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Tropomyosin-2 Proteins (TPM2)

TPM2 encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Additionally we are shipping Tropomyosin-2 Antibodies (71) and Tropomyosin-2 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TPM2 7169 P07951
TPM2 22004 P58774
TPM2 500450 P58775
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Top Tropomyosin-2 Proteins at

Showing 10 out of 23 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 7 to 8 Days
HOST_Escherichia coli (E. coli) Human His tag Tropomyosin-2 (TPM2) (AA 14-284), (partial) protein (His tag) 50 μg Log in to see 9 to 11 Days
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Yeast His tag   1 mg Log in to see 56 to 66 Days
Yeast Hydrozoa His tag   1 mg Log in to see 56 to 66 Days
Yeast Schistosoma mansoni His tag   1 mg Log in to see 56 to 66 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days

TPM2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
Mouse (Murine)

Rat (Rattus)

Top referenced Tropomyosin-2 Proteins

  1. Human TPM2 Protein expressed in Escherichia coli (E. coli) - ABIN667325 : Hunt, Eyre, Akkari, Meredith, Dorosz, Wilton, Callen, Laing, Baker: Assignment of the human beta tropomyosin gene (TPM2) to band 9p13 by fluorescence in situ hybridisation. in Cytogenetics and cell genetics 1995 (PubMed)
    Show all 2 references for ABIN667325

More Proteins for Tropomyosin-2 (TPM2) Interaction Partners

Fruit Fly (Drosophila melanogaster) Tropomyosin-2 (TPM2) interaction partners

  1. Tropomyosin2 dictates fundamental steps of myogenesis prior to regulating contraction in the sarcomere.

Human Tropomyosin-2 (TPM2) interaction partners

  1. Despite its reduced affinity for actin in co-sedimentation assay, the Q147P mutant incorporates into the muscle fiber ..Q147P tropomyosin (TPM2)binds to actin in ghost muscle fiber.

  2. tropomyosin 2.1 acts as a suppressor of growth on soft matrices by supporting proper rigidity sensing

  3. Myo1c (show MYO1C Proteins) significantly increases the frequency of kinesin-1-driven microtubule-based runs that begin at actin/microtubule intersections. The actin-binding protein (show KPTN Proteins) tropomyosin 2 abolishes Myo1c (show MYO1C Proteins)-specific effects on both run initiation and run termination.

  4. Changes for CRMP2 (show DPYSL2 Proteins), TCP1epsilon, TPM2 and 14-3-3gamma (show YWHAG Proteins) were confirmed in experimental tumors and in a series of 28 human SI-NETs.

  5. Patients with TPM2 mutations tended to present with milder symptoms than those with TPM3 (show TPM3 Proteins) mutations, DA being present only in the TPM2 group.

  6. in a cohort of 94 patients with congenital myopathy, 2 related female patients and 2 sporadic male patients were found to carry mutations in TPM2 and TPM3 (show TPM3 Proteins) genes respectively; clinical presentation and muscle morphological findings differed in the patients

  7. Histopathological phenotype association of muscle fibers expressing Beta-tropomyosin mutational variants that occur in human myopathies.

  8. effect of the skeletal myopathy-causing E117K mutation in human beta-tropomyosin on actomyosin structure during the ATPase cycle

  9. In addition to CLIC1 (show CLIC1 Proteins) and TPM1 (show TPM1 Proteins), which were the proteins initially discovered in a xenograft mouse model, CLIC4 (show CLIC4 Proteins), TPM2, TPM3 (show TPM3 Proteins), and TPM4 (show TPM4 Proteins) were present in ovarian cancer patient sera at significantly elevated levels compared with controls.

  10. We showed that TPM2, CLU (show CLU Proteins), and COL4A6 (show COL4a6 Proteins) mRNA levels are downregulated in prostate cancer.

Mouse (Murine) Tropomyosin-2 (TPM2) interaction partners

  1. Trop-2 (show TACSTD2 Proteins) promotes an alpha5beta1 integrin-dependent pro-metastatic signaling pathway in PCa (show ENPP1 Proteins) cells and that the altered expression of Trop-2 (show TACSTD2 Proteins) may be utilized for early identification of capsule-invading PCa (show ENPP1 Proteins).

  2. our findings help to establish a close functional link between Trop2 (show TACSTD2 Proteins) and MSCs, and to provide a tool for future investigation of Trop2 (show TACSTD2 Proteins) in other types of stem cells

  3. data suggest that Trop2 (show TACSTD2 Proteins) regulates cell proliferation and motility and that it does so by regulating the ERK (show EPHB2 Proteins) pathway and several critical components of the cell migration apparatus

  4. Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction.

  5. Generated chimeric alpha-/beta-tropomyosin protein to alter pathological consequences in mouse model of familial hypertrophic cardiomyopathy.

  6. Tm-2 (show TPM1 Proteins) is up-regulated during osteoclastogenesis, indicating potential cell-specific functions.

  7. Differential expression of RhoGDI-1, cofilin 1 and tropomyosin 2 in calpain-deficient fibroblasts compared with wild-type fibroblasts

Tropomyosin-2 (TPM2) Protein Profile

Protein Summary

This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Tropomyosin-2 Proteins (TPM2)

  • Tropomyosin 2 (Tm2)
  • Tropomyosin-2 (EDI_309330)
  • tropomyosin (LOC100101174)
  • tropomyosin 2 (beta) (tpm2)
  • tropomyosin 2 (beta) (tpm2-a)
  • tropomyosin 2 (beta) (TPM2)
  • tropomyosin 2, beta (Tpm2)
  • AMCD1 protein
  • BRT-2 protein
  • cb836 protein
  • CG4843 protein
  • DA1 protein
  • DA2B protein
  • Dmel\\CG4843 protein
  • dro Tm protein
  • DROTROPI1 protein
  • fb68h02 protein
  • Ifm(3)3 protein
  • Ifm(3)5 protein
  • Ifm-TmI protein
  • l(3)nc99Eb protein
  • mTmI protein
  • NEM4 protein
  • Tm protein
  • Tm1 protein
  • TM2 protein
  • Tm127 protein
  • TmI protein
  • TmII protein
  • TMSB protein
  • Tn-H protein
  • Tpm-2 protein
  • tpm2 protein
  • tpm2a protein
  • TPM3 protein
  • tpm4l protein
  • Trop-2 protein
  • wu:fb68h02 protein
  • wu:fj63f03 protein
  • zgc:86810 protein

Protein level used designations for Tropomyosin-2 Proteins (TPM2)

CG4843-PA , CG4843-PB , CG4843-PC , CG4843-PE , CG4843-PF , Tm2-PA , Tm2-PB , Tm2-PC , Tm2-PE , Tm2-PF , Tropomyosin-2 , lethal(3)nc99Eb , tropomyosin , tropomyosin 127 , tropomyosin 2 , tropomyosin I , tropomyosin2 , actotropomyosin , tropomyosin-2 , fj63f03 , tropomyosin beta chain , fast skeletal muscle beta-tropomyosin 2 , tropomyosin 2 a , tropomyosin 2 a (beta) , beta tropomyosin , beta-tropomyosin , tropomyosin 3 , nemaline myopathy type 4

41853 Drosophila melanogaster
5883196 Entamoeba dispar SAW760
100101174 Bombyx mori
415209 Danio rerio
100335131 Xenopus laevis
396430 Gallus gallus
7169 Homo sapiens
481598 Canis lupus familiaris
497015 Bos taurus
22004 Mus musculus
500450 Rattus norvegicus
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