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Tumor Necrosis Factor (Ligand) Superfamily, Member 9 Proteins (TNFSF9)

The protein encoded by TNFSF9 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. Additionally we are shipping TNFSF9 Antibodies (152) and TNFSF9 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNFSF9 353218  
TNFSF9 21950 P41274
TNFSF9 8744 P41273
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Top TNFSF9 Proteins at antibodies-online.com

Showing 10 out of 36 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Rat Fc Tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Rat His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Human Human DYKDDDDK Tag   50 μg Log in to see 5 to 8 Days
$446.25
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_HEK-293 Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$135.88
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details

TNFSF9 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)
,
Mouse (Murine) , , ,
, ,
Human , , , , , ,
, , , , ,

Top referenced TNFSF9 Proteins

  1. Human TNFSF9 Protein expressed in HEK-293 - ABIN2666577 : Locatelli: Tolerance: pregnancy matters. in Blood 2009 (PubMed)
    Show all 7 references for ABIN2666577

  2. Human TNFSF9 Protein expressed in Escherichia coli (E. coli) - ABIN667100 : Lee, Park, So, Kwon, Cheroutre, Mittler, Croft: Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells. in Nature immunology 2008 (PubMed)
    Show all 2 references for ABIN667100

  3. Human TNFSF9 Protein expressed in Human - ABIN1344405 : Rabu, Quéméner, Jacques, Echasserieau, Vusio, Lang: Production of recombinant human trimeric CD137L (4-1BBL). Cross-linking is essential to its T cell co-stimulation activity. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for ABIN1344405

  4. Mouse (Murine) TNFSF9 Protein expressed in Human Cells - ABIN2007262 : Goodwin, Din, Davis-Smith, Anderson, Gimpel, Sato, Maliszewski, Brannan, Copeland, Jenkins: Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. in European journal of immunology 1993 (PubMed)
    Show all 2 references for ABIN2007262

  5. Rat (Rattus) TNFSF9 Protein expressed in Human Cells - ABIN2009238 : Alderson, Smith, Tough, Davis-Smith, Armitage, Falk, Roux, Baker, Sutherland, Din: Molecular and biological characterization of human 4-1BB and its ligand. in European journal of immunology 1994 (PubMed)

More Proteins for Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) Interaction Partners

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) interaction partners

  1. 4-1BBL can restrain effector T cell development, creating a more favorable regulatory T cell to effector cell balance under tolerogenic conditions, and this may be particularly active in mucosal barrier tissues

  2. These results demonstrate that 4-1BBL-engineered DCs can improve CIKs (show TRAF3IP2 Proteins) cytotoxicity against prostate cancer cells.

  3. these observations suggest that inhibition of the TLR/4 (show TLR4 Proteins)-1BBL complex formation may be highly efficient in protecting against continued inflammation

  4. 4-1BB (show TNFRSF9 Proteins) mediates the inflammatory responses in obese skeletal muscle by interacting with its ligand 4-1BBL on macrophages.

  5. CD137 (show TNFRSF9 Proteins)-CD137L interactions mediated via regulation of CyPA (show PPIA Proteins) contribute to the progression of atherosclerosis.

  6. Data indicate that CD137L deficient mice displayed a variety of immunological dysfunctions.

  7. monocytes interact with iNKT cells to increase expression of 4-1BBL and 4-1BB (show TNFRSF9 Proteins), and in conjunction with this pathway, maintain their numbers at baseline.

  8. CD137 (show TNFRSF9 Proteins)-expressing CD4 (show CD4 Proteins)+ T cells in the bone marrow engage CD137L on hematopoietic progenitor cells, and this CD137L signaling biases hematopoiesis towards myelopoiesis during aging.

  9. TIRAP (show TIRAP Proteins) and IRAK2 (show IRAK2 Proteins) are critical for the sustained inflammatory response that is mediated by late-phase signaling by the TLR-4 (show TLR4 Proteins)-1BBL complex.

  10. Results suggest that CD137L reverse signaling exerts a pro-apoptotic effect by suppressing integrin-mediated survival signals in neural stem cells.

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) interaction partners

  1. CD137L is overexpressed in non-small cell lung cancer specimens and positive expression of CD137L was associated with better overall survival.

  2. In vitro immunotherapy is described for anti-prostate cancer effects of cytotoxic T lymphocytes induction by recombinant adenovirus mediated PSMA/4 (show PSMA4 Proteins)-1BBL dendritic cells.

  3. vaccination with recombinant attenuated Salmonella harboring the CEACAM6 and 4-1BBL gene efficiently increased the number of CD3 (show CD3 Proteins)+CD8 (show CD8A Proteins)+ TIL (show TLR1 Proteins) and NK cells, decreased the number of FOXP3 (show FOXP3 Proteins) cells and inhibited the development of DMH (show DST Proteins)-induced colorectal cancer

  4. Elevated plasma levels and monocyte-associated expression of CD137 (show TNFRSF9 Proteins) ligand in patients with acute atherothrombotic stroke

  5. Hence, the targeted combination of IL-15 (show IL15 Proteins) and 4-BBL (show TP53 Proteins) in the form of a trifunctional antibody-fusion protein is a promising new approach for cancer immunotherapy.

  6. monocytes interact with iNKT cells to increase expression of 4-1BBL and 4-1BB (show TNFRSF9 Proteins), and in conjunction with this pathway, maintain their numbers at baseline.

  7. TIRAP (show TIRAP Proteins) and IRAK2 (show IRAK2 Proteins) are critical for the sustained inflammatory response that is mediated by late-phase signaling by the TLR-4 (show TLR4 Proteins)-1BBL complex.

  8. this is the first study to indicate that this member of the TNF (show TNF Proteins) superfamily, CD137 (show TNFRSF9 Proteins), is modulated by SAHA treatment in breast

  9. Data show that TNFR1 (show TNFRSF1A Proteins) associates with CD137L and is required for CD137L reverse signaling.

  10. CD137L is a novel diagnostic marker of subtypes of non-Hodgkin B-cell lymphomas.

TNFSF9 Protein Profile

Protein Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.

Gene names and symbols associated with TNFSF9

  • tumor necrosis factor (ligand) superfamily, member 9 (Tnfsf9)
  • tumor necrosis factor (ligand) superfamily, member 9 (TNFSF9)
  • 4-1BB-L protein
  • 4-1BBL protein
  • AI848817 protein
  • CD137L protein
  • Ly63l protein
  • TNFSF9 protein

Protein level used designations for TNFSF9

costimulatory molecule , tumor necrosis factor (ligand) superfamily, member 9 , 4-1BB ligand , tumor necrosis factor ligand superfamily member 9 , 4-1BBL , homolog of mouse 4-1BB-L , receptor 4-1BB ligand

GENE ID SPECIES
353218 Rattus norvegicus
476729 Canis lupus familiaris
521748 Bos taurus
21950 Mus musculus
8744 Homo sapiens
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