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Tumor Necrosis Factor (Ligand) Superfamily, Member 4 Proteins (TNFSF4)

The protein encoded by TNFSF4 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. Additionally we are shipping TNFSF4 Antibodies (245) and TNFSF4 Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNFSF4 7292 P23510
TNFSF4 22164 P43488
Rat TNFSF4 TNFSF4 89814 Q9Z2P3
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Top TNFSF4 Proteins at antibodies-online.com

Showing 10 out of 22 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Human Un-conjugated 100 μg Log in to see 10 to 12 Days
$1,081.63
Details
HOST_Human Cells Cynomolgus Fc Tag 50 μg Log in to see 16 Days
$382.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_HEK293 Human DYKDDDDK Tag   10 μg Log in to see 5 to 8 Days
$362.25
Details
HOST_HEK-293T Human His-DYKDDDDK-Strep II Tag 25 μg Log in to see 9 Days
$914.29
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,308.17
Details

TNFSF4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , , , , ,
, , , , ,
Mouse (Murine) , , , ,
, , ,

Top referenced TNFSF4 Proteins

  1. Human TNFSF4 Protein expressed in HEK-293 - ABIN2666855 : Aspord, Leccia, Charles, Plumas: Plasmacytoid dendritic cells support melanoma progression by promoting Th2 and regulatory immunity through OX40L and ICOSL. in Cancer immunology research 2014 (PubMed)
    Show all 5 references for ABIN2666855

  2. Human TNFSF4 Protein expressed in HEK293 - ABIN1344408 : Mestas, Crampton, Hori, Hughes: Endothelial cell co-stimulation through OX40 augments and prolongs T cell cytokine synthesis by stabilization of cytokine mRNA. in International immunology 2005 (PubMed)

  3. Cynomolgus TNFSF4 Protein expressed in Human Cells - ABIN2009818 : Weiguang, Dalin, Lidan, Yonggang, Shuang, Yanhong, Fengyan, Zhenkun, Da, Dianjun: Association of OX40L polymorphisms with sporadic breast cancer in northeast Chinese Han population. in PLoS ONE 2012 (PubMed)

More Proteins for Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4) Interaction Partners

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4) interaction partners

  1. Given the discovery cohort, functional data, and importance of TNFSF4 in infection clearance, TNFSF4C may associate with outcomes and warrants future studies.

  2. Review/Meta-analysis: TNFSF4 (rs3850641) polymorphisms is not associated with coronary heart disease risk.

  3. Study showed that the A allele of the rs7518045 and haplotype rs3861950C-rs17346501C-rs7518045A-rs1234313G in the TNFSF4 gene were associated with decreased risk for myocardial infarction in a Chinese Han population.

  4. Data indicate that soluble OX40 (show TNFRSF4 Proteins) and sOX40L plasma levels are increased in early rheumatoid arthritis patients.

  5. Report role of TNFSF4 genetic variants in confering risk of systemic lupus erythematosus in Chinese population.

  6. There were no significant associations between rs1234313, rs1234314 and rs17568 and atherosclerotic cerebral infarction risk in a Han Chinese population.

  7. Blocking of the interaction between OX40 and OX40L in vitro inhibited production of Thl and Th2 type cytokines in acute renal allograft rejection.

  8. TNFSF4 gene polymorphism rs3861950, but not rs3850641, is associated with the risk of atherosclerosis CI in a Chinese population.

  9. The results of a meta-analysis suggest that the TNFSF4 rs2205960 polymorphism may confer susceptibility to systemic lupus erythematosus (SLE) in different populations and that the TNFSF4 rs1234315 polymorphism is associated with susceptibility to SLE in Asians.

  10. Our data firstly replicated the association of TNFSF4 with renal disorder in SLE patients in the Chinese population, which supported that TNFSF4 may act as a marker of lupus nephritis

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4) interaction partners

  1. Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin (show TSLP Proteins), and IL-33 (show IL33 Proteins)

  2. Anti-OX40L mAb could prolong secondary heart allograft survival based on CD40 (show CD40 Proteins)/CD40L (show CD40LG Proteins) and LFA-1 (show ITGAL Proteins)/ICAM-1 (show ICAM1 Proteins) blockade.

  3. intestinal Th2 priming is initiated by an autocrine/paracrine acting CD4 (show CD4 Proteins)(+) Th cell-intrinsic IL-4 (show IL4 Proteins) program that is controlled by DC OX40L, and not by NKT (show CTSL1 Proteins), gammadelta T, or ILC (show CCL27 Proteins) cells.

  4. a critical role of OX40L presented by the activated basophils to initiate Th2 responses in an allergic asthma model, implicating OX40 (show TNFRSF4 Proteins)-OX40L signaling as a potential therapeutic target in the treatment of allergic airway inflammation.

  5. The majority of transferred CD40L (show CD40LG Proteins)(-/-) T cells in Rag-1 (show RAG1 Proteins)(-/-) B6 mice were differentiated to CD44 (show CD44 Proteins)(high).

  6. OX40 (show TNFRSF4 Proteins)-OX40L interaction regulates the expression of NFATc1 (show NFATC1 Proteins), which may play a critical role in atherosclerotic plaque formation, and may therefore have implications with pathophysiology of atherosclerosis.

  7. The need for additional immune suppression in the intestine reflects commensal microbe-driven T-cell activation through the accessory costimulation molecules ICOSL (show ICOSLG Proteins) and OX40L in B7 deprived mice.

  8. we identify a previously unknown role for OX40L in steady-state bone homeostasis

  9. Data indicate that OX40L contributes to both the development of Th2 cells and secondary Th2 responses induced by KLH-pulsed CD8 (show CD8A Proteins)- cDCs in vivo.

  10. interruption of the OX40-OX40L signaling pathway, with decreases in dietary cholesterol, induces regression of atherosclerosis by induction of IL-5-producing T cells and oxidized low-density lipoprotein-specific IgM and reductions in Th2 and mast cells.

TNFSF4 Protein Profile

Protein Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.

Gene names and symbols associated with TNFSF4

  • tumor necrosis factor (ligand) superfamily, member 4 (TNFSF4)
  • tumor necrosis factor (ligand) superfamily, member 4 (Tnfsf4)
  • Ath-1 protein
  • Ath1 protein
  • CD134L protein
  • CD252 protein
  • gp34 protein
  • OX-40L protein
  • OX4OL protein
  • Ox40l protein
  • TNFRSF4 protein
  • TNFSF4 protein
  • TXGP1 protein
  • Txgp1l protein

Protein level used designations for TNFSF4

tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa) , tumor necrosis factor (ligand) superfamily, member 4 , tumor necrosis factor ligand superfamily member 4 , CD134(OX40)-ligand , OX40L protein , CD134 ligand , OX40 antigen ligand , OX40L , TAX transcriptionally-activated glycoprotein 1 , glycoprotein Gp34 , tax-transcriptionally activated glycoprotein 1 (34kD) , OX40 ligand , atherosclerosis 1 , tax-transcriptionally activated glycoprotein 1 ligand

GENE ID SPECIES
469586 Pan troglodytes
490339 Canis lupus familiaris
539800 Bos taurus
706255 Macaca mulatta
790947 Felis catus
574053 Sus scrofa
7292 Homo sapiens
22164 Mus musculus
89814 Rattus norvegicus
100008595 Oryctolagus cuniculus
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