tropomyosin 1 (Alpha) (TPM1) Antibodies

TPM1 is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Additionally we are shipping Tropomyosin 1 (Alpha) Proteins (33) and Tropomyosin 1 (Alpha) Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TPM1 7168 P09493
TPM1 22003 P58771
TPM1 24851 P04692
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Top anti-Tropomyosin 1 (Alpha) Antibodies at antibodies-online.com

Showing 10 out of 44 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated IHC, WB WB Suggested Anti-TPM1 Antibody Titration: 1.25ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Chicken Mouse Un-conjugated IHC (fro), IF, IHC (p), IP, WB   0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Chicken Mouse Un-conjugated WB   0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Chicken Mouse Un-conjugated IHC (fro), IF, WB   0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Chicken Mouse Un-conjugated IF, IHC (p) 0.1 mg Log in to see 10 to 12 Days
$519.75
Details
Chicken Mouse Un-conjugated ICC, IF, IP, IHC, MA, ELISA, WB Monoclonal Anti-Tropomyosin (36/39 kDa) antibody produced in mouse 0.1 mL Log in to see 5 to 7 Days
$366.19
Details
Human Rabbit Un-conjugated IHC (p), WB Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 6 to 8 Days
$500.50
Details
Dog Rabbit Un-conjugated IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details

TPM1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Mouse (Murine)
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Rat (Rattus) , ,
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Top referenced anti-Tropomyosin 1 (Alpha) Antibodies

  1. Chicken Monoclonal TPM1 Primary Antibody for IHC (fro), IF - ABIN1109349 : Gunning, ONeill, Hardeman: Tropomyosin-based regulation of the actin cytoskeleton in time and space. in Physiological reviews 2008 (PubMed)
    Show all 3 references for ABIN1109349

  2. Chicken Monoclonal TPM1 Primary Antibody for WB - ABIN1109347 : Gariboldi, Manenti, Dragani, Pierotti: Chromosome mapping of nine tropomyosin-related sequences in mice. in Mammalian genome : official journal of the International Mammalian Genome Society 1995 (PubMed)
    Show all 2 references for ABIN1109347

  3. Chicken Monoclonal TPM1 Primary Antibody for IHC (fro), IF - ABIN1109348 : Lees-Miller, Helfman: The molecular basis for tropomyosin isoform diversity. in BioEssays : news and reviews in molecular, cellular and developmental biology 1992 (PubMed)
    Show all 2 references for ABIN1109348

  4. Dog (Canine) Polyclonal TPM1 Primary Antibody for IHC, WB - ABIN2776783 : Lin, Tarn: Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB. in Molecular and cellular biology 2005 (PubMed)

  5. Chicken Polyclonal TPM1 Primary Antibody for WB - ABIN2776817 : Bos, Theis, Tajik, Gersh, Ommen, Ackerman: Relationship between sex, shape, and substrate in hypertrophic cardiomyopathy. in American heart journal 2008 (PubMed)

More Antibodies against Tropomyosin 1 (Alpha) Interaction Partners

Rabbit Tropomyosin 1 (Alpha) (TPM1) interaction partners

  1. Maximal Ca(2 (show CA2 Antibodies)+) activated force was the same in alphaalphaTm versus betabetaTm myofibrils, but betabetaTm myofibrils showed a marked slowing of relaxation and an impairment of regulation under resting conditions

  2. Tmod1 (show TMOD1 Antibodies) and Tmod3 (show TMOD3 Antibodies) showed somewhat different tropomyosin (show TPM2 Antibodies)-binding site utilization.

  3. Thermal denaturation of rabbit cardiac alpha,alpha-tropomyosin is monitored at neutral pH and compared to shark tropomyosin (show TPM2 Antibodies), showing that amino acid substitutions predicted to be unfavorable in one temperature regime are desirable in another.

  4. The rotational motion of a spin label covalently bound to the side chain of a cysteine genetically incorporated into rabbit skeletal muscle tropomyosin (show TPM2 Antibodies), was measured.

  5. a computational search assessing electrostatic interactions for multiple azimuthal locations, z-positions, and pseudo-rotations of tropomyosin on F-actin was performed.

Human Tropomyosin 1 (Alpha) (TPM1) interaction partners

  1. The TPM1 (rs1071646) and TNNT2 (show TNNT2 Antibodies) (rs3729547) gene variants might represent risk factors for patients with dilated cardiomyopathy in the Kazakh population.

  2. The mutation reduced binding affinity for both Lmod2 (show LMOD2 Antibodies) and Tmod1 (show TMOD1 Antibodies). The effect of the K15N mutation on Tpm1.1 binding to Lmod2 (show LMOD2 Antibodies) and Tmod1 (show TMOD1 Antibodies) provides a molecular rationale for the development of familial dilated cardiomyopathies .

  3. Data confirm that the substitutions of the Tpm1 residues G126 and D137 with the canonical ones, Arg and Leu, respectively, increase the stiffness of the Tpm (show TPMT Antibodies) coiled-coil

  4. these results indicate that TPM1 may be one mechanism underlying radiation resistance, and TPM1 may be a potential target for overcoming the radiation resistance in glioma.

  5. Mitochondrial RNA induces tropomyosin (show TPM2 Antibodies) synthesis.

  6. TPM1 exhibits characteristics of a tumor-suppressor gene while being overexpressed in Renal cell carcinoma (show MOK Antibodies) cell lines.

  7. We have quantified the expression of the total sarcomeric TPM1 and observed a 1.5-fold increase in treated cells.

  8. Coexistence of Digenic Mutations in Both TPM1 and MYH7 (show MYH7 Antibodies) Genes Leads to Severe Hypertrophic Cardiomyopathy.

