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Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 Proteins (TNFAIP8L2)

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Additionally we are shipping Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 Antibodies (53) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNFAIP8L2 79626 Q6P589
TNFAIP8L2 69769 Q9D8Y7
Rat TNFAIP8L2 TNFAIP8L2 310663 Q6AYJ8
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Top Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Primates His tag   1 mg Log in to see 56 to 66 Days
$2,436.50
Details
Yeast Rhinoceros His tag   1 mg Log in to see 56 to 66 Days
$2,436.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,436.50
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,436.50
Details
Yeast Callithrix jacchus His tag   1 mg Log in to see 56 to 66 Days
$2,436.50
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,442.00
Details
Yeast REACT_Atlantic Salmon His tag   1 mg Log in to see 56 to 66 Days
$2,442.00
Details

TNFAIP8L2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 (TNFAIP8L2) Interaction Partners

Human Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 (TNFAIP8L2) interaction partners

  1. The TIPE2-elicited antimetastatic effect in gastric cancer was closely associated with the inhibition of AKT signaling and enhancement of GSK3b activity followed by the degradation and decreased translocation to nucleus of b-catenin

  2. TIPE2 promoted lung cancer cell apoptosis through affecting apoptosis-related molecules caspase-3 (show CASP3 Proteins), caspase-9 (show CASP9 Proteins), Bcl-2 (show BCL2 Proteins) and Bax (show BAX Proteins), possibly via regulating P38 (show CRK Proteins) and Akt (show AKT1 Proteins) pathways.

  3. Tumor necrosis factor-alpha-induced protein-8 like-2 (TIPE2) upregulates p27 (show PAK2 Proteins) to decrease gastic cancer cell proliferation

  4. TIPE2 mRNA showed sensitivity of 74.63%, specificity of 90.24%, positive predictive value of 92.5%, and negative predictive value of 67.3% for predicting 3-month mortality in Acute-on-Chronic Hepatitis B Liver Failure.

  5. These results strongly suggest that TIPE2 plays an important role in shifting L-arginase (show ARG1 Proteins) metabolism from production of NO to urea, during host inflammatory response.

  6. Both TNF-alpha (show TNF Proteins) and TIPE2 might be potential targets for the treatment of hepatocellular carcinoma metastasis.

  7. TIPE2 might serve as a tumor suppressor in non-small cell lung cancer progression.

  8. TIPE2 can inhibit caspase-8 (show CASP8 Proteins) activity in colon cancer cells. TIPE2 can regulate TLR4 (show TLR4 Proteins) inflammatory effect and inhibit further amplification of cascade reaction via caspase-8 (show CASP8 Proteins).

  9. TIPE2 plays an important role in regulating hepatitis B virus-specific CD8 (show CD8A Proteins)(+) T cell functions in patients with hepatitis B.

  10. Human TIPE2 is an endogenous inhibitor of Rac1 in hepatocellular carcinoma (HCC (show FAM126A Proteins)) by which it attenuates invasion and metastasis of HCC (show FAM126A Proteins).

Mouse (Murine) Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 (TNFAIP8L2) interaction partners

  1. TIPE2 alleviates experimental SLE through induction of macrophage polarization to a M2 phenotype, which may be used as a promising therapeutic strategy for treating SLE.

  2. TIPE2 acts as a negative regulator linking NOD2 and inflammatory responses.

  3. TIPE2 plays a suppressive role in injury-induced restenosis and may serve as a new therapeutic target for treating the disease.

  4. Tipe2 provides a molecular bridge between miR (show MLXIP Proteins)-21 and cell apoptosis; miR (show MLXIP Proteins)-21 suppresses apoptosis in activated T cells at least in part through directly targeting tumor suppressor gene Tipe2.

  5. TIPE2 deficiency in hematopoietic cells ameliorates experimental colitis; TIPE2 is a negative regulator of antibacterial immunity, indicating that TIPE2 promotes colitis by inhibiting mucosal immunity to commensal bacteria.

  6. TIPE2 plays a crucial atheroprotective role likely by regulating macrophage responses to oxidized low-density lipoprotein.

  7. study reports that TIPE2, the tumor necrosis factor-alpha-induced protein 8-like 2, plays an atheroprotective role by regulating phenotypic switching of vascular smooth muscle cells in response to oxidized low-density lipoprotein stimuli

  8. TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection

  9. TIPE2 plays an essential role in a signal transduction pathway that links the inflammatory immune response to specific conditions after cerebral ischemia.

  10. TIPE2 regulates polyinosinic-polycytidylic acid [poly I:C]-induced innate immune responses by targeting Rac (show AKT1 Proteins) GTPase (show RACGAP1 Proteins) pathways in a phosphatidylinositol 3-kinase (PI3K)-dependent manner.

Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 (TNFAIP8L2) Protein Profile

Protein Summary

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).

Gene names and symbols associated with TNFAIP8L2

  • tumor necrosis factor, alpha-induced protein 8-like 2 (TNFAIP8L2)
  • tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2)
  • tumor necrosis factor, alpha-induced protein 8-like 2 (tnfaip8l2-a)
  • Tumor necrosis factor, alpha-induced protein 8-like protein 2 (tp8l2)
  • 1810019A08Rik protein
  • AW610835 protein
  • RGD1310519 protein
  • TIPE2 protein
  • tnfaip8l2 protein

Protein level used designations for TNFAIP8L2

TNF alpha-induced protein 8-like protein 2 , TNFAIP8-like protein 2 , inflammation factor 20 , inflammation factor protein 20 , tumor necrosis factor alpha-induced protein 8-like protein 2 , tumor necrosis factor, alpha-induced protein 8-like protein 2 , TIPE2 , Tumor necrosis factor, alpha-induced protein 8-like protein 2 , tumor necrosis factor, alpha-induced protein 8-like protein 2 a

GENE ID SPECIES
79626 Homo sapiens
69769 Mus musculus
310663 Rattus norvegicus
510652 Bos taurus
100328663 Oryctolagus cuniculus
399018 Xenopus laevis
100195718 Salmo salar
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