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Troponin I Type 1 (Skeletal, Slow) Proteins (TNNI1)

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Additionally we are shipping TNNI1 Antibodies (56) and TNNI1 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNNI1 7135 P19237
TNNI1 29388 P13413
TNNI1 21952 Q9WUZ5
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Top TNNI1 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,436.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,445.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$413.21
Details

TNNI1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

Mouse (Murine)

Top referenced TNNI1 Proteins

  1. Human TNNI1 Protein expressed in Escherichia coli (E. coli) - ABIN1098698 : Corin, Juhasz, Zhu, Conley, Kedes, Wade: Structure and expression of the human slow twitch skeletal muscle troponin I gene. in The Journal of biological chemistry 1994 (PubMed)
    Show all 2 references for ABIN1098698

More Proteins for Troponin I Type 1 (Skeletal, Slow) (TNNI1) Interaction Partners

Human Troponin I Type 1 (Skeletal, Slow) (TNNI1) interaction partners

  1. TNNI3K (show TNNI3K Proteins) is a cardiac-specific gene, encoding a cardiac troponin I (show TNNI3 Proteins)-interacting MAP kinase (show MAPK1 Proteins). In mice, Tnni3k (show TNNI3K Proteins) is shown to play an important role in the regulation of cardiac differentiation and cardiac contractility

  2. Data suggest that mutation A162H in switch region of troponin I induces transitory curved conformation and promotes contraction of troponin I bound to regulatory domain of troponin C; this is countered by residue E164 to ensure proper relaxation.

  3. Elevations of troponin I and N-terminal pro-B-type natriuretic peptide (show BNP Proteins) (NT-proBNP) are common in patients with atrial fibrillation and independently related to increased risks of stroke and mortality.

  4. Elevated post-operative troponin 1 levels predict long-term mortality in older patients undergoing emergency orthpedic surgery.

  5. troponin I phosphorylation has a role in protein kinase C-mediated enhanced contractile performance of myocytes

  6. MEF2 (show MEF2A Proteins) activation of the troponin I slow enhancer is repressed by hMusTRD1alpha1 (show GTF2IRD1 Proteins)

  7. Low expression of ssTnI was found in 60% of patients in sinus rhythm or paroxysmal AF and in 8% of patients with chronic AF. Relative ssTnI mRNA expression was significantly lower in patients with AF than in those in sinus rhythm.

  8. A biological marker of myocardial injury, but may also be increased after a grand mal (show MAL Proteins) seizure.

  9. These results suggest that this R21C mutation in TnI affects the Ca(2+)-sensitizing effect of Tn, the ability of TnI to be readily phosphorylated by PKA and the stability of TnI to calpain.

  10. Relationship between myocardial injury, assessed by cardiac troponin I (cTnI) levels, and outcome in selected critically ill patients without acute coronary syndromes or cardiac dysfunction

Pig (Porcine) Troponin I Type 1 (Skeletal, Slow) (TNNI1) interaction partners

  1. analysis of expression profiling of porcine troponin I family in three different types of muscles during development

  2. Two novel single nucleotide polymorphisms (EU743939:g.5174T>C in intron 4 and EU743939:g.8350C>A in intron 7) in TNNI1 and one SNP (EU696779:g.1167C>T in intron 3) in TNNI2 (show TNNI2 Proteins) were identified.

Mouse (Murine) Troponin I Type 1 (Skeletal, Slow) (TNNI1) interaction partners

  1. data demonstrate that thyroid hormone (show PTH Proteins) can alter the time course of ssTnI gene expression in cultured cardiac myocytes and TnI (show TNNI2 Proteins) gene regulation is also controlled by some unknown programmed events inside of cardiac myocytes

  2. a localized N-terminal region of TnI comprised of amino acids 33-80, which interacts with C-terminal regions of cTnC and cTnT, is of particular significance in transducing signaling of thin filament activation by strong cross-bridges

  3. K+-depolarization increased Tnni1 and Acta1 (show ACTA1 Proteins) mRNA levels in both differentiated C2C12 and rat skeletal muscle cells in primary culture

  4. the up-stream domain ( approximately 1,800 bp) of mouse fetal TnI (show TNNI2 Proteins) gene is been cloned and characterized

  5. Phosphorylation of troponin I was significantly reduced in Galphaq (show GNAQ Proteins)-overexpressing mice compared to wild type.

TNNI1 Protein Profile

Protein Summary

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit\; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.

Gene names and symbols associated with TNNI1

  • troponin I type 1 (skeletal, slow) (TNNI1)
  • troponin I type 1 (skeletal, slow) (Tnni1)
  • troponin I type 1 (skeletal, slow) (tnni1)
  • troponin I, skeletal, slow 1 (Tnni1)
  • troponin I, skeletal, slow like (tnni1al)
  • 2700018B22Rik protein
  • AI747285 protein
  • ssTnI protein
  • TnI-S4 protein
  • TNN1 protein
  • troponin 1 protein
  • zgc:86895 protein

Protein level used designations for TNNI1

troponin I, slow skeletal muscle , troponin I, slow-twitch isoform , Troponin I, slow isoform , troponin I, skeletal, slow 1 , TnnI1

GENE ID SPECIES
7135 Homo sapiens
396947 Sus scrofa
29388 Rattus norvegicus
100037198 Xenopus laevis
421161 Gallus gallus
21952 Mus musculus
415191 Danio rerio
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