Troponin I Type 3 (Cardiac) Proteins (TNNI3)

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. Additionally we are shipping Troponin I Type 3 (Cardiac) Antibodies (980) and Troponin I Type 3 (Cardiac) Kits (113) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNNI3 7137 P19429
TNNI3 21954 P48787
TNNI3 29248 P23693
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Top Troponin I Type 3 (Cardiac) Proteins at antibodies-online.com

Showing 10 out of 34 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$640.00
Details
Escherichia coli (E. coli) Human GST tag Troponin I Type 3 (Cardiac) (TNNI3) (AA 1-146), (partial) protein (GST tag) 1 mg Log in to see 60 to 71 Days
$1,842.50
Details
Escherichia coli (E. coli) Human His tag   50 μg Log in to see 11 Days
$313.50
Details
Baculovirus infected Insect Cells Human His tag   50 μg Log in to see 2 to 3 Days
$1,353.00
Details
Insect cells (Sf9) Human DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$460.85
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
Details
Human Human Un-conjugated   100 μg Log in to see 8 to 10 Days
$699.60
Details

TNNI3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , , ,
Mouse (Murine)

Rat (Rattus) ,

More Proteins for Troponin I Type 3 (Cardiac) (TNNI3) Interaction Partners

Human Troponin I Type 3 (Cardiac) (TNNI3) interaction partners

  1. In clinical stable patients without known cardiovascular disease, a thorough chest-pain history in combination with hs-TnI (show TNNI2 Proteins) testing can identify a significant low-risk group.

  2. Study showed that in patients who underwent liver transplantation elevation of preoperative high-sensitivity cardiac troponin I level was associated with 1-year mortality and 30-day mortality.

  3. Serial measurement of troponin I revealed a persistent elevation in patients with diabetes mellitus type 2.

  4. Plasma troponin C1 (cTnI) is biomarker of choice for diagnosing acute myocardial infarction (AMI (show CFD Proteins)) because of its high specificity as biomarker for damage to myocardial tissue. Data suggest the "best cut-off" for plasma cTnI is 0.014 micrograms/L in AMI (show CFD Proteins). These studies were conducted in emergency department of a university hospital in Italy using point-of-care testing in patients presenting with chest pain, ages 18-101.

  5. NT-proBNP and hs-cTnI levels were higher in systemic sclerosis patients than controls. Both NT-proBNP and hs-cTnI were associated with the presence of echocardiographic abnormalities.

  6. value of cTnI level assessed 24 hours post-surgery was a reliable predictor of death following liver transplantation with optimal cut-off value of 0.215 ng/mL. The surgery time was the most important predictor of cTnI elevation.

  7. cTnI levels are common in Fabry disease patients, reflecting cardiac involvement.

  8. Report novel troponin I rule-out value below the upper reference limit for acute myocardial infarction.

  9. cTnI determined in hemodynamically stable patients with suspected AMI and wide QRS complex using optimized diagnostic thresholds improves rule-in and rule-out with respect to presence of a significant obstructive CAD

  10. 83 preterm infants with Bronchopulmonary dysplasia born <28-wk gestation and still inpatients at 36-wk corrected age received an echocardiogram and blood tests of B-type natriuretic peptide (BNP (show BNP Proteins)), troponin I, and YKL-40 (show CHI3L1 Proteins).

Mouse (Murine) Troponin I Type 3 (Cardiac) (TNNI3) interaction partners

  1. Hyperphosphorylation of this serine199 in cTnI C terminus impacts heart function by depressing diastolic function at baseline and limiting systolic reserve under physiological stresses. Paradoxically, it preserves heart function after ischemia/reperfusion injury, potentially by decreasing proteolysis of cTnI.

  2. The contributions of cardiac myosin binding protein C and troponin I phosphorylation to beta-adrenergic enhancement of in vivo cardiac function

  3. The difference in myosin regulatory light chain phosphorylation between the ventricles of R21C(+/+) in cardiac troponin I mice likely contributes to observed differences in contractile force and the lower tension monitored in the LV of HCM mice

  4. troponin I phosphorylation specifically alters the Ca(2 (show CA2 Proteins)+) sensitivity of isometric tension and the time course of relaxation in cardiac muscle myofibrils

  5. Combined troponin I Ser (show SIGLEC1 Proteins)-150 and Ser (show SIGLEC1 Proteins)-23/24 phosphorylation sustains thin filament Ca(2 (show CA2 Proteins)+) sensitivity playing an adaptive role to preserve contraction during acidic ischemia.

