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Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Additionally we are shipping Tubulin Folding Cofactor B Antibodies (86) and many more products for this protein.
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Human TBCB Protein expressed in Escherichia coli (E. coli) - ABIN1098304
Kortazar, Fanarraga, Carranza, Bellido, Villegas, Avila, Zabala: Role of cofactors B (TBCB) and E (TBCE) in tubulin heterodimer dissociation. in Experimental cell research 2007
Show all 2 references for ABIN1098304
the role of the human TBCE (show TBCE Proteins) and TBCB chaperones in alpha-tubulin (show TUBA4A Proteins)-beta-tubulin (show TUBB Proteins) dissociation, was investigated.
results support a role for MAP1 (show MASP1 Proteins) proteins in promoting efficient retrograde trafficking of HIV-1 by stimulating the formation of stable microtubules and mediating the association of HIV-1 cores with microtubules.
Overexpression of TBCB leads to the decreased localization of p150 to the microtubule network that might result in a functional modulation of this protein complex.
TBCB localizes at spindle and midzone microtubules during mitosis.
These findings identified TCoB as the third cytoskeleton protein to be nitrated and suggest a previously undescribed mechanism, whereby growth factor signaling may coordinately integrate nitric oxide signaling in the regulation of microtubule dynamics.
TBCB functions as a microtubule density regulator in microglia during activation, and provide an insight into understanding of mechanisms controlling microtubule reorganization during microglial transition between phenotypes.
Study demonstrates that, unlike its counterpart TBCE (show TBCE Proteins), TBCB only moderately destabilizes microtubules; neither TBCB abundance nor microtubule organization or densities are altered in giant axonal neuropathy (show GAN Proteins) mutant fibroblasts.
We show that TBCB overexpression depolymerizes microtubules. We found that this function is based on the ability of TBCB to form a binary complex with TBCE (show TBCE Proteins) that greatly enhances the efficiency of this cofactor to dissociate tubulin (show TUBB Proteins) in vivo and in vitro.
Results indicate a developmental function for the tubulin (show TUBB Proteins)-binding cofactor B (dTBCB) gene that is essential for viability and microtubules (MTs (show NEU2 Proteins))-dependent cell polarity, but not cell division.
Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity).
tubulin folding cofactor B
, cytoskeleton associated protein 1
, tubulin-folding cofactor B
, cytoskeleton-associated protein 1
, cytoskeleton-associated protein CKAPI
, tubulin-specific chaperone B
, tubulin-folding cofactor B-like
, liver cancer related protein