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Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Additionally we are shipping TNNI1 Antibodies (116) and TNNI1 Kits (25) and many more products for this protein.
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Human TNNI1 Protein expressed in Escherichia coli (E. coli) - ABIN1098698
Corin, Juhasz, Zhu, Conley, Kedes, Wade: Structure and expression of the human slow twitch skeletal muscle troponin I gene. in The Journal of biological chemistry 1994
Show all 2 references for ABIN1098698
GDF-15 (show GDF15 Proteins), sST2 (show SSTR2 Proteins), and hs-TnI (show TNNI2 Proteins) are associated with incident cardiovascular disease and heart failure
CT-1 (show CTF1 Proteins) was found to be associated with Tn-I, which is used to detect myocardial damage after OPCAB surgery. CT-1 (show CTF1 Proteins) may also be used to detect myocardial damage.
TNNI3K (show TNNI3K Proteins) is a cardiac-specific gene, encoding a cardiac troponin I (show TNNI3 Proteins)-interacting MAP kinase (show MAPK1 Proteins). In mice, Tnni3k (show TNNI3K Proteins) is shown to play an important role in the regulation of cardiac differentiation and cardiac contractility
Data suggest that mutation A162H in switch region of troponin I induces transitory curved conformation and promotes contraction of troponin I bound to regulatory domain of troponin C; this is countered by residue E164 to ensure proper relaxation.
Elevations of troponin I and N-terminal pro-B-type natriuretic peptide (show BNP Proteins) (NT-proBNP) are common in patients with atrial fibrillation and independently related to increased risks of stroke and mortality.
Elevated post-operative troponin 1 levels predict long-term mortality in older patients undergoing emergency orthpedic surgery.
troponin I phosphorylation has a role in protein kinase C-mediated enhanced contractile performance of myocytes
MEF2 (show MEF2A Proteins) activation of the troponin I slow enhancer is repressed by hMusTRD1alpha1 (show GTF2IRD1 Proteins)
Low expression of ssTnI was found in 60% of patients in sinus rhythm or paroxysmal AF and in 8% of patients with chronic AF. Relative ssTnI mRNA expression was significantly lower in patients with AF than in those in sinus rhythm.
A biological marker of myocardial injury, but may also be increased after a grand mal (show MAL Proteins) seizure.
analysis of expression profiling of porcine troponin I family in three different types of muscles during development
Two novel single nucleotide polymorphisms (EU743939:g.5174T>C in intron 4 and EU743939:g.8350C>A in intron 7) in TNNI1 and one SNP (EU696779:g.1167C>T in intron 3) in TNNI2 (show TNNI2 Proteins) were identified.
data demonstrate that thyroid hormone (show PTH Proteins) can alter the time course of ssTnI gene expression in cultured cardiac myocytes and TnI (show TNNI2 Proteins) gene regulation is also controlled by some unknown programmed events inside of cardiac myocytes
a localized N-terminal region of TnI comprised of amino acids 33-80, which interacts with C-terminal regions of cTnC and cTnT, is of particular significance in transducing signaling of thin filament activation by strong cross-bridges
K+-depolarization increased Tnni1 and Acta1 (show ACTA1 Proteins) mRNA levels in both differentiated C2C12 and rat skeletal muscle cells in primary culture
the up-stream domain ( approximately 1,800 bp) of mouse fetal TnI (show TNNI2 Proteins) gene is been cloned and characterized
Phosphorylation of troponin I was significantly reduced in Galphaq (show GNAQ Proteins)-overexpressing mice compared to wild type.
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit\; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.
troponin I, slow skeletal muscle
, troponin I, slow-twitch isoform
, Troponin I, slow isoform
, troponin I, skeletal, slow 1