  9. Mutant TPM1cause m ultiple functional alterations in actin affinity and Ca2 (show CA2 Antibodies)+ sensitivity.

  10. Development of pathological hypertrophy did not occur in mice expressing both Tm180 and TnI (show TNNI2 Antibodies)-PP.

Pig (Porcine) Tropomyosin 1 (Alpha) (TPM1) interaction partners

  1. We show that the phosphorylation of cTnI and alphaTm vary in the different chambers of the heart, whereas the phosphorylation of MLC2 and cTnT does not.

Cow (Bovine) Tropomyosin 1 (Alpha) (TPM1) interaction partners

  1. The tendency of smooth muscle tropomyosin to form semi-rigid polymers with continuous and undampened rigidity may compensate for the lack of troponin-based structural support in smooth muscles.

  2. Deletion of regions 2-3 in tropomyosin (show TPM2 Antibodies) alpha resulted in an 60 % decrease in both isometric tension and stiffness of tropomyosin (show TPM2 Antibodies)-reconstituted myocardium.

  3. Tropomyosin (show TPM2 Antibodies) is primarily responsible for the change in the kinetic constants of the elementary steps of the cross bridge cycle.

  4. Tm affects the conformation of actin so as to increase the area of hydrophobic interaction between actin and myosin molecules

Mouse (Murine) Tropomyosin 1 (Alpha) (TPM1) interaction partners

  1. three-dimensional structure of F-actin at a resolution of 3.7 A in complex with tropomyosin (show TPM2 Antibodies) at a resolution of 6.5 A, determined by electron cryomicroscopy

  2. data also identify a novel alphaTM1/Tmod1 (show TMOD1 Antibodies)-based pathway stabilizing F-actin at cell-cell junctions, which may be required for maintenance of cell shapes during embryonic cardiac morphogenesis (show XIRP1 Antibodies).

  3. This is the first study to demonstrate that decreasing phosphorylation of tropomyosin (show TPM2 Antibodies) can rescue a hypertrophic cardiomyopathic phenotype.

  4. Tropomyosin (show TPM2 Antibodies) dephosphorylation results in myocyte hypertrophy with increases in SERCA2a (show ATP2A2 Antibodies) expression.

  5. The results identify a novel mode of myofilament desensitization to Ca(2 (show CA2 Antibodies)+) associated with a DCM linked switch in TPM1-kappa.

  6. signaling by alpha-tropomyosin may have a role in familial hypertrophic cardiomyopathy

  7. A point mutation in alpha-TM causes a disease similar to familial hypertophic cardiomyopahy.

  8. PTB (show PTBP1 Antibodies) interacting protein raver1 (show RAVER1 Antibodies) regulates alpha-tropomyosin alternative splicing.

  9. the N terminus is a critical determinant of TM1 (show TPM2 Antibodies) functions, which in turn determines the organization of stress fibers.

  10. charge changes at the carboxy-terminal of alpha-TM alter the functional characteristics of the heart at both the whole organ and myofilament levels.

Tropomyosin 1 (Alpha) (TPM1) Antigen Profile

Protein Summary

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.

Gene names and symbols associated with TPM1

  • alpha-tropomyosin (LOC100125989) antibody
  • alpha-tropomyosin (tpma) antibody
  • tropomyosin (tm7) antibody
  • tropomyosin (Smp_044010.2) antibody
  • tropomyosin 1 (LOC732984) antibody
  • tropomyosin 1 (alpha) (TPM1) antibody
  • tropomyosin 1 (alpha) (tpm1) antibody
  • tropomyosin 1, alpha (Tpm1) antibody
  • AA986836 antibody
  • AI854628 antibody
  • alpha-fTM antibody
  • Alpha-tm antibody
  • alpha-tropomyosin antibody
  • C15orf13 antibody
  • CH1 antibody
  • CMD1Y antibody
  • CMH3 antibody
  • fb37a09 antibody
  • HTM-alpha antibody
  • MGC84844 antibody
  • tm antibody
  • TM2 antibody
  • Tm3 antibody
  • Tm7 antibody
  • Tma2 antibody
  • Tmpa antibody
  • Tmsa antibody
  • Tpm-1 antibody
  • tpm1 antibody
  • TPMA antibody
  • wu:fb37a09 antibody

Protein level used designations for TPM1

tropomyosin alpha-1 chain , tropomyosin , Tropomyosin-1 alpha chain , tropomyosin-1 , alpha-tropomyosin 1 , alpha-tropomyosin 2 , alpha-tropomyosin of skeletal fast muscle , tropomyosin (CTm4) , tropomyosin (CTm7) , alpha-tropomyosin , cardiomyopathy, hypertrophic 3 , sarcomeric tropomyosin kappa , tropomyosin 1 (alpha) isoform 1 , tropomyosin 1 (alpha) isoform 2 , tropomyosin 1 (alpha) isoform 3 , tropomyosin 1 (alpha) isoform 4 , tropomyosin 1 (alpha) isoform 5 , tropomyosin 1 (alpha) isoform 6 , tropomyosin 1 (alpha) isoform 7 , tropomyosin 1 alpha chain , alpha-skeletal tropomyosin , alpha tropomyosin , hepatoma alpha tropomyosin , smooth muscle alpha-tropomyosin , striated muscle alpha-tropomyosin , tropomyosin 3 alpha

GENE ID SPECIES
100125989 Oryctolagus cuniculus
30324 Danio rerio
431788 Xenopus laevis
8350314 Schistosoma mansoni
732984 Bombyx mori
396366 Gallus gallus
7168 Homo sapiens
100037999 Sus scrofa
281544 Bos taurus
100189579 Xenopus laevis
478332 Canis lupus familiaris
22003 Mus musculus
24851 Rattus norvegicus
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