anti-Tu Translation Elongation Factor, Mitochondrial (Tufm) Antibodies

Tufm encodes a protein which participates in protein translation in mitochondria. Additionally we are shipping Tu Translation Elongation Factor, Mitochondrial Proteins (26) and Tu Translation Elongation Factor, Mitochondrial Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Tufm 7284 P49411
Tufm 233870 Q8BFR5
Tufm 293481 P85834
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Top anti-Tu Translation Elongation Factor, Mitochondrial Antibodies at antibodies-online.com

Showing 10 out of 67 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-TUFM Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using TUFM Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of TUFM Antibody (N-term) (ABIN389459) in Ramos, Hela cell line lysates (35 µg/lane). TUFM (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with TUFM Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of TUFM Antibody (N-term) in Ramos cell line lysates (35ug/lane). TUFM (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of TUFM (arrow) using rabbit polyclonal TUFM Antibody (C-term) . 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the TUFM gene. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ICC, IF, IP, IHC (p), WB IP Image TUFM antibody immunoprecipitates TUFM protein in IP experiments. IP samples: HepG2 whole cell extract A. 35 μg HepG2 whole cell extract B. Control with 4 μg of preimmune Rabbit IgG C. Immunoprecipitation of TUFM protein by 4 μg TUFM antibody , 10 % SDS-PAGE The immunoprecipitated TUFM protein was detected by TUFM antibody , diluted at 1:1000. [EasyBlot anti-rabbit IgG  was used as a secondary reagent] WB Image Sample (30 ug of whole cell lysate) A:NIH-3T3 10% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 1 to 2 Days
$358.60
Details
Dog Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated WB Western blot analysis of TUFM (arrow) using rabbit polyclonal TUFM Antibody (C-term) (ABIN656840). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the TUFM gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IP, IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded SNU16 xenograft, using TUFM, antibody at 1:100 dilution. IP Image TUFM antibody [N3C3] immunoprecipitates TUFM protein in IP experiments. IP samples: HepG2 whole cell extract A. 35 μg HepG2 whole cell extract B. Control with 4 μg of preimmune Rabbit IgG C. Immunoprecipitation of TUFM protein by 4 μg TUFM antibody [N3C3] , 10 % SDS-PAGE The immunoprecipitated TUFM protein was detected by TUFM antibody [N3C3] , diluted at 1:1000. [EasyBlot anti-rabbit IgG  was used as a secondary reagent] 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged TUFM is approximately 0.3ng/ml as a capture antibody. 100 μg Log in to see 11 to 12 Days
$430.00
Details

Tufm Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Tu Translation Elongation Factor, Mitochondrial Antibodies

  1. Human Polyclonal Tufm Primary Antibody for IF, WB - ABIN521152 : He, Cooper, Reyes, Di Re, Kazak, Wood, Mao, Fearnley, Walker, Holt: Human C4orf14 interacts with the mitochondrial nucleoid and is involved in the biogenesis of the small mitochondrial ribosomal subunit. in Nucleic acids research 2012 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal Tufm Primary Antibody for ICC, IF - ABIN4363539 : Lundberg, Fagerberg, Klevebring, Matic, Geiger, Cox, Algenäs, Lundeberg, Mann, Uhlen: Defining the transcriptome and proteome in three functionally different human cell lines. in Molecular systems biology 2010 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal Tufm Primary Antibody for ELISA - ABIN563293 : Tomaino, Cappello, Capello, Fredolini, Ponzetto, Novarino, Ciuffreda, Bertetto, De Angelis, Gaia, Salacone, Milella, Nisticò, Alessio, Chiarle, Giuffrida, Giovarelli, Novelli: Autoantibody signature in human ductal pancreatic adenocarcinoma. in Journal of proteome research 2007 (PubMed)

  4. Human Polyclonal Tufm Primary Antibody for ICC, IF - ABIN4363540 : Lei, Wen, Yu, Taxman, Zhang, Widman, Swanson, Wen, Damania, Moore, Giguère, Siderovski, Hiscott, Razani, Semenkovich, Chen, Ting: The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. in Immunity 2012 (PubMed)

  5. Cow (Bovine) Polyclonal Tufm Primary Antibody for WB - ABIN2787734 : Valente, Tiranti, Marsano, Malfatti, Fernandez-Vizarra, Donnini, Mereghetti, De Gioia, Burlina, Castellan, Comi, Savasta, Ferrero, Zeviani: Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu. in American journal of human genetics 2006 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Tu Translation Elongation Factor, Mitochondrial Interaction Partners

Human Tu Translation Elongation Factor, Mitochondrial (Tufm) interaction partners

  1. we identify a novel signaling hub centering on the NLRX1 (show NLRX1 Antibodies) TUFM protein complex, promoting autophagic flux. Defects in the expression of either NLRX1 (show NLRX1 Antibodies) or TUFM result in compromised autophagy when treated with EGFR (show EGFR Antibodies) inhibitors.These findings expand our understanding of the components involved in head and neck squamous cell carcinoma autophagy machinery that responds to EGFR (show EGFR Antibodies) inhibitors.

