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Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Additionally we are shipping Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 Proteins (11) and many more products for this protein.
Showing 10 out of 53 products:
Human Polyclonal TNFAIP8L2 Primary Antibody for EIA, WB - ABIN955273
Zhang, Hao, Lou, Xi, Wang, Wang, Qu, Guo, Chen, Zhang, Liu: Tissue-specific expression of TIPE2 provides insights into its function. in Molecular immunology 2010
Human Polyclonal TNFAIP8L2 Primary Antibody for ELISA, WB - ABIN1450851
Sun, Gong, Carmody, Hilliard, Li, Sun, Kong, Xu, Hilliard, Hu, Shen, Yang, Chen: TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis. in Cell 2008
The TIPE2-elicited antimetastatic effect in gastric cancer was closely associated with the inhibition of AKT signaling and enhancement of GSK3b activity followed by the degradation and decreased translocation to nucleus of b-catenin
TIPE2 promoted lung cancer cell apoptosis through affecting apoptosis-related molecules caspase-3 (show CASP3 Antibodies), caspase-9 (show CASP9 Antibodies), Bcl-2 (show BCL2 Antibodies) and Bax (show BAX Antibodies), possibly via regulating P38 (show CRK Antibodies) and Akt (show AKT1 Antibodies) pathways.
Tumor necrosis factor-alpha-induced protein-8 like-2 (TIPE2) upregulates p27 (show PAK2 Antibodies) to decrease gastic cancer cell proliferation
TIPE2 mRNA showed sensitivity of 74.63%, specificity of 90.24%, positive predictive value of 92.5%, and negative predictive value of 67.3% for predicting 3-month mortality in Acute-on-Chronic Hepatitis B Liver Failure.
These results strongly suggest that TIPE2 plays an important role in shifting L-arginase (show ARG1 Antibodies) metabolism from production of NO to urea, during host inflammatory response.
Both TNF-alpha (show TNF Antibodies) and TIPE2 might be potential targets for the treatment of hepatocellular carcinoma metastasis.
TIPE2 might serve as a tumor suppressor in non-small cell lung cancer progression.
TIPE2 can inhibit caspase-8 (show CASP8 Antibodies) activity in colon cancer cells. TIPE2 can regulate TLR4 (show TLR4 Antibodies) inflammatory effect and inhibit further amplification of cascade reaction via caspase-8 (show CASP8 Antibodies).
TIPE2 plays an important role in regulating hepatitis B virus-specific CD8 (show CD8A Antibodies)(+) T cell functions in patients with hepatitis B.
Human TIPE2 is an endogenous inhibitor of Rac1 in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) by which it attenuates invasion and metastasis of HCC (show FAM126A Antibodies).
TIPE2 acts as a negative regulator linking NOD2 (show NOD2 Antibodies) and inflammatory responses.
TIPE2 plays a suppressive role in injury-induced restenosis and may serve as a new therapeutic target for treating the disease.
Tipe2 provides a molecular bridge between miR (show MLXIP Antibodies)-21 and cell apoptosis; miR (show MLXIP Antibodies)-21 suppresses apoptosis in activated T cells at least in part through directly targeting tumor suppressor gene Tipe2.
TIPE2 deficiency in hematopoietic cells ameliorates experimental colitis; TIPE2 is a negative regulator of antibacterial immunity, indicating that TIPE2 promotes colitis by inhibiting mucosal immunity to commensal bacteria.
TIPE2 plays a crucial atheroprotective role likely by regulating macrophage responses to oxidized low-density lipoprotein.
study reports that TIPE2, the tumor necrosis factor-alpha-induced protein 8-like 2, plays an atheroprotective role by regulating phenotypic switching of vascular smooth muscle cells in response to oxidized low-density lipoprotein stimuli
TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection
TIPE2 plays an essential role in a signal transduction pathway that links the inflammatory immune response to specific conditions after cerebral ischemia.
TIPE2 regulates polyinosinic-polycytidylic acid [poly I:C]-induced innate immune responses by targeting Rac (show AKT1 Antibodies) GTPase (show RACGAP1 Antibodies) pathways in a phosphatidylinositol 3-kinase (PI3K)-dependent manner.
The results suggested that TIPE2 appeared to be a critical immunoregulatory molecule involved in immunosuppressive function of CD4 (show CD4 Antibodies)(+)CD25 (show IL2RA Antibodies)(+) Tregs.
Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).
TNF alpha-induced protein 8-like protein 2
, TNFAIP8-like protein 2
, inflammation factor 20
, inflammation factor protein 20
, tumor necrosis factor alpha-induced protein 8-like protein 2
, tumor necrosis factor, alpha-induced protein 8-like protein 2
, Tumor necrosis factor, alpha-induced protein 8-like protein 2
, tumor necrosis factor, alpha-induced protein 8-like protein 2 a