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Tumor Necrosis Factor (Ligand) Superfamily, Member 18 Proteins (TNFSF18)

The protein encoded by TNFSF18 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. Additionally we are shipping Tumor Necrosis Factor (Ligand) Superfamily, Member 18 Antibodies (144) and Tumor Necrosis Factor (Ligand) Superfamily, Member 18 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNFSF18 8995 Q9UNG2
TNFSF18 240873 Q7TS55
Rat TNFSF18 TNFSF18 364031  
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Top Tumor Necrosis Factor (Ligand) Superfamily, Member 18 Proteins at antibodies-online.com

Showing 10 out of 31 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Human DYKDDDDK Tag Flag-tagged GITRL bound to GITR transfected cells. HEK-293 cells were transiently transfected with a construct encoding human GITR full length. At 48hr after transfection, the transfectants were incubated with 5μg/ml of human FLAG-tagged GITRL  protein and followed by flow cytometric analysis with anti-FLAG M2-FITC. 50 μg Log in to see 5 to 8 Days
$446.25
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_HEK-293 Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$135.88
Details
HOST_Human Mouse DYKDDDDK Tag   50 μg Log in to see 5 to 8 Days
$425.25
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_HEK-293 Cells Human Fc Tag 50 μg Log in to see 2 to 3 Days
$385.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$882.00
Details

TNFSF18 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, , , , ,
Mouse (Murine) , ,
, ,

Top referenced Tumor Necrosis Factor (Ligand) Superfamily, Member 18 Proteins

  1. Human TNFSF18 Protein expressed in HEK-293 - ABIN2666573 : Azuma: Role of the glucocorticoid-induced TNFR-related protein (GITR)-GITR ligand pathway in innate and adaptive immunity. in Critical reviews in immunology 2010 (PubMed)
    Show all 8 references for ABIN2666573

  2. Human TNFSF18 Protein expressed in Escherichia coli (E. coli) - ABIN667587 : Gurney, Marsters, Huang, Pitti, Mark, Baldwin, Gray, Dowd, Brush, Heldens, Schow, Goddard, Wood, Baker, Godowski, Ashkenazi: Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. in Current biology : CB 1999 (PubMed)
    Show all 2 references for ABIN667587

More Proteins for Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18) Interaction Partners

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18) interaction partners

  1. An increase in GITRL may impair the balance of Th17/Treg, and contribute to the pathopoiesis of Hashimoto's thyroiditis.

  2. Our findings indicate the possible involvement of GITR (show TNFRSF18 Proteins)-GITRL pathway in the pathogenesis of pSS (show CDSN Proteins).

  3. Serum GITRL levels were higher in SLE patients.

  4. Glucocorticoid-induced TNF-related ligand (GITRL) confers pseudoexpression to tumor cells by platelets, which results in GITRL expression by megakaryocytes and their platelet progeny.

  5. observation suggests a link between cytokine-regulated keratinocyte GITRL expression and its role in inflammatory responses in AD

  6. GITRL upregulation induced by IFN-beta (show IFNB1 Proteins) on dendritic cells downregulates CTLA-4 (show CTLA4 Proteins) on regulatory T (Treg) cells, facilitating proliferation of anergic Treg cells in multiple sclerosis treatment of multiple sclerosis patients.

  7. Although GITR (show TNFRSF18 Proteins) transgene costimulation can therapeutically enhance T helper (Th) type 2 cell responses, GITR-GITR (show TNFRSF18 Proteins) ligand interactions are not required for development of Th2-mediated resistance or pathology.

  8. GITRL expression on Kupffer cells may mediate acute rejection in liver transplantation

  9. The incorporation of an isoleucine zipper motif could markedly improve the costimulation of hsGITRL.

  10. Upregulation by proinflammatory cytokines suggests GITRL may play important role in ocular immunity. High level of constitutive GITRL expression on photoreceptor inner segments suggests photoreceptors participate in regulation of ocular inflammation.

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18) interaction partners

  1. the upregulation of IFN-beta (show IFNB1 Proteins) in DCs induces the up-regulation of coinhibitory molecules B7H1 (show CD274 Proteins) and GITRL, which cause an impaired activation of naive Ag-specific T cells

  2. GITRL expressed on macrophages drives cytokine release and T cell activation, resulting in neuropathic pain via GITR (show TNFRSF18 Proteins)-dependent actions. The GITRL-GITR (show TNFRSF18 Proteins) pathway might represent a novel target for the treatment of neuropathic pain.

  3. Down-regulation of GITRL enhances CD8 (show CD8A Proteins) T cell responses to chronic lymphocytic choriomeningitis virus.

  4. Sjogren's syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand (show TNFSF9 Proteins).

  5. GITRL triggering in endothelial cells increases leukocyte adhesion and transmigration.

  6. The B7H1 (show CD274 Proteins) and GITRL molecules may play an important role in TGF-beta (show TGFB1 Proteins)-induced Treg expansion of lung cancer microenvironment.

  7. results demonstrate that enhanced GITR (show TNFRSF18 Proteins)/GITRL interactions have a pleiotropic role on the regulation of T-cell responses

  8. B cell expression of GITRL induced Treg proliferation, maintaining their numbers above a threshold required for the prevention of autoimmunity.

  9. Findings suggest GITRL could enhance the immune stimulation of DC and might facilitate the potential development of DCs-based anti-tumor therapies.

  10. GITRL-dependent expansion of Treg within the cornea is one mechanism underlying immune privilege in corneal allografts.

Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18) Protein Profile

Protein Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.

Gene names and symbols associated with TNFSF18

  • tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18)
  • tumor necrosis factor (ligand) superfamily, member 18 (Tnfsf18)
  • AITRL protein
  • Gitrl protein
  • hGITRL protein
  • TL6 protein

Protein level used designations for TNFSF18

AITR ligand , GITR ligand , activation-inducible TNF-related ligand , glucocorticoid-induced TNF-related ligand , glucocorticoid-induced TNFR-related protein ligand , tumor necrosis factor ligand superfamily member 18 , glucocorticoid-induced-tumor necrosis factor receptor ligand

GENE ID SPECIES
8995 Homo sapiens
240873 Mus musculus
364031 Rattus norvegicus
611257 Canis lupus familiaris
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