  2. TUFM is a novel regulator of epithelial-mesenchymal transition (EMT (show ITK Antibodies)); there may be a molecular link between mitochondrial dysfunction and EMT (show ITK Antibodies) induction

  3. NLRX1 (show NLRX1 Antibodies) and TUFM work in concert to reduce cytokine response and augment autophagy.

  4. Increased expression of TUFM is a promising new prognostic indicator for colorectal carcinoma.

  5. By recruiting Atg5 (show ATG5 Antibodies)-Atg12 (show ATG12 Antibodies) and NLRX1 (show NLRX1 Antibodies), TUFM serves as a nodal checkpoint of the RIG-I (show DDX58 Antibodies)-MAVS (show MAVS Antibodies) axis. It acts similarly to NLRX1 (show NLRX1 Antibodies) by inhibiting RigI (show DDX58 Antibodies)-like-receptor-induced IFN-I but promoting autophagy.

  6. Genetic investigation of patients with defective mitochondrial translation led to the discovery of novel mutations in the mitochondrial elongation factor G1 (EFG1 (show GFM1 Antibodies)) in one affected baby and in the mitochondrial elongation factor Tu (show EEF1A1 Antibodies) (EFTu) in another one

  7. Myoblasts isolated from the MELAS patients show A3243G mutation in tRNALeu(UUR) produces a severe respiratory chain deficiency and this phenotype can be partially suppressed by overexpression of EFTu and EFG2 (show GFM2 Antibodies).

  8. Results suggest that the R336Q mutant mt-EFTu variant fails to bind to aminoacylated mitochondrial tRNAs, thus explaining the observed impairment of mitochondrial translation.

Cow (Bovine) Tu Translation Elongation Factor, Mitochondrial (Tufm) interaction partners

  1. Loss of activity is caused by a significant reduction in the ability of EF-Ts (show TSFM Antibodies)(mt) R325W to bind EF-Tu(mt), leading to a defect in nucleotide exchange.

  2. Recombinant mitochondrial EF-Tu prevents thermal aggregation of proteins and enhances protein refolding in vitro.

  3. The arginine residue at position 335 of bovine mitochondrial elongation factor Tu (EF-Tu (show EEF1A1 Antibodies)) plays an important role in the binding and EF-Tu-mediated delivery of mitochondrial aminoacyl-tRNAs to the A-site of the ribosome.

Mouse (Murine) Tu Translation Elongation Factor, Mitochondrial (Tufm) interaction partners

  1. By recruiting Atg5 (show ATG5 Antibodies)-Atg12 (show ATG12 Antibodies) and NLRX1 (show NLRX1 Antibodies), TUFM serves as a nodal checkpoint of the RIG-I (show DDX58 Antibodies)-MAVS (show MAVS Antibodies) axis. It acts similarly to NLRX1 (show NLRX1 Antibodies) by inhibiting RigI (show DDX58 Antibodies)-like-receptor-induced IFN-I but promoting autophagy.

Tu Translation Elongation Factor, Mitochondrial (Tufm) Antigen Profile

Protein Summary

This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17.

Gene names and symbols associated with Tufm

  • Tu translation elongation factor, mitochondrial (TUFM) antibody
  • Tu translation elongation factor, mitochondrial (tufm) antibody
  • Tu translation elongation factor, mitochondrial (Tufm) antibody
  • 2300002G02Rik antibody
  • C76308 antibody
  • C76389 antibody
  • COXPD4 antibody
  • D250 antibody
  • EF-TuMT antibody
  • EFTU antibody
  • fi06f04 antibody
  • P43 antibody
  • TUFM antibody
  • wu:fi06f04 antibody
  • zgc:110766 antibody

Protein level used designations for Tufm

Tu translation elongation factor, mitochondrial , elongation factor Tu, mitochondrial-like , elongation factor Tu, mitochondrial , EF-Tu

GENE ID SPECIES
454018 Pan troglodytes
705462 Macaca mulatta
100455214 Pongo abelii
541378 Danio rerio
7284 Homo sapiens
479796 Canis lupus familiaris
281556 Bos taurus
233870 Mus musculus
293481 Rattus norvegicus
430889 Gallus gallus
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