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Tropomyosin 3 Proteins (TPM3)

TPM3 encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Additionally we are shipping TPM3 Antibodies (29) and TPM3 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TPM3 7170 P06753
Rat TPM3 TPM3 117557 Q63610
TPM3 59069 P21107
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Top TPM3 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,746.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,746.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$382.86
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 5 Days
$385.00
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 10 to 12 Days
$447.48
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

TPM3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced TPM3 Proteins

  1. Human TPM3 Protein expressed in Escherichia coli (E. coli) - ABIN667651 : Ohtsuki, Shiraishi: Periodic binding of troponin C.I and troponin I to tropomyosin-actin filaments. in Journal of biochemistry 2002 (PubMed)
    Show all 2 references for ABIN667651

  2. Human TPM3 Protein expressed in Wheat germ - ABIN1323437 : van Helmond, Heesom, Love: Characterisation of two antibodies to oligomeric Abeta and their use in ELISAs on human brain tissue homogenates. in Journal of neuroscience methods 2008 (PubMed)

More Proteins for Tropomyosin 3 (TPM3) Interaction Partners

Human Tropomyosin 3 (TPM3) interaction partners

  1. Dominant mutations in TPM3, encoding alpha-tropomyosinslow, cause a congenital myopathy characterized by generalized muscle weakness. Here, we used a multidisciplinary approach to investigate the mechanism of muscle dysfunction in 12 TPM3-myopathy patients.

  2. This work expands the phenotypic spectrum of TPM3-related disease and provides insights into the pathophysiological mechanisms of the actin-tropomyosin (show TPM2 Proteins) complex

  3. Western blot showed phosphorylation of ALK, ERK1/2, and STAT3 (show STAT3 Proteins) in cells transfected with TPM3-ALK. Coiled-coil structure of TPM3 contributes to the transforming ability of the TPM3-ALK fusion protein, and longer TPM3 region leads to higher dimer formation.

  4. Patients with TPM2 (show TPM2 Proteins) mutations tended to present with milder symptoms than those with TPM3 mutations, DA being present only in the TPM2 (show TPM2 Proteins) group.

  5. in a cohort of 94 patients with congenital myopathy, 2 related female patients and 2 sporadic male patients were found to carry mutations in TPM2 (show TPM2 Proteins) and TPM3 genes respectively; clinical presentation and muscle morphological findings differed in the patients

  6. DATA show that tropomyosin 3 protein (TPM3) plays a critical role in the progression of gliomas.

  7. study reports on a three-generation family with cap myopathy caused by a novel heterozygous mutation in TPM3

  8. In addition to CLIC1 (show CLIC1 Proteins) and TPM1 (show TPM1 Proteins), which were the proteins initially discovered in a xenograft mouse model, CLIC4 (show CLIC4 Proteins), TPM2 (show TPM2 Proteins), TPM3, and TPM4 (show TPM4 Proteins) were present in ovarian cancer patient sera at significantly elevated levels compared with controls.

  9. TPM3-R167H mutations decreased cooperative thin filament activation in combination with reductions in the myosin cross-bridge number and force production.

  10. TPM3 is an interacting partner of granulin-epithelin (show GRN Proteins) precursor and may play an important role in hepatocarcinogenesis.

Mouse (Murine) Tropomyosin 3 (TPM3) interaction partners

  1. Tpm3 plays crucial roles in maintaining cortical actin integrity and asymmetric cell division during oocyte maturation, and that dynamic regulation of cortical actin by Tpm3 is critical to ensure proper polar body protrusion.

  2. TMBr-3 and TM5NM1 modestly affected actin assembly kinetics, in an opposite manner.

  3. Tropomyosin (show TPM2 Proteins) regulates cell migration during skin wound healing.

  4. Data conclude that exon 9d-containing isoforms are not essential for survival of neuronal cells and that isoform choice from the gamma-Tm gene is flexible in the brain

  5. Reduced expression of Tpm3, sarcomere genes and Lrtm1 in the diaphragm of mice with diaphragmatic defects.

  6. Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2 (show CA2 Proteins)+) activation.

  7. tropomyosin (show TPM2 Proteins) isoforms regulate neuronal size and shape

  8. results indicate that a Tm5NM1-defined actin cytoskeleton is required for the normal excitation-contraction coupling in skeletal muscle

TPM3 Protein Profile

Protein Summary

This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Tropomyosin 3 Proteins (TPM3)

  • tropomyosin 3 (TPM3)
  • tropomyosin 3 (tpm3)
  • tropomyosin 3 (Tpm3)
  • tropomyosin 3, gamma (Tpm3)
  • CAPM1 protein
  • cb674 protein
  • CFTD protein
  • fa17b11 protein
  • fb83b01 protein
  • fk41e01 protein
  • gamma-TM protein
  • hm:zeh0298 protein
  • hscp30 protein
  • hTM30nm protein
  • hTMnm protein
  • NEM1 protein
  • OK/SW-cl.5 protein
  • TM-5 protein
  • TM3 protein
  • TM5 protein
  • Tm5NM protein
  • TM30 protein
  • TM30nm protein
  • Tpm-5 protein
  • TPM3 protein
  • Tpm5 protein
  • TPMsk3 protein
  • TRK protein
  • Trop-5 protein
  • wu:fa17b11 protein
  • wu:fb83b01 protein
  • wu:fk41e01 protein
  • zeh0298 protein
  • zgc:77592 protein

Protein level used designations for Tropomyosin 3 Proteins (TPM3)

tropomyosin 3 , tropomyosin alpha-3 chain , alpha-tropomyosin, slow skeletal , cytoskeletal tropomyosin TM30 , heat-stable cytoskeletal protein 30 kDa , tropomyosin gamma , tropomyosin-5 , gamma-tropomyosin , tropomyosin-3 , nonmuscle tropomyosin 5 , tropomyosin 3, gamma , tropomyosin non-muscle , skalphaTM.2 , tropomyosin 5

GENE ID SPECIES
458000 Pan troglodytes
480137 Canis lupus familiaris
484695 Canis lupus familiaris
100174017 Pongo abelii
373076 Danio rerio
7170 Homo sapiens
497019 Bos taurus
117557 Rattus norvegicus
414388 Sus scrofa
59069 Mus musculus
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