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Tumor Necrosis Factor Receptor Superfamily, Member 11b (Osteoprotegerin) Proteins (TNFRSF11B)

Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Additionally we are shipping Tumor Necrosis Factor Receptor Superfamily, Member 11b (Osteoprotegerin) Antibodies (49) and Tumor Necrosis Factor Receptor Superfamily, Member 11b (Osteoprotegerin) Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNFRSF11B 690  
Rat TNFRSF11B TNFRSF11B 25341 O08727
TNFRSF11B 18383 O08712
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Top Tumor Necrosis Factor Receptor Superfamily, Member 11b (Osteoprotegerin) Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Mouse Un-conjugated 25 μg Log in to see 10 to 12 Days
$135.88
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Cynomolgus Fc Tag 100 μg Log in to see 16 Days
$272.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_HEK-293T Human His-DYKDDDDK-Strep II Tag 25 μg Log in to see 9 Days
$914.29
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 3 to 4 Days
$190.93
Details
Yeast Human Un-conjugated   100 μg Log in to see 9 to 11 Days
$272.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 11 Days
$272.80
Details

TNFRSF11B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, ,
Mouse (Murine) , ,
,

Top referenced Tumor Necrosis Factor Receptor Superfamily, Member 11b (Osteoprotegerin) Proteins

  1. Mouse (Murine) TNFRSF11B Protein expressed in HEK-293 - ABIN2666866 : Boyce, Xing: Biology of RANK, RANKL, and osteoprotegerin. in Arthritis research & therapy 2007 (PubMed)
    Show all 7 references for ABIN2666866

  2. Cynomolgus TNFRSF11B Protein expressed in Human Cells - ABIN2009907 : Simonet, Lacey, Dunstan, Kelley, Chang, Lüthy, Nguyen, Wooden, Bennett, Boone, Shimamoto, DeRose, Elliott, Colombero, Tan, Trail, Sullivan, Davy, Bucay, Renshaw-Gegg, Hughes, Hill, Pattison, Campbell et al.: Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. ... in Cell 1997 (PubMed)
    Show all 4 references for ABIN2009907

  3. Human TNFRSF11B Protein expressed in Human Cells - ABIN2002484 : Yasuda, Shima, Nakagawa, Mochizuki, Yano, Fujise, Sato, Goto, Yamaguchi, Kuriyama, Kanno, Murakami, Tsuda, Morinaga, Higashio: Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. in Endocrinology 1998 (PubMed)
    Show all 4 references for ABIN2002484

More Proteins for Tumor Necrosis Factor Receptor Superfamily, Member 11b (Osteoprotegerin) (TNFRSF11B) Interaction Partners

Pig (Porcine) Tumor Necrosis Factor Receptor Superfamily, Member 11b (Osteoprotegerin) (TNFRSF11B) interaction partners

  1. Regional variation of periosteal activity at the mandibular ramus is regulated by differential expression of osteoprotegerin.

Rabbit Tumor Necrosis Factor Receptor Superfamily, Member 11b (Osteoprotegerin) (TNFRSF11B) interaction partners

  1. The OPG (show TNFSF11 Proteins) expression levels decreased while those of RANKL (show TNFSF11 Proteins) and RUNX2 (show RUNX2 Proteins) increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.

  2. Low-frequency vibration may promote the osteogenic differentiation capability of BMSC probably through regulating the OPG/RANKL (show TNFSF11 Proteins) mRNA expression.

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 11b (Osteoprotegerin) (TNFRSF11B) interaction partners

  1. OPG (show TNFSF11 Proteins) expression in chondrocyte increases bone mass in the proximal metaphysis of tibiae through negative regulation of osteoclast formation.

  2. the generation of Rag2GFP+ regulatory T cells is unaltered in Tnfrsf11b(-/-) mice

  3. identify osteoprotegerin as a HIF target gene capable of directing osteoblast-mediated osteoclastogenesis to regulate bone homeostasis

  4. Osteoprotegerin is increased in metabolic syndrome and promotes adipose tissue proinflammatory changes.

  5. Osteoprotegerin inhibits vascular calcification by regulating the procalcific effects of RANKL (show TNFSF11 Proteins) and Il6 (show IL6 Proteins) on vascular smooth muscle cells.

  6. These results indicate that OPG (show TNFSF11 Proteins) derived either from the bone marrow or from the vessel wall is sufficient to slow down lesion progression and vascular calcification independent of bone turnover.

  7. High concentrations of alendronate decrease the expressions of OPG (show TNFSF11 Proteins) and RANKL (show TNFSF11 Proteins) in cultured osteoblasts.

  8. In a xenograft model, increased osteoprotegerin expression correlated with a delay to pathologic fracture suggesting a potential role for mTOR (show FRAP1 Proteins) inhibitors in the treatment of neuroblastoma (show ARHGEF16 Proteins) bone metastases.

  9. Data indicate in TLR4 (show TLR4 Proteins)(-/-) mice, higher expression levels of IL-1beta (show IL1B Proteins) and lower expression levels of VEGF (show VEGFA Proteins), RANK, RANKL (show TNFSF11 Proteins) and OPG (show TNFSF11 Proteins) were detected at late time points (> postoperative 4 days).

  10. Coptisine inhibits RANKL (show TNFSF11 Proteins)-induced NF-kappaB (show NFKB1 Proteins) phosphorylation in osteoclast precursors and suppresses function through the regulation of RANKL (show TNFSF11 Proteins) and OPG (show TNFSF11 Proteins) gene expression in osteoblastic cells.

Tumor Necrosis Factor Receptor Superfamily, Member 11b (Osteoprotegerin) (TNFRSF11B) Protein Profile

Protein Summary

Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis (By similarity).

Gene names and symbols associated with TNFRSF11B

  • basic transcription factor 3 pseudogene 11 (BTF3P11)
  • tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B)
  • tumor necrosis factor receptor superfamily, member 11b (Tnfrsf11b)
  • tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) (Tnfrsf11b)
  • BTF3L1 protein
  • HUMBTFB protein
  • OCIF protein
  • Opg protein
  • TNFRSF11B protein
  • TR1 protein

Protein level used designations for TNFRSF11B

tumor necrosis factor receptor superfamily, member 11b , tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) , osteoprotegerin , Osteoprotegerin , tumor necrosis factor receptor superfamily member 11B , osteoclastogenesis inhibitory factor

GENE ID SPECIES
690 Homo sapiens
482025 Canis lupus familiaris
100049688 Sus scrofa
100348133 Oryctolagus cuniculus
25341 Rattus norvegicus
18383 Mus musculus
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