  6. these results indicate that the inability to enhance myofilament relaxation through cTnI phosphorylation predisposes the heart to abnormal diastolic function, reduced accessibility of cardiac reserves, dysautonomia, and hypertrophy.

  7. Dominant negative TnI-TnT interface mutation decreases the binding affinity of cTnI for TnT, causes early ventricular remodeling, and blunts the beta-adrenergic response of cardiac myocytes.

  8. R193H and R205H mutation increase the binding affinity of Troponin I for Troponin T and Troponin C.

  9. Conclude that dilated cardiomyopathy-causing mutations in thin filament proteins abolish the relationship between myofilament Ca(2+) sensitivity and troponin I phosphorylation by PKA.

  10. The pattern of cTnI post-translational modification depends on sex and hypertrophic cardiomyopathy genotype.

Cow (Bovine) Troponin I Type 3 (Cardiac) (TNNI3) interaction partners

  1. An Ala8Val mutation enhances the effect of cardiac troponin I pseudophosphorylation on the rate of dissociation of calcium from reconstituted thin filaments.

  2. Serum cardiac troponin I cannot be used to distinguish cattle with pericarditis from cattle with other primary cardiac diseases or noncardiac, intrathoracic disorders.

Horse (Equine) Troponin I Type 3 (Cardiac) (TNNI3) interaction partners

  1. Cardiac ANP was increased in horses with mitral regurgitation (MR) and cardiac troponin levels were low in healthy and MR affected horses.

Pig (Porcine) Troponin I Type 3 (Cardiac) (TNNI3) interaction partners

  1. We show that the phosphorylation of cTnI and alphaTm vary in the different chambers of the heart, whereas the phosphorylation of MLC2 and cTnT does not.

  2. hFABP (show FABP3 Proteins) rises faster and correlates better with infarct size and no-reflow than hsTnI in myocardial infarction + reperfusion when measured early after reperfusion.

  3. analysis of expression profiling of porcine troponin I family in three different types of muscles during development

Rainbow Trout (Oncorhynchus mykiss) Troponin I Type 3 (Cardiac) (TNNI3) interaction partners

  1. By replacing rat cardiac troponin I (cTnI) in a mammalian cTn complex with trout cTnI it was demonstrated that this protein increases the Ca2+ affinity and reduces the influence of PKA phosphorylation on the Ca2+ affinity of the cTn complex.

Troponin I Type 3 (Cardiac) (TNNI3) Protein Profile

Protein Summary

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit\; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

Gene names and symbols associated with TNNI3

  • troponin I3, cardiac type (TNNI3)
  • troponin I, cardiac 3 (Tnni3)
  • troponin I type 3 (cardiac) (TNNI3)
  • troponin I3, cardiac type S homeolog (tnni3.S)
  • troponin I3, cardiac type L homeolog (tnni3.L)
  • troponin I3, cardiac type (tnni3)
  • cardiac troponin I (LOC100462680)
  • troponin I3, cardiac type (Tnni3)
  • c-troponin protein
  • CMD1FF protein
  • CMD2A protein
  • cmh7 protein
  • cTNI protein
  • ctnIc protein
  • cTNT protein
  • RCM1 protein
  • Tn1 protein
  • TnI protein
  • TnIc protein
  • tnnc1 protein
  • TNNI3 protein
  • XTnIc protein

Protein level used designations for TNNI3

troponin I, cardiac muscle , cardiac troponin I , troponin IC , troponin I type 3 (cardiac) , cardiac tropin T , troponin I, cardiac , troponin 1, type 3

GENE ID SPECIES
7137 Homo sapiens
21954 Mus musculus
396428 Gallus gallus
397803 Xenopus laevis
403566 Canis lupus familiaris
494826 Xenopus laevis
496889 Xenopus (Silurana) tropicalis
511094 Bos taurus
100034065 Equus caballus
100049696 Sus scrofa
100462680 Oncorhynchus mykiss
698470 Macaca mulatta
29248 Rattus norvegicus
493744 Felis catus
101121961 Ovis aries
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