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May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. Additionally we are shipping Tppp Kits (38) and Tppp Proteins (7) and many more products for this protein.
Showing 10 out of 69 products:
Chicken Polyclonal Tppp Primary Antibody for WB - ABIN2780164
Tirián, Hlavanda, Oláh, Horváth, Orosz, Szabó, Kovács, Szabad, Ovádi: TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation. in Proceedings of the National Academy of Sciences of the United States of America 2003
Human Polyclonal Tppp Primary Antibody for EIA, IHC (p) - ABIN499122
Ovádi, Orosz: An unstructured protein with destructive potential: TPPP/p25 in neurodegeneration. in BioEssays : news and reviews in molecular, cellular and developmental biology 2009
the central folded domain of TPPP/p25 following binding to microtubules can drive s homotypic protein-protein interactions leading to bundled microtubules.
Results reveal a link between p25 (show LCN2 Antibodies) and BACE1 (show BACE Antibodies) in Alzheimer disease (AD) brains and suggest that upregulated Cdk5 (show CDK5 Antibodies) activation by p25 (show LCN2 Antibodies) accelerates AD pathogenesis by enhancing BACE1 (show BACE Antibodies) activity via phosphorylation.
Epigenetic changes in TPPP, in combination with experiences of maltreatment, may confer risk for depression in children.
suggest that the zinc as a specific divalent cation could be involved in the fine-tuning of the physiological TPPP/p25 level counteracting both the enrichment and the lack of this protein leading to distinct central nervous system diseases
results suggest that ROCK regulates beta-catenin (show CTNNB1 Antibodies) stability in cells via preventing TPPP1-mediated inhibition of HDAC6 (show HDAC6 Antibodies) activity, to reduce its acetylation and degradation via phosphorylation by CK1 (show CSNK1A1L Antibodies) and GSK3beta (show GSK3b Antibodies)
GSK3 (show GSK3b Antibodies) promotes the mitochondrial translocation of p53 (show TP53 Antibodies), enabling its interaction with Bcl2 (show BCL2 Antibodies) to allow Bax (show BAX Antibodies) oligomerization and the subsequent release of cytochrome C (show CYCS Antibodies).
dual Rock and Cdk (show CDK4 Antibodies) phosphorylation of Tppp1 inhibits its regulation of the cell cycle to increase cell proliferation
The RhoA (show RHOA Antibodies)-ROCK-LIMK2 (show LIMK2 Antibodies)-TPPP pathway controls metaphase spindle-orientation; TPPP colocalizes with LIMK2 (show LIMK2 Antibodies) at the mitotic spindle.
Although serine-129 phosphorylation of alpha-synuclein (show SNCA Antibodies) facilitates TPPP-mediated alpha-SYN oligomerization, this modification does not seem to play an inevitable role in the early step of alpha-SYN oligomer formation in a cellular model of multiple system atrophy.
The authors conclude that the modest structural changes that p25alpha undergoes can promote weak intermolecular contacts and that polyanions such as heparin play a central role in stabilizing these aggregates.
These results support an essential role for TPPP/p25 in oligodendrocyte differentiation likely via rearrangement of the microtubule system during the process elongation prior to the onset of myelination.
LIMK1 phosphorylation of p25 blocks p25 activity, thus promoting microtubule disassembly.
A pathway was discovered by which p25 (show CDK5R1 Antibodies) and cdk5 (show CDK5 Antibodies) increases the amyloidogenic processing of amyloid precursor protein (show APP Antibodies).
May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.
brain-specific protein p25 alpha
, 25 kDa brain-specific protein
, brain specific protein p25 alpha
, glycogen synthase kinase 3 (GSK3) inhibitor p24
, tubulin polymerization-promoting protein
, tubulin polymerization promoting protein p25 alpha